Myocardial Radiomics Texture Features Associated with Increased Coronary Calcium Score—First Results of a Photon-Counting CT

Ayx, Isabelle; Tharmaseelan, Hishan; Hertel, Alexander; Nörenberg, Dominik; Overhoff, Daniel; Rotkopf, Lukas T.; Riffel, Philipp; Schoenberg, Stefan O.; Froelich, Matthias F.

doi:10.3390/diagnostics12071663

Cited by 17 publications

(17 citation statements)

References 39 publications

(40 reference statements)

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“…For example, it has been investigated whether PCD-CT might not allow the detection of textural changes in periaortic adipose tissue in relation to the presence of local aortic calcification because of its better spatial resolution and signal-to-noise ratio, and thus possibly provide a biomarker for the development of atherosclerosis 88 . The stability of radiomics features in abdominal VMIs 89 and in the myocardium 90 has been investigated, and it could be shown that some texture alterations of the left ventricular myocardium might be associated with the severity of coronary artery calcification estimated by the Agatston score 91 . We are here only at the beginning of a development whose real potential will become apparent in further studies.…”

Section: Discussionmentioning

confidence: 99%

“… 88 The stability of radiomics features in abdominal VMIs 89 and in the myocardium 90 has been investigated, and it could be shown that some texture alterations of the left ventricular myocardium might be associated with the severity of coronary artery calcification estimated by the Agatston score. 91 We are here only at the beginning of a development whose real potential will become apparent in further studies.…”

Section: Discussionmentioning

confidence: 99%

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Technical Basics and Clinical Benefits of Photon-Counting CT

Flohr

Schmidt

2023

Invest Radiol

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Novel photon-counting detector CT (PCD-CT) has the potential to address the limitations of previous CT systems, such as insufficient spatial resolution, limited accuracy in detecting small low-contrast structures, or missing routine availability of spectral information. In this review article, we explain the basic principles and potential clinical benefits of PCD-CT, with a focus on recent literature that has grown rapidly since the commercial introduction of a clinically approved PCD-CT.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Technical Basics and Clinical Benefits of Photon-Counting CT

Flohr

Schmidt

2023

Invest Radiol

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“…Also due to the novelty of the PCCT scanner and the therefore regularly necessary software updates, the voltage of the scans of the test and the validation collective differed slightly. Nevertheless, other studies in our institution have focused on the impact of the detector type (EICT vs. PCCT) on radiomics analysis of the left ventricular myocardium, outlining a possibly deeper insight into the texture by PCCT ( 30 ). The capability of PCCT of constructing monochromatic reconstructions with different keV could further improve feature stability, especially regarding second order texture features and future studies should focus on exploring the clinical applicability of this aspect ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

Pericoronary radiomics texture features associated with hypercholesterolemia on a photon-counting-CT

Kahmann,

Tharmaseelan,

Riffel

et al. 2023

Front. Cardiovasc. Med.

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IntroductionPericoronary adipose tissue (PCAT) stands in complex bidirectional interaction with the surrounding arteries and is known to be connected to many cardiovascular diseases involving vascular inflammation. PCAT texture may be influenced by other cardiovascular risk factors such as hypercholesterolemia. The recently established photon-counting CT could improve texture analysis and help detect those changes by offering higher spatial resolution and signal-to-noise ratio.MethodsIn this retrospective, single-center, IRB-approved study, PCAT of the left and right coronary artery was manually segmented and radiomic features were extracted using pyradiomics. The study population consisted of a test collective and a validation collective. The collectives were each divided into two groups defined by the presence or absence of hypercholesterolemia, taken from self-reported conditions and confirmed by medical records. Mean and standard deviation were calculated with Pearson correlation coefficient for correlation of features and visualized as boxplots and heatmaps using R statistics. Random forest feature selection was performed to identify differentiating features between the two groups. 66 patients were enrolled in this study (34 female, mean age 58 years).ResultsTwo radiomics features allowing differentiation between PCAT texture of the groups were identified (p-values between 0.013 and 0.24) and validated. Patients with hypercholesterolemia presented with a greater concentration of high-density values as indicated through analysis of specific texture features as “gldm_HighGrayLevelEmphasis” (23.95 vs. 22.99) and “glrlm_HighGrayLevelRunEmphasis” (24.21 vs. 23.31).DiscussionTexture analysis of PCAT allowed differentiation between patients with and without hypercholesterolemia offering a potential imaging biomarker for this specific cardiovascular risk factor.

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“…89 This indicates the need for further research to properly understand the reasons behind the aforementioned results. Texture features derived from the myocardium scanned with PCD-CT (NAEOTOM Alpha) may have an association with the amount of coronary artery calcification described by Ayx et al 90 Some defined myocardial radiomics-based texture features found to be different between patients with and without coronary artery calcification, resulting in more heterogeneous texture features with increasing Agatston score, which could be due to the possible myocardial fibrosis.…”

Section: Current Evidencementioning

confidence: 99%

Characterizing the Heart and the Myocardium With Photon-Counting CT

Zsarnóczay¹,

Varga-Szemes²,

Emrich³

et al. 2023

Invest Radiol

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Noninvasive cardiac imaging has rapidly evolved during the last decade owing to improvements in computed tomography (CT)–based technologies, among which we highlight the recent introduction of the first clinical photon-counting detector CT (PCD-CT) system. Multiple advantages of PCD-CT have been demonstrated, including increased spatial resolution, decreased electronic noise, and reduced radiation exposure, which may further improve diagnostics and may potentially impact existing management pathways. The benefits that can be obtained from the initial experiences with PCD-CT are promising. The implementation of this technology in cardiovascular imaging allows for the quantification of coronary calcium, myocardial extracellular volume, myocardial radiomics features, epicardial and pericoronary adipose tissue, and the qualitative assessment of coronary plaques and stents. This review aims to discuss these major applications of PCD-CT with a focus on cardiac and myocardial characterization.

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Myocardial Radiomics Texture Features Associated with Increased Coronary Calcium Score—First Results of a Photon-Counting CT

Cited by 17 publications

References 39 publications

Technical Basics and Clinical Benefits of Photon-Counting CT

Technical Basics and Clinical Benefits of Photon-Counting CT

Pericoronary radiomics texture features associated with hypercholesterolemia on a photon-counting-CT

Characterizing the Heart and the Myocardium With Photon-Counting CT

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