Myocardial viability assessment in 18FDG PET/CT study (18FDG PET myocardial viability assessment)

Kobylecka, Małgorzata; Mączewska, Joanna; Fronczewska-Wieniawska, Katarzyna; Mazurek, Tomasz; Płazińska, Maria Teresa; Królicki, Leszek

doi:10.5603/nmr.2012.0010

Cited by 17 publications

(11 citation statements)

References 12 publications

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“…A avaliação da viabilidade miocárdica em pacientes com doença arterial coronariana (DAC) e disfunção ventricular associada, é mandatória na definição terapêutica medicamentosa ou cirúrgica (1)(2)(3)(4) . Os traçadores comumente utilizados em nosso meio para essa avaliação são o cloreto de tálio ( 201 Tl), sestamibi-…”

Section: Introductionunclassified

“…99m Tc e o FDG-18 F, com sensibilidade e especificidade de 88% e 59%, 83% e 66%, e 93% e 63%, respectivamente (1)(2)(3)(4)(5)(6) . O 201 -Tl é ativamente transportado pela bomba de Na+/K+ ATPase e sua captação requer membrana celular íntegra, ou seja, célula miocárdica viva.…”

Section: Introductionunclassified

“…As áreas que apresentam captação de 201 -Tl, apenas na fase tardia, são as áreas de miocárdio hibernado. O sestamibi99m Tc é captado e retido nas mitocôndrias por transporte passivo, refletindo uma membrana mitocondrial intacta com função íntegra e com isso indicando viabilidade (1)(2)(3)(4)(5)(6) . A imagem metabólica com FDG-18 F baseia-se na utilização da glicose como substrato metabólico pelo miocárdio.…”

Section: Introductionunclassified

“…O miocárdio hibernado altera seu metabolismo e consome preferencialmente glicose. A captação normal ou aumentada de FDG-18 F representa a utilização de glicose pelo miocárdio hibernado (1)(2)(3)(4)(5)(6) .…”

Section: Introductionunclassified

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Valor Adicional Da Fluordesoxiglicose Marcada Com Flúor-18 Na Avaliação De Viabilidade Miocárdica

Batista¹,

Joaquim²,

Ferrari³

2017

ACS

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Con lito de interesses:Não Contribuição dos autores: CAB coleta, tabulação, delineamento do estudo e elaboração e redação do manuscrito. AIJ orientação do projeto, delineamento do estudo e elaboração do manuscrito. RJRF orientação do projeto, delineamento do estudo e elaboração do manuscrito. Contato para correspondência: Cristiano Augusto Batista E-mail: batista.cristianoaugusto@gmail. Abstract Introduction:The assessment of myocardial viability in patients presenting coronary artery disease (CAD) and associated ventricular dysfunction is an important tool for selecting patients with ischemic cardiomyopathy who may benefit from myocardial revascularization. Case review: This is a hypertensive patient in regular use of medications and in follow-up at outpatient since 2011. He had an ischemic coronary event in 2013. Cardiac catheterization showed coronary lesions in the left anterior descending artery (LAD) and right coronary artery (RCA), which were treated with stents. The patient began to develop dyspnea on moderate exertion and undergoing myocardial scintigraphy with 99m Tc-sestamibi, which showed ischemia in the left ventricular anterior wall. Echocardiography showed no ventricular dysfunction. He was treated with optimization of medications. However, in the scintigraphic control examination, the ischemic area showed up as persistent hypoperfusion. A new cardiac catheterization showed stent restenosis. For evaluation of myocardial viability, we used a scintigraphy with thallium-201 that showed no tracer uptake in the left anterior descending artery territory. As the patient remained symptomatic, a new attempt of myocardial viability research with 18 F-Fluorodeoxyglucose was performed. This showed a viable left ventricular anterior wall. Conclusion: The report confirms the greater sensitivity of Positron-emission tomography/computed tomography with 18F-Fluorodeoxyglucose in detecting a viable myocardium.Descriptors: Radionuclide Imaging; Myocardial Perfusion Imaging; Thallium; Technetium Tc 99m Sestamibi; Fluorodeoxyglucose F18.

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Valor Adicional Da Fluordesoxiglicose Marcada Com Flúor-18 Na Avaliação De Viabilidade Miocárdica

Batista¹,

Joaquim²,

Ferrari³

2017

ACS

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“…[ 18 F]FDG has been considered the gold standard for detection of the reversibility of injured myocardium with PET. 16 However, FDG uptake is influenced by confounding factors such as individual differences and myocardial inflammation of infarcted region, which often leads to false negatives and positives. 17 The use of radiolabeled necrosis-avid probes may provide depiction of infarcted myocardium to guide clinical decision-making.…”

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Novel ¹⁸F-Labeled 1-Hydroxyanthraquinone Derivatives for Necrotic Myocardium Imaging

Jin

Zhang

et al. 2017

ACS Med. Chem. Lett.

