Myocardial Shortening in 3 Orthogonal Directions and Its Transmural Variation in Patients With Nonobstructive Hypertrophic Cardiomyopathy

Okada, Kazunori; Yamada, Satoshi; Iwano, Hiroyuki; Nishino, Hisao; Nakabachi, Masahiro; Yokoyama, Shinobu; Abe, Ayumi; Ichikawa, Ayako; Kaga, Sanae; Nishida, Mutsumi; Hayashi, Taichi; Murai, Daisuke; Mikami, Taisei; Tsutsui, Hiroyuki

doi:10.1253/circj.cj-15-0646

Cited by 30 publications

(30 citation statements)

References 34 publications

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“…One hypothesis is that this could be partially a compensatory mechanism during LA contractile function. In the presence of more severe hypertrophy, endocardial CS tends to increase as does LVEF, reflecting decreased cavity size, while epicardial CS may reflect functional impairment from disease, worsening with phenotypes, as previously reported 33. As Geske et al4 demonstrated that LV filling pressure cannot be determined by E/e′ ratio due to the complex nature of diastolic dysfunction in HCM, LA volume or function had only a weak correlation with E/e′ ratio in this study.…”

supporting

confidence: 74%

Left atrial function and phenotypes in asymmetric hypertrophic cardiomyopathy

et al. 2017

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supporting

confidence: 74%

Left atrial function and phenotypes in asymmetric hypertrophic cardiomyopathy

et al. 2017

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“…reported that endocardial peak systolic Ecc provides a better description than global strain in the myocardial wall at the acute stage of myocardial infraction in rats33. Okada and colleagues reported that, in patients with hypertrophic cardiomyopathy, a reduced Ecc in the mid and outer layers perhaps reflects impairment of a specific layer of the myocardium2. It is possible that the transmural gradient may be a unique parameter of myocardial diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Three principal components of strain (radial, circumferential and longitudinal) can be measured, and each component used to reflect different ways of impairment in cardiac function12. Echocardiography was the primary imaging modality to detect myocardial strain due to easy availability and convenience.…”

mentioning

confidence: 99%

Distribution pattern of left-ventricular myocardial strain analyzed by a cine MRI based deformation registration algorithm in healthy Chinese volunteers

Liu

Yang

Wan

et al. 2017

Sci Rep

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The cine magnetic resonance imaging based technique feature tracking-cardiac magnetic resonance (FT-CMR) is emerging as a novel, simple and robust method to evaluate myocardial strain. We investigated the distribution characteristics of left-ventricular myocardial strain using a novel cine MRI based deformation registration algorithm (DRA) in a cohort of healthy Chinese subjects. A total of 130 healthy Chinese subjects were enrolled. Three components of orthogonal strain (radial, circumferential, longitudinal) of the left ventricle were analyzed using DRA on steady-state free precession cine sequence images. A distinct transmural circumferential strain gradient was observed in the left ventricle that showed universal increment from the epicardial to endocardial myocardial wall (epiwall: −15.4 ± 1.9%; midwall: −18.8 ± 2.0%; endowall: −22.3 ± 2.3%, P < 0.001). Longitudinal strain showed a similar trend from epicardial to endocardial layers (epiwall: −16.0 ± 2.9%; midwall: −15.6 ± 2.7%; endowall: −14.8 ± 2.4%, P < 0.001), but radial strain had a very heterogeneous distribution and variation. In the longitudinal direction from the base to the apex of the left ventricle, there was a trend of decreasing peak systolic longitudinal strain (basal: −23.3 ± 4.6%; mid: −13.7 ± 7.3%; apical: −13.2 ± 5.5%; P < 0.001). In conclusion, there are distinct distribution patterns of circumferential and longitudinal strain within the left ventricle in healthy Chinese subjects. These distribution patterns of strain may provide unique profiles for further study in different types of myocardial disease.

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“…In another study in which 41 patients with HCM were compared to 27 control subjects, not only peak GLS of all layers was reduced, but also peak GCS of the mid and outer layers were also decreased, presumably reflecting impaired myocardial function. In this other study, peak GCS of the inner layer was preserved, being associated with maintenance of chamber function [80]. Therefore, peak GLS has been proposed as a promising predictor of adverse cardiovascular outcomes which may provide additional benefit over conventional variables for risk stratification in HCM patients [81].…”

Section: Clinical Applicationsmentioning

confidence: 99%

Strain Imaging Echocardiography: What Imaging Cardiologists Should Know

López‐Candales

Hernández-Suárez

2017

CCR

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Despite recent advances in clinical imaging, echocardiography remains as the most accessi-ble and reliable noninvasive. Since knowledge of left ventricular systolic function remains so critically important in determining prognosis; every effort should be made to prevent subjective estimations. The advent of strain imaging echocardiography now offers a readily available and portable imaging tool that not only offers an objective characterization of myocardial dynamics; but also allows for early detection of subclinical left ventricular dysfunction. This review outlines the basic concepts of strain imaging to better understand the mechanism of myocardial function as well their applicability in the least common cardiac diagnosis among current clinical practice.

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Myocardial Shortening in 3 Orthogonal Directions and Its Transmural Variation in Patients With Nonobstructive Hypertrophic Cardiomyopathy

Cited by 30 publications

References 34 publications

Left atrial function and phenotypes in asymmetric hypertrophic cardiomyopathy

Left atrial function and phenotypes in asymmetric hypertrophic cardiomyopathy

Distribution pattern of left-ventricular myocardial strain analyzed by a cine MRI based deformation registration algorithm in healthy Chinese volunteers

Strain Imaging Echocardiography: What Imaging Cardiologists Should Know

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