1998
DOI: 10.1074/jbc.273.52.34904
|View full text |Cite
|
Sign up to set email alerts
|

Myocyte Enhancer Factor 2C and Nkx2–5 Up-regulate Each Other's Expression and Initiate Cardiomyogenesis in P19 Cells

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

11
116
0

Year Published

2000
2000
2018
2018

Publication Types

Select...
9

Relationship

2
7

Authors

Journals

citations
Cited by 133 publications
(127 citation statements)
references
References 74 publications
11
116
0
Order By: Relevance
“…Overexpression of cardiac transcription factors can be used to direct differentiation of ES cells toward a cardiac lineage (Grepin et al, 1997;Skerjanc et al, 1998;David et al, 2008). This is likely due to an activation of a transcriptional regulatory network by the particular overexpressed factor.…”
Section: Discussionmentioning
confidence: 99%
“…Overexpression of cardiac transcription factors can be used to direct differentiation of ES cells toward a cardiac lineage (Grepin et al, 1997;Skerjanc et al, 1998;David et al, 2008). This is likely due to an activation of a transcriptional regulatory network by the particular overexpressed factor.…”
Section: Discussionmentioning
confidence: 99%
“…Several transcription factors having an essential role in cardiogenesis are up-regulated in DMSO-induced P19 cells. This was shown to be the case for the zinc-finger-containing GATA-4, the homeobox gene Nkx2-5, and the myocyte enhancer factor 2C (30,31,38), and the overexpression of either factor in P19 cells was sufficient to induce cardiac differentiation in the absence of DMSO (30,39,40). Little is known about the molecular mechanisms underlying the activation of these genes, but DMSO was found to increase intracellular Ca 2ϩ levels and was suspected to affect a pathway that has an extracellular component, possibly serum-borne (25,41,42).…”
Section: Discussionmentioning
confidence: 99%
“…The expression of MEF2C before the expression of the MRF family members may indicate that MEF2C initiates the expression of the MRFs in P19 cells. However, an alternative explanation is that cardiac muscle precursor cells are formed under the serum conditions used and that the expression of MEF2C is the result of early stages of cardiomyogenesis (47,86). Due to the heterogeneity of the cultures after aggregation, distinguishing between the two possibilities is difficult.…”
Section: Expression Of Factors Involved In Somite Patterningmentioning
confidence: 97%