Myocarditis in the pediatric population: A review

Dasgupta, Soham; Iannucci, Glen; Mao, Chad; Clabby, Martha L.; Oster, Matthew E.

doi:10.1111/chd.12835

Cited by 41 publications

(55 citation statements)

References 89 publications

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“…In the case of biomarkers, following trends may be more helpful than a single value. 21 LV systolic dysfunction was seen in only 4 of 30 patients (13%) who received an echo in our study. The reason for the low incidence of cardiac dysfunction in this study compared with previous reports is unclear.…”

Section: Discussioncontrasting

confidence: 53%

Cardiac Findings in Pediatric Patients With Multisystem Inflammatory Syndrome in Children Associated With COVID-19

Minocha¹,

Phoon²,

Verma³

et al. 2020

Clin Pediatr (Phila)

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Background The overall severity of cardiac disease secondary to acute SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) infection in children appears to be much lower when compared with adults. However, the newly described multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19) has been associated with cardiac complications. Methods We reviewed the clinical course and cardiac testing results in pediatric patients hospitalized with MIS-C at 2 large hospital systems in the New York City metropolitan area over a 3-month period. Results Of the 33 patients (median age 2.8 years) in the study cohort, 24 (73%) had at least one abnormality in cardiac testing: abnormal electrocardiogram (48%), elevated brain natriuretic peptide (43%), abnormal echocardiogram (30%), and/or elevated troponin (21%). Electrocardiogram and echocardiogram abnormalities all resolved by the 2-week outpatient follow-up cardiology visit. Conclusion While 73% of pediatric patients with MIS-C had evidence of abnormal cardiac testing on hospital admission in our study, all cardiac testing was normal by outpatient hospital discharge follow-up. Cardiac screening tests should be performed in all patients diagnosed with MIS-C given the high rate of abnormal cardiac findings in our study cohort.

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Section: Discussioncontrasting

confidence: 53%

Cardiac Findings in Pediatric Patients With Multisystem Inflammatory Syndrome in Children Associated With COVID-19

Minocha¹,

Phoon²,

Verma³

et al. 2020

Clin Pediatr (Phila)

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“…It is more common in males, and among children demonstrates a bimodal incidence pattern, with peaks at <2 years of age and in adolescence 11 . An evaluation for potential viral causes is recommended, although a cause is usually not found 12 . There have been prior reports of myocarditis following smallpox vaccination 10 .…”

Section: Discussionmentioning

confidence: 99%

Symptomatic Acute Myocarditis in 7 Adolescents After Pfizer-BioNTech COVID-19 Vaccination

et al. 2021

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This is a prepublication version of an article that has undergone peer review and been accepted for publication but is not the final version of record. This paper may be cited using the DOI and date of access. This paper may contain information that has errors in facts, figures, and statements, and will be corrected in the final published version. The journal is providing an early version of this article to expedite access to this information. The American Academy of Pediatrics, the editors, and authors are not responsible for inaccurate information and data described in this version.

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“…Myocarditis in children having previously been associated with TWI, ST-segment changes, low voltages on the ECG, arrhythmias, varying between 11% and 45%, and less commonly atrioventricular block. [24][25][26][27] In Kawasaki disease, changes in ventricular repolarization, flattened T-waves, arrhythmias, and AV node dysfunction have been described. [28][29][30][31] The study is limited by retrospective analysis in a single center.…”

Section: Discussionmentioning

confidence: 99%

Electrocardiographic Changes in Children with Multisystem Inflammation Associated with COVID-19

Regan

O’Byrne

Stewart

et al. 2021

The Journal of Pediatrics

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Objective To analyze findings and trends on serial electrocardiograms (ECGs) in multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease taken during the course of illness and at follow-up. Study designWe included all children presenting with MIS-C at a single center with 3 or more ECGs taken during the course of their illness. We measured ECG intervals (PR, QRSd, and QTc) and amplitudes (R-, S-, and T-waves) on each ECG and documented any arrhythmias and ST-segment changes.Results A majority of children (n = 42, 67%) showed ECG changes. The most common findings were low QRS amplitudes and transient T-wave inversion. ST changes were uncommon and included ST-segment elevation consistent with pericarditis in 1 child and acute coronary ischemia in 1 child. Arrhythmias were seen in 13 children (21%) but were benign with the exception of 1 child who was compromised by an atrial tachycardia requiring support with extracorporeal membrane oxygenation. No children were found to have high-grade atrioventricular block.Conclusions MIS-C is associated with electrocardiographic changes over the course of the illness, with low amplitude ECGs on presentation, followed by transient T-wave inversion, particularly in the precordial leads. There was a low prevalence of ST-segment changes and tachyarrhythmias.

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Myocarditis in the pediatric population: A review

Cited by 41 publications

References 89 publications

Cardiac Findings in Pediatric Patients With Multisystem Inflammatory Syndrome in Children Associated With COVID-19

Cardiac Findings in Pediatric Patients With Multisystem Inflammatory Syndrome in Children Associated With COVID-19

Symptomatic Acute Myocarditis in 7 Adolescents After Pfizer-BioNTech COVID-19 Vaccination

Electrocardiographic Changes in Children with Multisystem Inflammation Associated with COVID-19

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