Myocardial Mechanics for the Early Detection of Cardiac Sarcoidosis

Early Detection of Bi-ventricular and Atrial Mechanical Dysfunction Using Two-Dimensional Speckle Tracking Echocardiography in Patients with Sarcoidosis

“…Our study also demonstrated impaired radial and circumferential strain in sarcoidosis patients. In a recent study, Aggeli et al [6] showed significantly lower LV GLS and higher twist in patients with sarcoidosis. In our study, we demonstrated that LV GLS, twist, and untwist were lower in sarcoidosis patients compared to controls, suggesting early subclinical cardiac involvement.…”

“…The underlying mechanism responsible for decreased strain parameters in patients with sarcoidosis is controversial. Sarcoid myocardial infiltration usually occurs initially in the midmyocardial layer of the LV wall, suggesting early impairment of LV longitudinal strain [6]. Midmyocardial circumferential fibers are responsible for radial and circumferential shortening.…”

“…Detection of myocardial involvement by two-dimensional (2D) speckle tracking echocardiography (STE) is a new technique for evaluating myocardial functions. Previously, it has been shown that 2D STE is a useful method for the detection of subclinical myocardial involvement in patients with sarcoidosis [6]. The aim of this study is to investigate the impact of sarcoidosis on bi-ventricular and atrial mechanics using 2D STE.…”

Strain Imaging

“…93,94 The data on 2D speckle strain imaging in diagnosing cardiac sarcoidosis are sparse at this time. Aggeli et al 95 found that patients with biopsy-proven sarcoidosis presented lower values of 2D speckle GLS (14.41 ± 3.01% vs 22.93 ± 2.28%, P < 0.05), although twist (10.2 ± 3.9° vs 8.5 ± 1.3°, P < 0.05) appeared to be increased when compared with the control group. Figure 5 is a bull's eye graph depicting strain in a normal person and in a patient with sarcoidosis.…”

“…Figure 5 is a bull's eye graph depicting strain in a normal person and in a patient with sarcoidosis. 95 On 3D speckle strain analyses in 23 cardiac sarcoidosis patients with an EF of 46 ± 10% and 16 EF-matched patients with dilated cardiomyopathy (EF 45 ± 11%), Tsuji et al 96 determined that the GRS of patients with cardiac sarcoidosis was significantly lower than that of patients with dilated cardiomyopathy. However, there was no significant difference in the values of GCS and GLS in the 2 groups.…”