Myocardin reverses insulin resistance and ameliorates cardiomyopathy by increasing IRS-1 expression in a murine model of lipodystrophy caused by adipose deficiency of vacuolar H+-ATPase V0d1 subunit
Wenlin Yuan,
Hui Lin,
Yuan Sun
et al.
Abstract:Aim:
Adipose tissue (AT) dysfunction that occurs in both obesity and lipodystrophy is associated with the development of cardiomyopathy. However, it is unclear how dysfunctional AT induces cardiomyopathy due to limited animal models available. We have identified vacuolar H
+
-ATPase subunit V
o
d1, encoded by
Atp6v0d1
, as a master regulator of adipogenesis, and adipose-specific deletion of
Atp6v0d1
(
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