Myocarditis in adult‐onset Still's disease despite significant immunosuppressive therapy

Kristensen, Lars Erik; Bartosik, I

doi:10.1080/03009740500499492

Cited by 10 publications

(4 citation statements)

References 6 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The main characteristics of the 20 included cases are displayed in Table 1 and Table 2 (Cases 5–24). 1 – 4 , 10 , 16 , 21 , 24 , 27 , 30 , 31 , 39 , 43 – 45 , 48 , 49 , 54 These cases were 15 men (75%) and 5 women (25%). The mean age at myocarditis onset was 29 years (range, 16–57 yr).…”

Section: Resultsmentioning

confidence: 97%

Myocarditis in Adult-Onset Still Disease

et al. 2014

View full text Add to dashboard Cite

This study highlights the clinical features, treatments, and outcomes of the rare myocarditis in adult-onset Still disease (AOSD). Among a case series of 57 patients fulfilling either Yamaguchi or Fautrel AOSD criteria and seen between 1998 and 2010, we identified 4 cases of myocarditis. From a comprehensive literature review, we collected 20 additional cases of myocarditis-complicated AOSD. The characteristics of patients with myocarditis were compared with those of AOSD patients without myocarditis.In these 24 myocarditis-complicated AOSD cases, myocarditis occurred early and was present at AOSD onset in 54% of the cases. Myocarditis was often symptomatic (96% of patients) with nonspecific electrocardiographic abnormalities (79% of patients) and a left ventricle ejection fraction ≤50% (67% of patients). Cardiac magnetic resonance imaging and endomyocardial biopsies showed features consistent with myocarditis in 4 patients and a mononuclear interstitial inflammatory infiltrate in 4 others. Steroids alone were effective in 50% of patients with myocarditis. Intravenous immunoglobulins, methotrexate, and tumor necrosis factor-α-blockers were also prescribed and often found effective. Only 1 patient died from cardiogenic shock. Patients with myocarditis-complicated AOSD were younger and more frequently male than patients with AOSD alone. Pericarditis was more frequent in the myocarditis group; white blood cell count, polymorphonuclear cell count, and serum ferritin levels were also higher.Myocarditis is a potentially life-threatening complication of AOSD but responds positively to steroids and other immunomodulatory drugs. Its prognosis remains good (only 1 death occurred), but the condition requires close monitoring of heart function.

show abstract

Section: Resultsmentioning

confidence: 97%

Myocarditis in Adult-Onset Still Disease

et al. 2014

View full text Add to dashboard Cite

show abstract

“…[4] Myocarditis is a known complication in AOSD and may result in cardiac failure or arrhythmia. It is therefore imperative to screen and investigate patients for cardiac involvement, particularly those presenting with chest pain, tachycardia, or mild ST elevations on ECG.…”

Section: Discussionmentioning

confidence: 99%

A case of adult-onset Still′s disease presenting with urticated plaques and acute myopericarditis

2013

View full text Add to dashboard Cite

Adult onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown etiology characterized by spiking fever, evanescent skin rash, arthralgia or arthritis, involvement of various organs, and predominantly neutrophilic leucocytosis. AOSD, although uncommon, has a characteristic constellation of clinical and laboratory features and should be considered in the differential diagnosis of pyrexia of unknown origin associated with a rash and arthralgia. The diagnosis is one of clinical suspicion and it is essential that infections, malignancy, and other rheumatic diseases are excluded. We report a case which illustrates the typical features of AOSD that were treated with steroids and azathioprine.

show abstract

“…Cardiac involvement initially needs high-dose corticotherapy, but intravenous bolus of corticoids or initial association with immunosuppressive drugs is not absolutely necessary. Only one of the reviewed patients was treated by NSAIDs,15 two others presented myocarditis under immunosuppressive treatment 7 8 even if other causes were discussed 7…”

Section: Discussionmentioning

confidence: 99%

“…It may be present as a severe polysystemic disease 4–8 with a very heterogeneous clinical presentation. As there is no specific marker, 6 7 9 the diagnosis is based on the Yamagushi criteria,10 reviewed by Fautrel et al ,11 who added hyperferritinaemia as a major criteria (table 1). …”

Section: Introductionmentioning

confidence: 99%

Adult-onset Still's disease revealed by perimyocarditis and a concomitant reactivation of an EBV infection

et al. 2012

View full text Add to dashboard Cite

SummaryWe describe a 17-year-old patient presenting perimyocarditis as the initial manifestation of the adult-onset Still's disease. Corticotherapy was rapidly successful but induced major acute hepatitis in relation with Epstein-Barr virus reactivation. After 1 year, even if the global outcome is favourable, a slightly lowered ejection fraction still persists. Former case reports and differential diagnosis with reactive haemophagocytic syndrome would be discussed. BACKGROUND

show abstract

Myocarditis in adult‐onset Still's disease despite significant immunosuppressive therapy

Cited by 10 publications

References 6 publications

Myocarditis in Adult-Onset Still Disease

Myocarditis in Adult-Onset Still Disease

A case of adult-onset Still′s disease presenting with urticated plaques and acute myopericarditis

Adult-onset Still's disease revealed by perimyocarditis and a concomitant reactivation of an EBV infection

Contact Info

Product

Resources

About