Myocardial Texture in Hypertrophic Cardiomyopathy

Losi, Maria Angela; Betocchi, Sandro; Chinali, Marcello; Barbati, G.; D'Alessandro, G.; Cacace, Alessandra; Lombardi, Raffaella; Contaldi, Carla; Simone, Giovanni de; Chiariello, Massimo

doi:10.1016/j.echo.2007.03.023

Cited by 15 publications

(8 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the autopsy study by Shirani et al 28 on HCM patients who died suddenly, the calculated volume fraction of interstitial collagen was 8 times greater than in control subjects. Furthermore, studies of one-layer VS analysis on patients with HCM showed that the septal IB value was significantly correlated with abnormal electrical properties including ventricular late potentials and ventricular tachycardia 19 , or with the LV stiffness as assessed by Doppler echocardiography, 29 which are possibly related to myocardial fibrosis and have been reported to be predictive of cardiac death or hospitalization due to heart failure in HCM. 2,3,30,31 Myocardial fibrosis predominating in the LV mid-wall layer, ischaemic not necessarily because of coronary stenosis but rather secondary to myocardial disarray, may be a common factor leading to the unfavourable prognosis in the present and previous study.…”

Section: Discussionmentioning

confidence: 99%

Three-layer ultrasonic tissue characterization of the ventricular septum is predictive of prognosis in patients with non-obstructive hypertrophic cardiomyopathy

Kawasaki

Yamano

Kuribayashi³

et al. 2010

European Journal of Echocardiography

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Three-layer ultrasonic tissue characterization of the ventricular septum is predictive of prognosis in patients with non-obstructive hypertrophic cardiomyopathy

Kawasaki

Yamano

Kuribayashi³

et al. 2010

European Journal of Echocardiography

View full text Add to dashboard Cite

show abstract

“…Lombardi et al [58] demonstrated that as the difference in duration worsens myocardial collagen synthesis prevails over degradation; moreover, an echocardiography index of myocardial fibrosis, i.e. diastolic back scatter, increases [59], suggesting a strong interplay between diastolic function and myocardial fibrosis.…”

Section: Echocardiography and Diagnosismentioning

confidence: 99%

Echocardiography in patients with hypertrophic cardiomyopathy: usefulness of old and new techniques in the diagnosis and pathophysiological assessment

Losi

Nistri²,

Galderisi

et al. 2010

Cardiovasc Ultrasound

Self Cite

View full text Add to dashboard Cite

Hypertrophic cardiomyopathy (HCM) is one of the most common inherited cardiomyopathy. The identification of patients with HCM is sometimes still a challenge. Moreover, the pathophysiology of the disease is complex because of left ventricular hyper-contractile state, diastolic dysfunction, ischemia and obstruction which can be coexistent in the same patient. In this review, we discuss the current and emerging echocardiographic methodology that can help physicians in the correct diagnostic and pathophysiological assessment of patients with HCM.

show abstract

“…This form of tissue characterization analysis has been employed to characterize a number of cardiac pathologies including ischemia (Barzilai et al 1984), myocardial infarction (Hancock et al 2002; Iwakura et al 2003; Ohara et al 2005), cardiac hypertrophy (Losi et al 2007; Masuyama et al 1989), and changes in myocardial size, structure, and function (Di Bello et al 1998; Giglio et al 2003; Hu et al 2003; Komuro et al 2005; Madaras et al 1983; Micari et al 2006; Naito et al 1996). One such study from our laboratory examined differences in magnitude and normalized time delay of cyclic variation of backscatter among type 1 diabetic patients with systemic complications and normal controls (Perez et al 1992).…”

Section: Introductionmentioning

confidence: 99%

Quantitative Analysis of the Magnitude and Time Delay of Cyclic Variation of Myocardial Backscatter from Asymptomatic Type 2 Diabetes Mellitus Subjects

Gibson

Schaffer

Peterson

et al. 2009

Ultrasound in Medicine & Biology

View full text Add to dashboard Cite

Early detection of diabetic patients at high risk for developing diabetic cardiomyopathy may permit effective intervention. The goal of this work is to determine whether measurements of the magnitude and time delay of cyclic variation of myocardial backscatter, individually and in combination, can be used to discriminate between subgroups of individuals including normal controls and asymptomatic type 2 diabetes subjects. Two-dimensional parasternal long-axis echocardiographic images of 104 type 2 diabetic patients and 44 normal volunteers were acquired. Cyclic variation data were produced by measuring the mean myocardial backscatter level within a region-of-interest in the posterior wall, and characterized in terms of the magnitude and normalized time delay. The cyclic variation parameters were analyzed using Bayes classification and a nonparametric estimate of the area under the receiver operating characteristic (ROC) curve to illustrate the relative effectiveness of using one or two features to segregate subgroups of individuals. The subjects were grouped based on glycated hemoglobin (HbA1c), the homeostasis model assessment for insulin resistance (HOMA-IR), and the ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C). Analyses comparing the cyclic variation measurements of subjects in the highest and lowest quartiles of HbA1c, HOMA-IR, and TG/HDL-C showed substantial differences in the mean magnitude and normalized time delay of cyclic variation. Results show that analyses of the cyclic variation of backscatter in young asymptomatic type 2 diabetics may be an early indicator for the development of diabetic cardiomyopathy.

show abstract

Myocardial Texture in Hypertrophic Cardiomyopathy

Cited by 15 publications

References 34 publications

Three-layer ultrasonic tissue characterization of the ventricular septum is predictive of prognosis in patients with non-obstructive hypertrophic cardiomyopathy

Three-layer ultrasonic tissue characterization of the ventricular septum is predictive of prognosis in patients with non-obstructive hypertrophic cardiomyopathy

Echocardiography in patients with hypertrophic cardiomyopathy: usefulness of old and new techniques in the diagnosis and pathophysiological assessment

Quantitative Analysis of the Magnitude and Time Delay of Cyclic Variation of Myocardial Backscatter from Asymptomatic Type 2 Diabetes Mellitus Subjects

Contact Info

Product

Resources

About