Myocardial ischaemia in children with sickle cell disease

Montalembert, Mariane de

doi:10.1136/adc.2003.027326

Cited by 55 publications

(40 citation statements)

References 17 publications

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“…Microcirculatory changes could result in reduction of oxygen supply to the myocardium and coronary ischemia [24]. This hypothesis is supported by myocardial perfusion scintigraphy studies which have shown a high incidence of perfusion abnormalities in patients with SCD [4, 25]. Using multidetector row computed tomography angiography, Raman et al [26 ]examined 21 adult patients with SCD.…”

Section: Discussionmentioning

confidence: 81%

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Increased QT Dispersion in Sickle Cell Disease: Effect of Pulmonary Hypertension

et al. 2007

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Background: QT dispersion has been proposed to be a predictor of adverse outcomes in a variety of cardiac disease states. The objective of this study was to examine QT dispersion in patients with sickle cell disease (SCD) and to assess the effect of pulmonary hypertension (PHT) on QT dispersion. Methods: We performed Doppler echocardiographic assessments of pulmonary artery systolic pressure in 73 (mean age 18.5 ± 8.0 years) steady-state SCD patients and 25 (mean age 19.6 ± 7.2 years) healthy subjects. Resting 12-lead electrocardiogram was recorded and QT dispersion was calculated as the difference between maximum and minimum QT intervals. Bazett’s formula was used to obtain a rate-corrected value of the QT interval (QTc). Results: Maximum QTc, minimum QTc and QTc dispersion were significantly increased in SCD patients compared to the control subjects (p < 0.0001, p < 0.05, p < 0.0001, respectively). Among SCD patients, patients with PHT had higher maximum QTc and QTc dispersion than patients without PHT (p < 0.0001). However, minimum QTc showed no significant differences between the two patient groups. Conclusion: QTc dispersion is significantly increased in SCD patients, especially those with PHT indicating regional inhomogeneity of ventricular repolarization.

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Section: Discussionmentioning

confidence: 81%

“…Postmortem examinations have revealed degenerative myocardial changes and multiple foci of degenerative abnormalities in the cardiac conduction system [3]. Myocardial ischemia, ventricular arrhythmias and sudden death due to cardiac arrest have also been reported in SCD patients [3,4,5,6]. …”

Section: Introductionmentioning

confidence: 99%

Increased QT Dispersion in Sickle Cell Disease: Effect of Pulmonary Hypertension

et al. 2007

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“…Older children with SCD tend to have more extensive ischemic defects than younger patients. 26 Haywood 27 reported that myocardial dysfunction may be related to long-term recurrent myocardial microinjuries and metabolic tissue alterations aggravated by sickle cell-related vaso-occlusive crises, including acute chest syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…26,27 The tracking system is based on gray-scale B-mode images and is obtained by automatic measurement of the distance between two pixels of an LV segment during the cardiac cycle, independent of the angle of insonation. The integration of 2D speckle tracking with real-time cardiac ultrasound imaging overcomes some of the limitations of previous work in the field and has the potential to provide a unified framework to more accurately quantify the regional and global function of the LV.…”

Section: Discussionmentioning

confidence: 99%

Left ventricular myocardial performance assessed by 2-dimensional speckle tracking echocardiography in patients with sickle cell crisis

Sengupta¹,

Jaju²,

Nugurwar³

et al. 2012

Indian Heart Journal

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“…On the other hand, recurrent occlusions of the coronary microcirculation due to sickling episodes may also characterize a decisive event in the cardiac findings of the disease. Several studies have pointed to the presence of myocardial ischemia in SCA, both in children and adults with no risk factors for atherosclerosis [8][9][10] . For this reason, a sickle cell cardiomyopathy has already been proposed 11 .…”

Section: Introductionmentioning

confidence: 99%