Myocardial Sarcoidosis Presenting as Acute Mitral Insufficiency

Zoneraich, Samuel; Gupta, Meena; Mehta, Jayesh; Zoneraich, Olga; Wessely, Z

doi:10.1378/chest.66.4.452

Cited by 27 publications

(8 citation statements)

References 28 publications

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“…1,11,12 LV aneurysms have been cited in 8 to 10% of patients with myocardial sarcoidosis. 1,2,37 Severe involvement of cardiac valves is uncommon (< 3%), 1,2,11,12,38 but valvular dysfunction may result from localized involvement of the papillary muscles. 3,11 Usually, the degree of papillary muscle dysfunction is mild, but occasionally, the granulomatous infiltration is so severe that mitral valve replacement is required.…”

Section: Pathology and Sites Of Involvementmentioning

confidence: 99%

“…3,11 Usually, the degree of papillary muscle dysfunction is mild, but occasionally, the granulomatous infiltration is so severe that mitral valve replacement is required. 38,39 Less commonly, the tricuspid, aortic, or pulmonary valves are involved. 3 Finally, infiltration of the pericardium may lead to pericardial effusion and, more rarely, pericarditis.…”

Section: Pathology and Sites Of Involvementmentioning

confidence: 99%

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Cardiac Involvement in Sarcoidosis

Deng¹,

Baughman²,

Lynch³

2002

Seminars in Respiratory and Critical Care Medicine

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Cardiac sarcoidosis is a challenging diagnostic entity. Manifestations range from an incidentally discovered, benign condition to fatal cardiomyopathy and arrhythmias. In this review, we discuss the salient clinical features, diagnostic evaluation, treatment, and prognosis of cardiac sarcoidosis. A definitive histologic diagnosis of myocardial sarcoidosis is difficult, and treatment may be necessary in some patients with suspected cardiac involvement even in the absence of histologic confirmation. Optimal strategies to diagnose cardiac involvement have not been clarified. Thallium (201) radionuclide scintigraphy has been most extensively studied; 2-D echocardiography is less sensitive, but may have a complementary role. Additional radionuclide techniques (e.g., gallium (67) or technetium (99) ) may have a role in complex cases. Given the life-threatening nature of cardiac involvement, prompt and aggressive treatment with corticosteroids or immunosuppressive agents, or both, is warranted. Long-term, possibly lifelong, therapy may be required. Serious, recurrent tachyarrhythmias may require implantation of an automatic cardioverter-defibrillator. Recognizing cardiac sarcoidosis and selecting a sensible management strategy remain the major obstacles facing clinicians.

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Section: Pathology and Sites Of Involvementmentioning

confidence: 99%

Section: Pathology and Sites Of Involvementmentioning

confidence: 99%

Cardiac Involvement in Sarcoidosis

Deng¹,

Baughman²,

Lynch³

2002

Seminars in Respiratory and Critical Care Medicine

View full text Add to dashboard Cite

show abstract

“…Severe involvement of cardiac valves is uncommon (< 3%), 2,18,19,30,59 but valvular dysfunction may result from sarcoid involvement of the papillary muscles. 18,47,60 The degree of papillary muscle dysfunction is usually mild, but severe granulomatous infiltration mandating mitral valve replacement has been described.…”

Section: Cardiac Valvular Involvementmentioning

confidence: 99%

“…18,47,60 The degree of papillary muscle dysfunction is usually mild, but severe granulomatous infiltration mandating mitral valve replacement has been described. 59,61 Less commonly, the tricuspid, aortic, or pulmonary valves are involved. 18…”

Section: Cardiac Valvular Involvementmentioning

confidence: 99%