Myocilin Is Involved in NgR1/Lingo-1-Mediated Oligodendrocyte Differentiation and Myelination of the Optic Nerve

Kwon, Heung Sun; Nakaya, Naoki; Abu‐Asab, Mones; Kim, Hong Sug; Tomarev, Stanislav I.

doi:10.1523/jneurosci.4731-13.2014

Cited by 29 publications

(19 citation statements)

References 46 publications

(8 reference statements)

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“…It has been reported that OPCs also express the Nogo66 receptor (NgR) and LINGO-1 receptor Huang et al, 2012), and that the NgR/LINGO-1 complex inhibits optic nerve oligodendrocyte differentiation (Kwon et al, 2014). We performed an in vitro assay to assess the effects of Nogo66 on OPC differentiation following the methods described.…”

Section: Nogo66 Inhibits Opc Differentiationmentioning

confidence: 99%

WNK1 is involved in Nogo66 inhibition of OPC differentiation

Zhang

Wang

et al. 2015

Molecular and Cellular Neuroscience

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Section: Nogo66 Inhibits Opc Differentiationmentioning

confidence: 99%

WNK1 is involved in Nogo66 inhibition of OPC differentiation

Zhang

Wang

et al. 2015

Molecular and Cellular Neuroscience

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“…Variants located in LINGO1 (97 Kb from rs12898370) are in LD with rs12898370 (r 2 >0.2). LINGO1 encodes a functional component of the Nogo receptor signaling complex in RhoA activation responsible for inhibition of axonal regeneration by myelin-associated factors [Kwon et al, 2014]. A recent study observed altered Lingo-1 signaling in schizophrenia brain [Fernandez-Enright et al, 2014].…”

Section: Discussionmentioning

confidence: 99%

Ancestry‐specific and sex‐specific risk alleles identified in a genome‐wide gene‐by‐alcohol dependence interaction study of risky sexual behaviors

Polimanti

Zhao

Farrer

et al. 2017

American J of Med Genetics Pt B

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We previously mapped loci for the genome-wide association studies (GWAS) and genome-wide gene-by-alcohol dependence interaction (GW-GxAD) analyses of risky sexual behaviors (RSB). This study extends those findings by analyzing the ancestry- and sex-specific AD-stratified effects on RSB. We examined the concordance of findings for the AD-stratified GWAS and the GW-GxAD analysis of RSB, with concordance defined as genome-wide significance in one analysis and at least nominal significance in the second analysis. 2,173 African-American (AA) and 1,751 European-American (EA) subjects were investigated. Information regarding RSB (lifetime experiences of unprotected sex and multiple sexual partners) and DSM-IV diagnosis of lifetime AD were derived from the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). In our ancestry- and sex-specific analyses, we identified four independent genome-wide significant (GWS) loci (p<5*10−8) and one suggestive locus (p<6*10−8). In men, we observed a GWS signal in FAM162A (rs2002594, p=4.96*10−8). In women, there was a suggestive locus in PLGRKT (rs3824435, p=5.52*10−8). In AAs, there was a GWS signal in GRK5 (rs1316543, p=1.25*10−9). In AA men, we observed an intergenic GWS signal (rs12898370, p=4.49*10−8) near LINGO1. In EA men, there was a GWS signal in CCSER1 (rs62313897; p=7.93*10−10). The loci identified in this GWAS implicate molecular mechanisms related to psychiatric illness and personality features, suggesting that the interplay between AD and RSB is mediated by alleles associated with behavioral traits.

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“…The only abnormality observed was that female KO mice were less able to attend to litters than WT mice (Tobaben et al, 2002). Finally, although Myoc null mice demonstrated defects in myelination of sciatic and optic nerves (Kwon et al, 2013a, Kwon et al, 2014) and reduced cortical bone thickness and trabecular volume compared with wild-type mice (Kwon et al, 2013b), these mice did not develop glaucoma (Kim et al, 2001). Similarly, it has been reported that elderly woman homozygous for the Arg46Stop mutation in myocilin did not develop glaucoma (Lam et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Deletion of olfactomedin 2 induces changes in the AMPA receptor complex and impairs visual, olfactory, and motor functions in mice

Sultana

Nakaya

Dong

et al. 2014

Experimental Neurology

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Olfactomedin 2 (Olfm2) is a secretory glycoprotein belonging to the family of olfactomedin domain-containing proteins. A previous study has shown that a mutation in OLFM2 is associated with primary open angle glaucoma in Japanese patients. In the present study, we generated Olfm2 deficient mice by replacing the Olfm2 gene with the LacZ gene. Loss of Olfm2 resulted in no gross abnormalities. However, Olfm2 null mice showed reduced exploration, locomotion, olfactory sensitivity, abnormal motor coordination, and anxiety related behavior. The pattern of the Olfm2 gene expression was studied in the brain and eye using β-galactosidase staining. In the brain, Olfm2 was mainly expressed in the olfactory bulb, cortex, piriform cortex, olfactory trabeculae, inferior and superior colliculus. In the eye expression was detected mainly in retinal ganglion cells. In Olfm2 null mice, the amplitude of the first negative wave in the visual evoked potential test was significantly reduced as compared with wild-type littermates. Olfm2, similar to Olfm1, interacted with the GluR2 subunit of the AMPAR complexes and Olfm2 co-segregated with the AMPA receptor subunit GluR2 and other synaptic proteins in the synaptosomal membrane fraction upon biochemical fractionation of adult mice cortex and retina. Immunoprecipitation from the synaptosomal membrane fraction of Olfm2 null mouse brain cortex using the GluR2 antibody showed reduced levels of several components of the AMPAR complex in the immunoprecipitates including Olfm1, PSD95 and CNIH2. These results suggest that heterodimers of Olfm1 and Olfm2 interact with AMPAR more efficiently than Olfm2 homodimers and that Olfm2 plays a role in the organization of the AMPA receptor complexes.

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Myocilin Is Involved in NgR1/Lingo-1-Mediated Oligodendrocyte Differentiation and Myelination of the Optic Nerve

Abstract: Myocilin is a secreted glycoprotein that belongs to a family of olfactomedin domain-containing proteins. Although myocilin is detected

Cited by 29 publications

References 46 publications

WNK1 is involved in Nogo66 inhibition of OPC differentiation

WNK1 is involved in Nogo66 inhibition of OPC differentiation

Ancestry‐specific and sex‐specific risk alleles identified in a genome‐wide gene‐by‐alcohol dependence interaction study of risky sexual behaviors

Deletion of olfactomedin 2 induces changes in the AMPA receptor complex and impairs visual, olfactory, and motor functions in mice

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