Myocardial T1 mapping with magnetic resonance imaging – a useful tool to understand the diseased heart

Gaspar, Andreia S.; Maltes, S; Marques, Hugo; Nunes, Rita G.; Ferreira, António Miguel

doi:10.1016/j.repc.2021.04.005

Cited by 5 publications

(4 citation statements)

References 64 publications

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“…In contrast, T1 is decreased in the presence of iron overload (haemorrhagic infarction, hemochromatosis) or for fat infiltration/metaplasia (arrhythmogenic cardiomyopathy, metaplasia of old scars) [ 31 ]. The lysosomal sphingolipids deposit of FD has low T1 values, similarly to fat [ 32 ]. Among the cause of LV hypertrophy, FD is the unique condition associated with a short myocardial T1 ( Figure 1 ).…”

Section: T1 and T2 Mapping In Fabry Diseasementioning

confidence: 99%

Cardiac Magnetic Resonance in Fabry Disease: Morphological, Functional, and Tissue Features

et al. 2022

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Fabry disease (FD) is an X-linked inheritable storage disease caused by a deficiency of alpha-galactosidase causing lysosomal overload of sphingolipids. FD cardiomyopathy is characterized by left ventricular (LV) hypertrophy and should be considered in differential diagnosis with all the other causes of LV hypertrophy. An early diagnosis of FD is very important because the enzyme replacement therapy (ERT) may change the fate of patients by blocking both cardiac and systemic involvement and improving prognosis. Diagnosis may be relatively easy in young patients with the typical signs and symptoms of FD, but in male patients with late onset of disease and in females, diagnosis may be very challenging. Morphological and functional aspects are not specific to FD, which cannot be diagnosed or excluded by echocardiography. Cardiac magnetic resonance (CMR) with tissue characterization capability is an accurate technique for the differential diagnosis of LV hypertrophy. The finding of decreased myocardial T1 value in LV hypertrophy is specific to FD. Late gadolinium enhancement (LGE) is found in the late stage of the disease, but it is useful to predict the cardiac response to ERT and to stratify the prognosis.

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Section: T1 and T2 Mapping In Fabry Diseasementioning

confidence: 99%

Cardiac Magnetic Resonance in Fabry Disease: Morphological, Functional, and Tissue Features

et al. 2022

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“…Myocardial T1 is increased for oedema, for fibrosis/scar (collagen matrix of replacement scar increases the interstitial space and water content), and for amyloidotic protein deposit. On contrast, T1 is decreased in presence of iron overload (haemorrhagic infarction, hemochromatosis) or for fat infiltration\metaplasia (arrhythmogenic cardiomyopathy, metaplasia of old scar) (29). Lysosomal sphingolipids deposit of FD has low T1 values, similarly to fat (20).…”

Section: T1 and T2 Mapping In Fabry Diseasementioning

confidence: 99%

Cardiac Magnetic Resonance in Fabry Disease: Morphological, Functional and Tissue Features

Aquaro¹,

gori²,

Faggioni³

et al. 2022

Preprint

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Fabry disease (FD) is a X-linked inheritable storage disease caused by deficiency of al-pha-galactosidase causing lysosomal overload of sphingolipids. FD cardiomyopathy is character-ized by left ventricular (LV) hypertrophy and should be considered in differential diagnosis with all the other causes of LV hypertrophy. An early diagnosis of FD is very important because the enzyme replacement therapy (ERT) may change the fate of patients by blocking both cardiac and systemic involvement and improving prognosis. Diagnosis may be relatively easy in young patients with the typical signs ans symptoms of FD, but in male patients with late onset of disease and in females, diagnosis may be very challenging. Morphological and functional aspects are not specific for FD, which cannot be diagnosed or excluded by echocardiography. Cardiac magnetic resonance (CMR) with tissue characterization capability, is the preferred technique for the differential diagnosis of LV hypertrophy. The finding of decreased myocardial T1 value in LV hypertrophy is very specific for FD. Late gadolinium enhancement (LGE) is found in late stage of disease but it is useful to predict the cardiac response to ERT and to stratify the prognosis.

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“…9 In this work, we developed an Open-source prototype of myocardial T1 mapping (Open-MOLLI) using Pulseq 10,11 to implement an inversion recovery T1 mapping sequence based on the MOLLI inversion/triggering scheme for fast prototyping. Open-MOLLI 12,13 can be used as a base on top of which other sequence improvements can be performed, namely, this was already demonstrated by adding simultaneous multislice methodology 14 and changing the trajectory to radial. 15 Open-MOLLI was compared with the vendor-implemented MOLLI method, in a phantom and in vivo, regarding their accuracy and repeatability.…”

Section: Introductionmentioning

confidence: 99%

Repeatability of Open‐MOLLI: An open‐source inversion recovery myocardial T1 mapping sequence for fast prototyping

Gaspar,

Silva,

Ferreira

et al. 2024

Magnetic Resonance in Med

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PurposeTo develop an open‐source prototype of myocardial T1 mapping (Open‐MOLLI) to improve accessibility to cardiac T1 mapping and evaluate its repeatability. With Open‐MOLLI, we aim to enable faster implementation and testing of sequence modifications and to facilitate inter‐scanner and cross‐vendor reproducibility studies.MethodsOpen‐MOLLI is an inversion‐recovery sequence using a balanced SSFP (bSSFP) readout, with inversion and triggering schemes based on the 5(3)3 MOLLI sequence, developed in Pulseq. Open‐MOLLI and MOLLI sequences were acquired in the ISMRM/NIST phantom and 21 healthy volunteers. In 18 of those subjects, Open‐MOLLI and MOLLI were repeated in the same session (test–retest).ResultsPhantom T1 values were comparable between methods, specifically for the vial with reference T1 value most similar to healthy myocardium T1 (T1vial3 = 1027 ms): T1MOLLI = 1011 ± 24 ms versus T1Open‐MOLLI = 1009 ± 20 ms. In vivo T1 estimates were similar between Open‐MOLLI and MOLLI (T1MOLLI = 1004 ± 33 ms vs. T1Open‐MOLLI = 998 ± 52 ms), with a mean difference of −17 ms (p = 0.20), despite noisier Open‐MOLLI weighted images and maps. Repeatability measures were slightly higher for Open‐MOLLI (RCMOLLI = 3.0% vs. RCOpen‐MOLLI = 4.4%).ConclusionThe open‐source sequence Open‐MOLLI can be used for T1 mapping in vivo with similar mean T1 values to the MOLLI method. Open‐MOLLI increases the accessibility to cardiac T1 mapping, providing also a base sequence to which further improvements can easily be added and tested.

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Myocardial T1 mapping with magnetic resonance imaging – a useful tool to understand the diseased heart

Cited by 5 publications

References 64 publications

Cardiac Magnetic Resonance in Fabry Disease: Morphological, Functional, and Tissue Features

Cardiac Magnetic Resonance in Fabry Disease: Morphological, Functional, and Tissue Features

Cardiac Magnetic Resonance in Fabry Disease: Morphological, Functional and Tissue Features

Repeatability of Open‐MOLLI: An open‐source inversion recovery myocardial T1 mapping sequence for fast prototyping

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