Myocardial ischaemia in sickle cell anaemia: evaluation using a new scoring system

Bode‐Thomas, Fidelia; Hyacinth, Hyacinth I.; Ogunkunle, O. O.; Omotoso, Ayodele

doi:10.1179/1465328110y.0000000006

Cited by 24 publications

(28 citation statements)

References 17 publications

(24 reference statements)

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“…Myocardial ischemia and infarction have been reported to occur in SCD, but in almost all cases evaluated in the literature and in our practice at the National Institutes of Health, coronary angiography reveals normal coronary arteries (82–86). Case reports of patients presenting with acute crisis have shown ECG abnormalities (87), nuclear perfusion defects (88,89), MRI abnormalities (84) and troponin elevations (86) suggestive of acute myocardial infarction.…”

Section: Myocardial Infarctionmentioning

confidence: 89%

Cardiovascular Abnormalities in Sickle Cell Disease

Gladwin

Sachdev

2012

Journal of the American College of Cardiology

223

215

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Section: Myocardial Infarctionmentioning

confidence: 89%

Cardiovascular Abnormalities in Sickle Cell Disease

Gladwin

Sachdev

2012

Journal of the American College of Cardiology

223

215

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“…Moreover, ECG features consistent with atrio‐ventricular and ventricular repolarization abnormalities are present, such as increased P‐wave duration, PR‐interval and QTc dispersion, associated with cardiovascular autonomic dysfunction (Oguanobi et al , ). Recently, Bode‐Thomas et al () published a new scoring system based on the standard surface electrocardiogram in determining the prevalence and severity of MI in children with SCD. Their proposed MI scoring system could be a useful screening tool for early detection of significant MI during crises, facilitating early institution of intervention (Bode‐Thomas et al , ).…”

Section: Myocardial Ischaemia (Mi) Cardiac‐related Chest Pain and Sumentioning

confidence: 99%

“…Recently, Bode‐Thomas et al () published a new scoring system based on the standard surface electrocardiogram in determining the prevalence and severity of MI in children with SCD. Their proposed MI scoring system could be a useful screening tool for early detection of significant MI during crises, facilitating early institution of intervention (Bode‐Thomas et al , ).…”

Section: Myocardial Ischaemia (Mi) Cardiac‐related Chest Pain and Sumentioning

confidence: 99%

Sickle‐cell disease and the heart: review of the current literature

2012

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Summary Sickle cell disease (SCD) is an inherited chronic haemolytic anaemia whose clinical manifestations arise from the tendency of the haemoglobin to polymerize and deform red blood cells into the characteristic sickle shape due to a single nucleotide change in the β‐globin. Vascular occlusion of small and large vessels can lead to chronic damage of multiple organs including brain, lung, bone, kidney, liver, spleen, and retina. However, the extent to which SCD impacts myocardial function is not very clear. Cardiovascular manifestations include both right and left ventricular systolic and diastolic dysfunction, elevated cardiac output, cardiomegaly and myocardial ischaemia. Progressive heart damage from iron overload occurs in patients requiring routine transfusion therapy. Pulmonary hypertension resulting from intravascular haemolysis has also been recognized as a major complication that independently correlates with survival. This review summarizes all available data for the heart complications in SCD to update the physicians for their appearance, diagnostic procedures and possible management.

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“…This vasculopathy might also play a role in other chronic organ dysfunction in patients with sickle cell disease. [5][6][7][8] Carotid Intima-Media Thickness (CIMT) is a noninvasive, early marker of atherosclerosis, an increase in this measure may reflect an increase in cardiovascular risk. 9 This is an independent predictor of CVD and may be considered as a surrogate marker for the assessment of subclinical atherosclerosis, inflammation and vasculopathy in SCD individuals.…”

Section: Introductionmentioning

confidence: 99%

Carotid and femoral intima-media thickness in adults with sickle cell disease

et al. 2019

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Background: This study was conducted to evaluate Carotid Intima Media Thickness (CIMT) and Femoral Intima Media Thickness (FIMT) in adults with SCD. Methods: The present prospective cross-sectional study with control group was carried out in Department of Medicine at Acharya Vinoba Bhave rural hospital over a period of 6months from January to June 2018. A total of 100 (50 cases of SCD, 50 normal subjects) were studied. In the SCD group, 35 cases were patients regular follow up cases and 15 patients were in sickle cell crisis. CIMT of both left and right carotids were taken and the mean of the two values were recorded. The IMT was also measured in the right common femoral artery (RCFA) and left common femoral artery. Results: SCD patients in steady state had significantly decreased Hb%, increased WBC counts and platelet counts as compared to healthy controls. The mean right FIMT, left FIMT, right CIMT and left CIMT the patients with SCD with crisis were significantly higher than that of the patients without SCD (P<0.001). One way showed that there were significant differences in duration of disease in mean level of Hb%, WBC count, platelet count of the patients in the three groups (p<0.01). Conclusions: CIMT and FIMT can pick up the macrovascular involvement early and can be utilized as screening tools to predict vascular injury so that at risk individuals would be subjected to proper treatment protocols, especially hydroxyurea therapy early on.

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Myocardial ischaemia in sickle cell anaemia: evaluation using a new scoring system

Abstract: Background-Sickle cell anaemia (SCA) is associated with recurrent multi-organ ischaemia and infarction. Myocardial ischaemia (MI) and infarction are increasingly recognised as features of SCA. The prevalence and severity of MI in children with SCA is not known.

Cited by 24 publications

References 17 publications

Cardiovascular Abnormalities in Sickle Cell Disease

Cardiovascular Abnormalities in Sickle Cell Disease

Sickle‐cell disease and the heart: review of the current literature

Carotid and femoral intima-media thickness in adults with sickle cell disease

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