Myocardial Steatosis Is an Independent Predictor of Diastolic Dysfunction in Type 2 Diabetes Mellitus

Rijzewijk, Luuk J.; Meer, R.W. van der; Smit, Johannes W. A.; Diamant, Michaëla; Bax, Jeroen J.; Hammer, Sebastiaan; Romijn, Johannes A.; Roos, Albert de; Lamb, Hildo J.

doi:10.1016/j.jacc.2008.07.062

Cited by 493 publications

(457 citation statements)

References 32 publications

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“…A positive age-associated accumulation of TG in the myocardium of rodents, as well as in the myocardium of male human subjects has been shown previously [11,18]. Furthermore, myocardial steatosis is an independent predictor of diastolic function in humans [10,11]. Moreover, pathological conditions, such as obesity and diabetes mellitus, have been shown to be related to mTG content [10,19].…”

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confidence: 84%

“…For the last decade, it has been known that intracellular triglycerides qualify as biomarkers for chronic diseases of the human organism [9]. Myocardial steatosis (mTG content obtained by 1 H-MRS) was shown to be an independent predictor of diastolic dysfunction in type 2 diabetes mellitus by Rijzewijk et al [10]. Ex vivo as well as in vivo studies revealed that myocardial TG accumulates with increased body mass and, in addition, is relevant to cardiac structure and function [3].…”

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confidence: 99%

“…Furthermore, myocardial steatosis is an independent predictor of diastolic function in humans [10,11]. Moreover, pathological conditions, such as obesity and diabetes mellitus, have been shown to be related to mTG content [10,19]. Several possible pathways for age-associated mTG accumulation have been discussed.…”

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confidence: 99%

“…As mentioned previously, mTG content is an independent predictor of the age-related decline of diastolic function in humans [10]. Contrary to this, systolic heart function is described to be independent of mTG content [3,11].…”

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confidence: 99%

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Age Dependency of Myocardial Triglyceride Content: A 3T High-Field 1H-MR Spectroscopy Study

Petritsch

Gassenmaier

Kunz

et al. 2015

Fortschr Röntgenstr

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Purpose: The role of myocardial triglyceride (mTG) content in the aging human heart is not entirely understood. The aim of this study was to measure concentrations of mTG content from healthy volunteers and to determine the association between age, mTG content and systolic heart function. Furthermore, the technical stability of the 1H-magnetic resonance spectroscopy (1H-MRS) and the reliability of peak evaluation at 3?T were evaluated. Materials and Methods: The total study population of 47 healthy volunteers was divided into 4?age classes, according to the age of the subjects (1st cohort 20???29 years (yrs.), n?=?20; 2nd cohort 30???39 yrs., n?=?10; 3rd cohort 40???49 yrs., n?=?9; 4th cohort 50???60 yrs., n?=?8). Cardiac MRI and double triggered 1H-MRS of the myocardium were consecutively performed using a 3?T scanner. Each participant underwent spectroscopic measurements twice in the same investigation. Results: mTG content increases with age. The correlation of age and mTG is minimal (r?=?0.48; p?

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confidence: 84%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Age Dependency of Myocardial Triglyceride Content: A 3T High-Field 1H-MR Spectroscopy Study

Petritsch

Gassenmaier

Kunz

et al. 2015

Fortschr Röntgenstr

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“…Diabetes is characterised by increased cardiac FA metabolism, with increased mTAG content [156,165,170] and impaired LV function [170]. TAG increases in diabetic hearts on acute fasting accompany diastolic dysfunction [171], though prolonged fasting improves insulin sensitivity, decreases mTAG and improves cardiac function, suggesting a diversion of TAG-derived FA tooxidation [172].…”

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The role of triacylglycerol in cardiac energy provision

Evans

Hui‐Kang

2016

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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Triacylglycerols (TAG) constitute the main energy storage resource in mammals, by virtue of their high energy density. This in turn is a function of their highly reduced state and hydrophobicity.Limited water solubility, however, imposes specific requirements for delivery and uptake mechanisms on TAG-utilising tissues, including the heart, as well as intracellular disposition. TAGs constitute potentially the major energy supply for working myocardium, both through bloodborne provision and as intracellular TAG within lipid droplets, but also provide the heart with fatty acids (FA) which the myocardium cannot itself synthesise but are required for glycerolipid derivatives with (non-energetic) functions, including membrane phospholipids and lipid signalling molecules. Furthermore they serve to buffer potentially toxic amphipathic fatty acid derivatives.Intracellular handling and disposition of TAGs and their FA and glycerolipid derivatives similarly requires dedicated mechanisms in view of their hydrophobic character. Dysregulation of utilisation can result in inadequate energy provision, accumulation of TAG and/or esterified species, and these may be responsible for significant cardiac dysfunction in a variety of disease states. This review will focus on the role of TAG in myocardial energy provision, by providing FAs from exogenous and endogenous TAG sources for mitochondrial oxidation and ATP production, and how this can change in disease and impact on cardiac function. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 3Key words:heart; triacylglycerol; very-low-density lipoprotein; VLDL; chylomicron; lipid droplet Highlights: Triacylglycerols are supplied to the myocardium within chylomicrons and VLDL  Heart assimilates triacylglycerol-rich lipoproteins by LPL and receptor-mediated routes  Exogenous triacylglycerol-derived fatty acids enter an intracellular lipid pool  Intracardiac triacylglycerol is an important source of fatty acids for oxidation  Dysregulation of triacylglycerol metabolism is associated with cardiac dysfunction

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Cardiac Lipids by ¹ H MRS

Szczepaniak¹,

Smith

2016

eMagRes

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Myocardial Steatosis Is an Independent Predictor of Diastolic Dysfunction in Type 2 Diabetes Mellitus

Abstract: Myocardial triglyceride content is increased in uncomplicated T2DM and is associated with impaired left ventricular diastolic function, independently of age, BMI, heart rate, visceral fat, and diastolic blood pressure.

Cited by 493 publications

References 32 publications

Age Dependency of Myocardial Triglyceride Content: A 3T High-Field 1H-MR Spectroscopy Study

Age Dependency of Myocardial Triglyceride Content: A 3T High-Field 1H-MR Spectroscopy Study

The role of triacylglycerol in cardiac energy provision

Cardiac Lipids by ¹ H MRS

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Myocardial Steatosis Is an Independent Predictor of Diastolic Dysfunction in Type 2 Diabetes Mellitus

Abstract: Myocardial triglyceride content is increased in uncomplicated T2DM and is associated with impaired left ventricular diastolic function, independently of age, BMI, heart rate, visceral fat, and diastolic blood pressure.

Cited by 493 publications

References 32 publications

Age Dependency of Myocardial Triglyceride Content: A 3T High-Field 1H-MR Spectroscopy Study

Age Dependency of Myocardial Triglyceride Content: A 3T High-Field 1H-MR Spectroscopy Study

The role of triacylglycerol in cardiac energy provision

Cardiac Lipids by 1 H MRS

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Cardiac Lipids by ¹ H MRS