Myocardial Ischaemia Associated With General Anaesthesia

Reiz, S.

doi:10.1093/bja/61.1.68

Cited by 15 publications

(1 citation statement)

References 68 publications

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“…[15] Although it has been suggested that isoflurane may produce a 'coronary steal' phenomenon by redistributing blood flow in patients with fixed coronary stenotic lesions, [16] this is unlikely to occur at sedative doses. [17] Like halothane and enflurane, isoflurane may prevent or reverse bronchospasm by a variety of mechanisms, [18] leading to potentially beneficial effects in mechanically ventilated patients. As only 0.2% of an absorbed dose of isoflurane undergoes biotransformation, inorganic fluoride ion nephrotoxicity is unlikely.…”

Section: Isofluranementioning

confidence: 99%

Inhalation Anaesthetics as Sedatives in the Intensive Care Unit

Rasanayagam

Kong

2000

CNS Drugs

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Many different drugs are used for sedation of patients in the intensive care unit (ICU). The vast majority of the agents used are administered intravenously; however, for the purposes of sedation, inhalational anaesthetic agents have some advantages, and potential disadvantages, over intravenous drugs. There has been some published work on the use of isoflurane as a sedative agent in this situation, with favourable comparisons with the currently used intravenous drugs. Ultimately, the role of inhalational agents as sedatives in the ICU will depend on the development of appropriate equipment and the enthusiasm of the clinicians involved.

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