Myocardial material property determination in the in vivo heart using magnetic resonance imaging

Moulton, Michael J.; Creswell, Lawrence L.; Downing, Stephen W.; Actis, Ricardo L.; Szabó, Barna; Pasque, Michael K.

doi:10.1007/bf01806218

Cited by 37 publications

(19 citation statements)

References 26 publications

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“…Based on in vitro biaxial stress-strain experiments (Nielsen et al, 1991), Hunter (1995) proposed an orthotropic ''pole-zero'' constitutive law describing the different stress-strain relationships in the fiber, sheet, and sheet-normal directions. A 3D FE model of the left ventricular (LV) myocardium that includes a description of the morphological fiber and sheet structures and uses the pole-zero constitutive law based on finite deformation theory will give more realistic deformation patterns than the model of Moulton et al (1995Moulton et al ( , 1996. However, the pole-zero constitutive law contains 18 material parameters but some are coupled via a micro-structural model (Nash and Hunter, 2000).…”

Section: Introductionmentioning

confidence: 98%

“…From human subjects it is not feasible to obtain tissue samples. Moulton et al (1995Moulton et al ( , 1996 developed an in vivo method for determining material properties by fitting a 2D FE model to strain measurements from magnetic resonance imaging (MRI) tagging. They were able to estimate the two material parameters of an isotropic, nonlinear, small deformation 2D FE model.…”

Section: Introductionmentioning

confidence: 99%

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Development of an in vivo method for determining material properties of passive myocardium

Remme

Hunter

Smiseth³

et al. 2004

Journal of Biomechanics

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Development of an in vivo method for determining material properties of passive myocardium

Remme

Hunter

Smiseth³

et al. 2004

Journal of Biomechanics

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“…The idea of using the LVP as a gating signal for MR based strain calculations is not a new one [13]. Here, we present a software based implementation of this idea.…”

Section: Discussionmentioning

confidence: 99%

Left Ventricular Pressure Gating in Ovine Cardiac Studies: A Software-Based Method

Acevedo-Bolton

Suzuki²,

Malhotra³

et al. 2013

Journal of Biomechanical Engineering

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Cardiac imaging using magnetic resonance requires a gating signal in order to compensate for motion. Human patients are routinely scanned using an electrocardiogram (ECG) as a gating signal during imaging. However, we found that in sheep the ECG is not a reliable method for gating. We developed a software based method that allowed us to use the left ventricular pressure (LVP) as a reliable gating signal. By taking the time derivative of the LVP (dP/dt), we were able to start imaging at both end-diastole for systolic phase images, and end-systole for diastolic phase images. We also used MR tissue tagging to calculate 3D strain information during diastole. Using the LVP in combination with our digital circuit provided a reliable and time efficient method for ovine cardiac imaging. Unlike the ECG signal the left ventricular pressure was a clean signal and allowed for accurate, nondelay based triggering during systole and diastole.

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“…29 Thus, several studies 11,15,16,33 have been proposed in order to determine passive and active adult heart properties. In a pioneering in vivo MRI study, Moulton et al 29 determined the diastolic material properties of the canine myocardium using a two-dimensional (2D) FE analysis, assuming that the cardiac muscle behaves as an isotropic material. Considering a more realistic stressstrain relationship, Okamoto et al 33 determined passive anisotropic myocardial material properties by using a three-dimensional (3D) FE model and in vivo MRI measurements also acquired from dogs.…”

Section: Introductionmentioning

confidence: 99%

“…37 Furthermore, several studies have supported the idea that FH growth is modulated by the amplitude of the local wall stresses generated during the cardiac cycle. 29,41,42 In this context, biomechanical models are of great help to investigate the coupling between mechanical stress and heart development. However, due to the lack of experimental data, only a few biomechanical models have attempted to simulate the behavior of the normal human FH during gestation.…”

Section: Introductionmentioning

confidence: 99%

Unraveling Changes in Myocardial Contractility During Human Fetal Growth: A Finite Element Analysis Based on In Vivo Ultrasound Measurements

et al. 2010

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Knowledge of normal fetal heart (FH) performance and development is crucial for evaluating and understanding how various congenital heart lesions may modify heart contractility during the gestational period. However, since biomechanical models of FH are still lacking, structural approaches proposed to describe the mechanical behavior of the adult human heart cannot be used to model the evolution of the FH. In this paper, a finite element model of the healthy FH wall is developed to quantify its mechanical properties during the gestational period. An idealized thick-walled ellipsoidal shape was used to model the left ventricle (LV). The diastolic LV geometry was reconstructed from in vivo ultrasound measurements performed on 24 normal FHs between 20 and 37 weeks of gestation. An anisotropic hyperelastic constitutive law describing the mechanical properties of the passive and active myocardium was used. The evolution of the mechanical properties of the normal LV myocardium during fetal growth was obtained by successfully fitting the ejection fraction predicted by the model to in vivo measurements. We found that only the active tension varies significantly during the gestational period, increasing linearly from 20 kPa (at 20 weeks) to 40 kPa (at 37 weeks of gestation). We propose a possible explanation of the increasing force-generating ability of the myocardial tissue during fetal heart development based on a combination of myocyte enlargement, differentiation, and proliferation kinetics.

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Myocardial material property determination in the in vivo heart using magnetic resonance imaging

Abstract: This parameter estimation algorithm provides the necessary framework for estimating the nonlinear, anisotropic and non-homogeneous material properties of passive myocardium in health and disease in the in vivo beating heart.

Cited by 37 publications

References 26 publications

Development of an in vivo method for determining material properties of passive myocardium

Development of an in vivo method for determining material properties of passive myocardium

Left Ventricular Pressure Gating in Ovine Cardiac Studies: A Software-Based Method

Unraveling Changes in Myocardial Contractility During Human Fetal Growth: A Finite Element Analysis Based on In Vivo Ultrasound Measurements

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