Myocardial ischemia in Kawasaki disease: Evaluation with dipyridamole stress technetium 99m tetrofosmin scintigraphy

Fukuda, Tsuyoshi; Ishibashi, Masatoshi; Yokoyama, Tatsuo; Otaki, M; Shinohara, T; Nakamura, Yoshihide; Miyake, Toshiharu; Kudoh, Takashi; Oku, Hirosuke

doi:10.1067/mnc.2002.125915

Cited by 29 publications

(12 citation statements)

References 13 publications

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“…It is well known that CAG and SPECT are consistent with coronary artery stenosis. 9,13,18 SPECT is a highly sensitive, but non-specific technique in detecting coronary artery stenosis, as patients show perfusion defects according to the degree of obstruction and lack of collateral circulation. This concordance is better in adults because of the higher homogeneity of coronary lesions due almost exclusively to arteriosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Do Kawasaki disease patients without coronary artery abnormalities need a long‐term follow‐up? A myocardial single‐photon emission computed tomography pilot study

Zanon¹,

Zucchetta²,

Varnier³

et al. 2009

J Paediatrics Child Health

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Section: Discussionmentioning

confidence: 99%

Do Kawasaki disease patients without coronary artery abnormalities need a long‐term follow‐up? A myocardial single‐photon emission computed tomography pilot study

Zanon¹,

Zucchetta²,

Varnier³

et al. 2009

J Paediatrics Child Health

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“…Fukuda et al observed among children with Kawasaki's disease that coronary artery stenoses may be visualized with dipyridamole stress technetium 99m tetrafosmin SPECT with a sensitivity of 90% and specificity of 100%. 6 However, Fu et al observed that coronary aneurysms without stenoses are more difficult to detect, with only 30% exhibiting abnormal perfusion images. 7 CCTA easily visualizes extraluminal remodeling and may provide a noninvasive alternative to angiography for evaluation of coronary artery aneurysms.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of coronary artery aneurysm and stenosis using open-source myocardial perfusion SPECT and coronary computed tomographic angiography image fusion software

Collins

Min

Lin

2010

Journal of Nuclear Cardiology

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A 49-year-old man with a past history of percutaneous coronary intervention presented with chest pain during emotional stress. His chest pain was mild, nonexertional, and spontaneously relieved without intervention. His past medical history was significant for hypertension, diabetes, dyslipidemia, smoking, and morbid obesity. Four years previously, he had undergone coronary angiography revealing obstructive coronary artery disease in the first obtuse marginal and the right posterior descending arteries as well as a coronary aneurysm in the right coronary artery, and undergone intervention with sirolimus-eluting stents in the obtuse marginal and posterior descending arteries. He was taking aspirin, clopidogrel, metoprolol succinate, and fenofibrate with intermittent adherence. He did not report any history of Kawasaki disease and had an unlimited exercise tolerance.The patient underwent 64-slice cardiac computed tomography (CCTA) for surveillance of the coronary artery aneurysm (scan parameters: GE Gemstone 64-slice CCTA scanner, 0.625 mm detector width and collimation, 0.35 s/rotation, axial scanning with prospective gating at 75% of the RR interval with no padding, 120 kV, 650 mA, SFOV 25, three-phase iodixanol protocol (60 cc contrast, 40 cc of a 50:50 contrast:saline mixture, 40 cc saline)). The estimated effective dose was 2.51 mSv. Obstructive (defined as visually estimated 70-100% intraluminal stenosis) plaques were visualized in the proximal left anterior descending artery, the proximal first diagonal branch, the mid left circumflex, and the proximal posterior descending arteries ( Figure 1A-D). There was obstructive in-stent restenosis in the proximal first obtuse marginal artery stents and the posterior descending artery ( Figure 1D, E). The proximal and mid right coronary artery segments were aneurysmal with a maximum diameter of 1.8 cm ( Figure 1E).The patient underwent regadenoson stress myocardial perfusion SPECT (MPS) with a single-isotope oneday sestamibi protocol for evaluation of the functional significance of his coronary artery disease. With peak pharmacologic stress the patient achieved a heart rate of 106 and a brachial cuff pressure of 177/116 from a baseline heart rate of 92 and blood pressure 161/111, with no symptoms or ECG changes. Perfusion imaging with 11.0 mCi (.41 GBq) for rest and 36.8 mCi (1.36 GBq) for stress demonstrated abnormal myocardial perfusion with mild intensity, reversible defects involving the basal anterior wall, moderate intensity, partially reversible defects involving the mid to distal anterior wall, and severe intensity, partially reversible defects involving the apex, as well as moderate intensity, fixed defects involving the basal inferior wall and severe intensity, partially reversible defects involving the mid to distal inferior wall ( Figure 2). Gated SPECT demonstrated a post-stress ejection fraction of 38% (EDV 211 mL) with mild to moderate hypokineses of the inferior wall and severe hypokinesis of the apex.Image registration and fusion of the CCTA and stres...

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“…Сцинтиграфия дает возможность обнаружить как ранние признаки ишемии, так и тяжелые рубцо-вые поражения. Чувствительность метода возрастает при применении физической или фармакологической нагрузки [44,45]. Высокая лучевая нагрузка ограничи-вает его применение.…”

Section: непрерывное профессиональное образованиеunclassified

Kawasaki Syndrome With Involvement of Cardiovascular System: Long-Term Consequences

Ширинская¹,

Лыскина²,

Бокерия³

et al. 2013

Vopr. sovr. pediatr.

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ВВЕДЕНИЕ Синдром Кавасаки (СК), или слизисто-кожный лим-фонодулярный синдром, представляет собой остро про-текающее системное заболевание, которое характери-зуется развитием васкулита, преимущественно артерий среднего калибра, с частым поражением коронарных (КА) и других висцеральных артерий. В настоящее время в развитых странах мира СК является основной причиной

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Myocardial ischemia in Kawasaki disease: Evaluation with dipyridamole stress technetium 99m tetrofosmin scintigraphy

Abstract: Tetrofosmin myocardial perfusion imaging can detect regional hypoperfusion in children with KD.

Cited by 29 publications

References 13 publications

Do Kawasaki disease patients without coronary artery abnormalities need a long‐term follow‐up? A myocardial single‐photon emission computed tomography pilot study

Do Kawasaki disease patients without coronary artery abnormalities need a long‐term follow‐up? A myocardial single‐photon emission computed tomography pilot study

Evaluation of coronary artery aneurysm and stenosis using open-source myocardial perfusion SPECT and coronary computed tomographic angiography image fusion software

Kawasaki Syndrome With Involvement of Cardiovascular System: Long-Term Consequences

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