“…[23][24][25][26][27][28] A great deal of effort has gone into exploring how these different bioactive agents influence TM tissue properties and cell biology in the context of AH outflow in both in vitro and in vivo studies. 15,16,24,[29][30][31][32][33][34][35][36] These efforts are beginning to unravel the participation of several different intracellular signaling mechanisms, including Rho GTPase, Wnt, ECM/ mechanotransduction, integrins, nitric oxide, PKC, BMPs/ SMADs, MAP kinases, and others, in regulating contractile properties of TM cells, ECM turnover, adhesive interactions, biomechanical properties, permeability, and survival of outflow pathway tissues and cells.…”