Myocardial Perfusion by Coronary Computed Tomography in the Evaluation of Myocardial Ischemia: Simultaneous Stress Protocol with SPECT

Abstract

Background: Functional assessment to rule out myocardial ischemia using coronary computed tomography angiography (CCTA) is extremely important and data on the Brazilian population are still limited.Objective: To assess the diagnostic performance of myocardial perfusion by CCTA in the detection of severe obstructive coronary artery disease (CAD) compared with single-photon emission computerized tomography (SPECT). To analyze the importance of anatomical knowledge to understand the presence of myocardial perfusion defects on SPECT imaging that is not identified on computed tomography (CT) scan.Method: A total of 35 patients were evaluated by a simultaneous pharmacologic stress protocol. Fisher's exact test was used to compare proportions. The patients were grouped according to the presence or absence of significant CAD. The area under the ROC curve was used to identify the diagnostic performance of CCTA and SPECT in perfusion assessment. P < 0.05 values were considered statistically significant.Results: For detection of obstructive CAD, CT myocardial perfusion analysis yielded an area under the ROC curve of 0.84 [a 95% confidence interval (CI95%): 0.67-0.94, p < 0.001]. SPECT myocardial perfusion imaging, on the other hand, showed an AUC of 0.58 (95% CI 0.40 -0.74, p < 0.001). In this study, false-positive results with SPECT are described. Conclusion: Myocardial perfusion analysis byCTA displays satisfactory results compared to SPECT in the detection of obstructive CAD. CCTA can rule out false-positive results of SPECT.

Role of Coronary Computed Tomography Angiography and Stress Single Photon Emission Computed Tomography in Evaluation of Chest Pain in Diabetic and Non-Diabetic Patients

“…A higher incidence of positive results using SPECT (58%) than using CT (42%) which was partially in agreement with the study done by Ker et al (2019), 57.1% of the patients presented perfusion defects at myocardial scintigraphy, with 28.5% also presenting defects at CT. DM has reached epidemic proportions, creating a large population of people at increased risk for cardiac events. Singlephoton emission computed tomography myocardial perfusion imaging (SPECT MPI) provides an effective tool to accurately diagnose and risk stratify patients with diabetes, similar to patients without diabetes.…”