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ABSTRACT:Rapid detection and precise evaluation of myocardial viability is necessary to aid in clinical decision making whether to recommend revascularization for patients with myocardial infarction (MI). Three novel 18 F-labeled 1-hydroxyanthraquinone derivatives were synthesized, characterized, and evaluated as potential necrosis avid imaging agents for assessment of myocardial viability. Among these tracers, [ 18 F]FA3OP emerged as the most promising compound with best stability and highest targetability. Clear PET images of [ 18 F]FA3OP were obtained in rat model of myocardial infarction and reperfusion at 1 h after injection. In addition, the possible mechanisms of [ 18 F]FA3OP for necrotic myocardium were discussed. The results showed [ 19 F]FA3OP may bind DNA to achieve targetability to necrotic myocardium by intercalation. In summary, [ 18 F]FA3OP was a more promising "hot spot imaging" tracer for rapid visualization of necrotic myocardium.

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Myocardial viability assessment and utility in contemporary management of ischemic cardiomyopathy

Katikireddy

Samim

2022

Clinical Cardiology

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Background: In clinical practice, we encounter ischemic cardiomyopathy (ICM) with underlying viable, dysfunctional myocardium on a regular basis. Evidence from the Surgical Treatment for Ischemic Heart failure (STICH) and its Extension Study is supportive of improved outcomes with coronary revascularization, irrespective of myocardial viable status. However, Dobutamine stress echocardiography (DSE) and single-photon emission computed tomography (SPECT), used in STICH to assess myocardial viability may fail to distinguish hibernating myocardium from scar due to suboptimal image resolution and poor tissue characterization.Hypothesis: Cardiac magnetic resonance (CMR) and positron emission tomography (PET) can precisely quantify myocardial scar and identify metabolically active, viable myocardium respectively. Unlike DSE and SPECT, CMR and PET allow examining myocardial status as a contiguous spectrum from viable to partially viable myocardium with varying degrees of subendocardial scar and nonviable myocardium with predominantly transmural scar, the therapeutic and prognostic determinants of ICM.Methods: Under the guidance of CMR and PET imaging, myocardium can be distinguished viable from partially viable with subendocardial scar and predominantly transmural scar. In ICM, optimal medical therapy and coronary revascularization of viable/partially viable myocardium but not transmural scar may improve outcomes in patients with acceptable procedural risk.Results: Coronary revascularization of partially viable and viable myocardial territory may improve clinical outcomes by preventing future ischemic, infarct events and further worsening of left ventricular remodeling and function.Conclusions: When deciding if coronary revascularization is appropriate in a patient with ICM, it is essential to take a patient-tailored, comprehensive approach incorporating myocardial viability, ischemia, and scar data with others such as procedural risk, and patient's comorbidities.

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Myocardial viability assessment in 18FDG PET/CT study (18FDG PET myocardial viability assessment)

Cited by 17 publications

References 12 publications

Valor Adicional Da Fluordesoxiglicose Marcada Com Flúor-18 Na Avaliação De Viabilidade Miocárdica

Valor Adicional Da Fluordesoxiglicose Marcada Com Flúor-18 Na Avaliação De Viabilidade Miocárdica

Novel ¹⁸F-Labeled 1-Hydroxyanthraquinone Derivatives for Necrotic Myocardium Imaging

Myocardial viability assessment and utility in contemporary management of ischemic cardiomyopathy

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Myocardial viability assessment in 18FDG PET/CT study (18FDG PET myocardial viability assessment)

Cited by 17 publications

References 12 publications

Valor Adicional Da Fluordesoxiglicose Marcada Com Flúor-18 Na Avaliação De Viabilidade Miocárdica

Valor Adicional Da Fluordesoxiglicose Marcada Com Flúor-18 Na Avaliação De Viabilidade Miocárdica

Novel 18F-Labeled 1-Hydroxyanthraquinone Derivatives for Necrotic Myocardium Imaging

Myocardial viability assessment and utility in contemporary management of ischemic cardiomyopathy

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Novel ¹⁸F-Labeled 1-Hydroxyanthraquinone Derivatives for Necrotic Myocardium Imaging