Myocardial Perfusion Color Scintigraphy with MAA

Regional myocardial and organ blood flow after myocardial infarction: application of the microsphere principle in man.

“…Cm 100 ml/minIlO0 g) (2) Cb where Fa is the withdrawal rate of arterial blood (ml/min), Cm is the activity in each tomographic region, and Cb is the total activity in the arterial sample (counts/min). 46 Regional myocardial blood flow. The tomograms of the heart were reconstructed and decay corrected to the time of injection.…”

<title>Tutorial Nuclear Cardiography And Scintigraphy</title>

“…Since Domenec et al (30) demonstrated the feasibility of measuring myocardial flow in animals after left atrial injection of radio active microspheres, this technique has gained widespread application (31)(32)(33)(34)(35)(36). The method was extended by Ashburn et al to study the regional distribution of myocardial perfusion by direct intracoronary injection of the radiolabeled particles (31).…”

“…It is then not only possible to determine the vi ability or non-viability of the microcircula tion of each bed but also to gain an estimate of collateral flow from one capillary bed to the other. Jansen and Judkins (32,33) have used this technique in several hundred patients and are proponents of its more routine use in the assessment of patients prior to aortocoronary bypass surgery. These authors sug gest that if an adequate viable microcircula tion can be demonstrated distal to a critical stenosis, the vessel should be considered a good candidate for bypass surgery.…”

“…Ashburn et al subse quently demonstrated that it was possible to visualize myocardial regional distribution of blood flow in patients with coronary artery disease after injection of macroaggregated ser um albumin labeled with radioactive tracers in the coronary arteries (31). Jansen, Judkins and co-workers extended these studies to large numbers of patients demonstrating the safety of the technique and its usefulness in provid ing visualization of the myocardial microcirculation (32)(33). In addition to assessing the viability of the coronary microcirculation in the resting state the dual isotope coronary macroaggregate method has also been applied to the assessment of the effect of an interven tion on the coronary microcirculation.…”