Myocardial, Pulmonary, and Gastric Uptake of Technetium-99m MDP in a Patient with Multiple Myeloma and Hypercalcemia

Reitz, M; Vasinrapee, Panukorn; Mishkin, Fred S.

doi:10.1097/00003072-198610000-00018

Cited by 13 publications

(8 citation statements)

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“…These diverse other conditions include primary hyperparathyroidsim, 14,22 sarcoidosis, 17 multiple myeloma, and a wide variety of nonmetabolic bone diseases, 14,21,23 Tumor lysis syndrome associated with Non-Hodgkin lymphoma, 2 hypervitaminosis D, 14,18 Milk-alkali syndrome, 13 and Cope syndrome. 19 Bush and Dahms 26 reported a patient who developed metastatic calcification attributable to hypervitaminosis A. Hypervitaminosis A is well-known to cause bone disease 29 (Table 1).…”

Section: Hypercalcemia And/or Hyperphosphatemia Associated With Othermentioning

confidence: 99%

Gastric Mucosal Calcinosis

Gorospe¹,

Fadare²

2007

Advances in Anatomic Pathology

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Generally, gastric mucosal calcinosis (GMC) is only rarely encountered in routine biopsies. GMC may be classified as dystrophic, metastatic, or idiopathic. Metastatic calcification represents the most frequently encountered subtype, and refers to the deposition of calcium salts on largely normal tissues in the setting of an abnormal serum biochemical environment (hypercalcemia, hyperphosphatemia, and/or an elevated Ca Â PO4 product). In contrast, dystrophic calcification implies calcification in inflammed, fibrotic, or otherwise altered tissue in the setting of a normal biochemical environment. The gastric mucosa, along with the kidneys and lungs, are preferential sites for metastatic calcification, a finding that has been attributed to the relative intracellular alkalinity at these sites. In addition to the wide variety of hypercalcemia and/or hyperphosphatemiacausing clinical conditions, GMC has also been associated with atrophic gastritis, hypervitaminosis A, organ transplantation, gastric neoplasia, uremia with eucalcemia/euphosphatemia, and the use of aluminum-containing antacids, citrate-containing blood products, isotretinoin, and sucralfate. Although GMC has rarely been associated with epigastric pain and/or dyspepsia, most come to clinical attention owing to their accumulation of bone-seeking radiopharmaceuticals or represent a postmortem finding. The precise significance or mechanistic basis for GMC remains to be elucidated. However, their presence in gastric biopsies should be reported, as they may serve as an indicator for generalized metastatic calcification, especially in organs where they may be fatal, such as the heart. Furthermore, some examples of systemic calcification are reversible with normalization of biochemical parameters, which highlights the need for pathologists to report this finding when encountered in a premortem gastric biopsy.

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Section: Hypercalcemia And/or Hyperphosphatemia Associated With Othermentioning

confidence: 99%

Gastric Mucosal Calcinosis

Gorospe¹,

Fadare²

2007

Advances in Anatomic Pathology

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“…Causes of metastatic calcification include hyperparathyroidism, chronic renal disease, sarcoidosis, amyloidosis, myeloma, malignant hypercalcemia of lymphomas, and solid tumors. [12345678910] The exact mechanism of these calcium depositions remains uncertain; however, most accepted mechanism is an increase in the production of ionized calcium (calcium-phosphate complex primarily). The precipitation of ionized calcium is mainly in the alkaline pH tissues: lung, kidneys, myocardium, liver, and stomach walls.…”

Section: Discussionmentioning

confidence: 99%

“…The precipitation of ionized calcium is mainly in the alkaline pH tissues: lung, kidneys, myocardium, liver, and stomach walls. [134567] Reason for hypercalcemia in malignancy is the release of parathyroid-related peptide by malignant tissues.…”

Section: Discussionmentioning

confidence: 99%

Extensive visceral calcification demonstrated on ^99mTc-MDP bone scan in patient with carcinoma penis and hypercalcemia of malignancy

Gandhi¹,

Rabadiya²

2017

Indian J Nucl Med

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Hypercalcemia is a common life-threatening complication associated with several malignancies. Parathyroid-related peptide has been shown to cause hypercalcemia in several solid tumors but rarely in penile cancer. We report a case of penile cancer with hypercalcemia causing metastatic visceral calcification in lungs, liver, and stomach detected on bone scan without significant abnormalities on CT scan.

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“…' The stomach and kidneys as well as the lungs and heart are common sites of metastatic calcification. [1][2][3][4][5][6] Renal uptake of Tc-99m HMDP in our case was considered to delineate renal calcification because of the absence of radioactivity in the urinary bladder which would indicate no production of urine. 5 Furthermore, renal visualization in the repeat scintigraphy was obvious even in the dynamic acquision.…”

Section: Discussionmentioning

confidence: 99%

“…METASTATIC CALCIFICATION is often found in cases with chronic renal disease, hemodialysis, parathyroid tumor, malignancy and hypervitaminosis D. [1][2][3][4][5][6] It is thought that accumulation of bone tracers represents the metabolic activity of calcium deposit.'. ' In this report, we show a case of gastric and renal metastatic calcifications which were delineated during a dynamic data acquisition after the tracer administration indicating a dynamism of metastatic calcification.…”

Section: Introductionmentioning

confidence: 99%

Metastatic calcification: Accumulation of a bone tracer during dynamic data acquisition

et al. 1996

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Metastatic calcification is often detected by bone scintigraphy. We recently saw metastatic calcification in the stomach and kidneys of a patient on continuous ambulatory peritoneal dialysis. Tc-99m HMDP accumulation into both organs was noted even in the first frame of dynamic data acquisition of 4 min/frame, suggesting that calcium deposits may create an aggressive process and we may obtain information on the calcium deposit rate to better understand the mechanism of metastatic calcification.

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Myocardial, Pulmonary, and Gastric Uptake of Technetium-99m MDP in a Patient with Multiple Myeloma and Hypercalcemia

Cited by 13 publications

References 0 publications

Gastric Mucosal Calcinosis

Gastric Mucosal Calcinosis

Extensive visceral calcification demonstrated on ^99mTc-MDP bone scan in patient with carcinoma penis and hypercalcemia of malignancy

Metastatic calcification: Accumulation of a bone tracer during dynamic data acquisition

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Myocardial, Pulmonary, and Gastric Uptake of Technetium-99m MDP in a Patient with Multiple Myeloma and Hypercalcemia

Cited by 13 publications

References 0 publications

Gastric Mucosal Calcinosis

Gastric Mucosal Calcinosis

Extensive visceral calcification demonstrated on 99mTc-MDP bone scan in patient with carcinoma penis and hypercalcemia of malignancy

Metastatic calcification: Accumulation of a bone tracer during dynamic data acquisition

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Extensive visceral calcification demonstrated on ^99mTc-MDP bone scan in patient with carcinoma penis and hypercalcemia of malignancy