“…Numerous studies have examined the ventricular function, stroke volume, myocardial blood flow, cellular and extracellular structural changes within the myocardium, contractile processes in isolated myocytes, levels of catecholamines, activation of the -adrenergic receptor system, and neurohormonal system in the pacing-induced CHF (6, 20, 22-24, 26, 31, 35, 36, 38, 40, 41). The increase of vascular flow resistance and the regional deficit of myocardial blood flow were also found after the LV pacing (6,16,18,24). There are no systematic studies on the structure-function remodeling of the entire coronary arterial tree in response to the increase of vascular resistance in the pacing-induced CHF.…”