Myocardial Perfusion Imaging Using OMNISCAN: A Dose Finding Study for Visual Assessment of Stress?Induced Regional Perfusion Abnormalities

Abstract

Visual assessment of myocardial perfusion using a high-flow rate contrast agent bolus injection and a TFE-EPI sequence can be best achieved with a dose of gadodiamide 0.1 mmol/kg bodyweight.

Magnetic Resonance Adenosine Perfusion Imaging in Patients After Coronary Artery Bypass Graft Surgery

“…This approach cannot be applied to patients with known CAD, as the issue of ischemia needs to be addressed. Our results (sensitivity 77%, specificity 90%) are comparable to those of published CMR data with sensitivities of 84% to 93% and specificities of 58% to 85% (1)(2)(3)(4)16). However, when compared with patients who have suspected CAD using the same imaging technique in our institution, sensitivity is reduced (21).…”

“…Adenosine stress perfusion allows the assessment of patients with suspected or known CAD (1)(2)(3)(4)(5)16) with potential advantages compared with SPECT (17). However, to the best of our knowledge, no published report exists evaluating this technique in patients with previous bypass surgery.…”

High-resolution myocardial stress perfusion at 3 T in patients with suspected coronary artery disease

“…Comparing our results at 3 T with previous results at 1.5 T based on a visual analysis, our protocol is at least as efficacious as those at 1.5 T [16][17][18][19][20]. However this We performed only a visual assessment of stress-induced myocardial perfusion defects in our study.…”

“…All slices were divided into a total number of 16 segments according to the AHA recommendations for diagnostic imaging [7]. The apical section (segment 17) was not considered in this analysis as only short-axis images were obtained. Stress scans were classified as pathologic if at least one segment had diminished and/or had delayed contrast enhancement in comparison to the resting study.…”

Cardiovascular magnetic resonance myocardial perfusion: methods and applications in patients with coronary artery disease

“…The optimal dose of contrast agent for perfusion CMR has not been determined, but a number of studies have helped identify the correct range. The best dose of gadodiamide for visual assessment of stress-induced regional perfusion abnormalities was identifi ed with 0.1mmol/kg bodyweight (as opposed to 0.05 and 0.15mmol/kg bodyweight) using a GRE-EPI (Gradient Echo-Echo Planar Imaging) sequence (17) . Superior image quality was found with an SSFP (Steady State Free Precession) sequence with both dosage regimes of 0.05mmol/kg and 0.025mmol/kg bodyweight for Gd-BOPTA, in comparison with T1-GRE or GRE-EPI sequences (18) .…”