Myocardial redox state during coronary artery bypass grafting assessed with microdialysis

Abstract

Using the microdialysis technique it was possible to analyze myocardial metabolic changes during CABG. The course of myocardial LPR as a sensitive indicator of the myocardial redox state showed profound changes during and after CPB. We propose the microdialysis technique as an additional monitoring tool in CABG.

Peripheral tissue metabolism during off-pump versus on-pump coronary artery bypass graft surgery: the microdialysis study☆

“…The time course in the on-pump group is comparable to our previously reported results [6], and with the observation of the increased muscle lactate of Solligård et al [7]. In the study of Bahlmann et al [8] and also Heringlake et al [9] plasma and interstitial levels of lactate were determined during CPB, and they noticed non-increased levels of plasma lactate compared to the increased myocardial values. These findings give evidence that microdialysis data reflect local tissue metabolism and not systemic changes in metabolite plasma concentrations.…”

“…Recently, Kennergren et al [19], as well as Mantovani et al [20] investigated the troponin-T and aspartate aminotransferase levels in the myocardial interstitium of the left ventricle during cardiac surgery. Many studies deal with the investigation of the myocardial tissue during cardiac surgery and the influence of the cardiopulmonary bypass and cardioplegia on the metabolism [8,21]. In addition, other authors in their experiments on animals published results of the myocardial energy metabolism related to the myocardial ischemia, cardioplegia and cardiac muscle metabolism [4,10,15,22].…”

Myocardial metabolism assessed by microdialysis: A prospective randomized study in on- and off-pump coronary bypass surgery

“…This phenomenon has no accepted explanation but has been observed and described by other authors [19][20][21]. The interstitial pyruvate course in the off-pump group resembled that of the non-ischemic area in our animal study, while the onpump group was similar to the ischemic area of that setting [10], suggesting that off-pump technique preserved a more physiological metabolism.…”

Myocardial ischemia-reperfusion and cardioprotection: a study with microdialysis in a porcine model

“…Unfortunately, a direct access to the heart is needed. In cardiac surgery this is available and the microdialysis technique has been proven feasible (Habicht 1998), used during the surgical procedure (Bahlmann 2004), and extended into the postoperative period (Kennergren 2003), for the monitoring of myocardial ischemic changes. The early detection of deranged myocardial metabolism before the manifestation of irreversible changes may be of benefit to guide therapy.…”