Myocardial Iron Overload Causes Subclinical Myocardial Dysfunction in Sickle Cell Disease

Fujikura, Kana; Cheng, Andrew L.; Suriany, Silvie; Detterich, Jon; Arai, Andrew E; Wood, John C.

doi:10.1016/j.jcmg.2022.02.019

Cited by 3 publications

(4 citation statements)

References 6 publications

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“…( Schmidt et al, 2021 , Schmidt et al, 2023 ). This is mirrored in conditions like thalassemia and hereditary hemochromatosis ( Wang et al, 2017 , Ginwalla et al, 2018 , Sumneang et al, 2020 , Fujikura et al, 2022 , Wood, 2023 ), as well as in myocardial infarction, reperfusion injuries, and heart failure ( Fang et al, 2023 , Wang et al, 2023a ), highlighting a pattern of cardiac iron toxicity.…”

Section: Ferroptosis – Vaso-occlusion and Hemolysis In Scdmentioning

confidence: 97%

Ferroptosis as an emerging target in sickle cell disease

Fortuna,

Lima,

Oliveira

et al. 2024

Current Research in Toxicology

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Section: Ferroptosis – Vaso-occlusion and Hemolysis In Scdmentioning

confidence: 97%

Ferroptosis as an emerging target in sickle cell disease

Fortuna,

Lima,

Oliveira

et al. 2024

Current Research in Toxicology

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“… 185 , 186 SCD is a classic Mendelian disease that often causes acute and chronic end‐organ damage. 187 , 188 Its typical clinical feature is acute pain. 189 During the disease, complications such as stroke, 190 kidney disease, 191 acute lung injury, 192 myocardial injury, 193 arrhythmia, and sudden death may also occur.…”

Section: Gene Therapy In Human Diseasesmentioning

confidence: 99%

CRISPR technology in human diseases

Feng,

Li,

Zhou

et al. 2024

MedComm

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Gene editing is a growing gene engineering technique that allows accurate editing of a broad spectrum of gene‐regulated diseases to achieve curative treatment and also has the potential to be used as an adjunct to the conventional treatment of diseases. Gene editing technology, mainly based on clustered regularly interspaced palindromic repeats (CRISPR)–CRISPR‐associated protein systems, which is capable of generating genetic modifications in somatic cells, provides a promising new strategy for gene therapy for a wide range of human diseases. Currently, gene editing technology shows great application prospects in a variety of human diseases, not only in therapeutic potential but also in the construction of animal models of human diseases. This paper describes the application of gene editing technology in hematological diseases, solid tumors, immune disorders, ophthalmological diseases, and metabolic diseases; focuses on the therapeutic strategies of gene editing technology in sickle cell disease; provides an overview of the role of gene editing technology in the construction of animal models of human diseases; and discusses the limitations of gene editing technology in the treatment of diseases, which is intended to provide an important reference for the applications of gene editing technology in the human disease.

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“…5,6 For example, Fe causes anemia, hemochromatosis, and genetic mutation. 7 Other metal ions such as Cr(VI), Hg, Co, Pb, and Cd also have adverse effects and cause major diseases affecting organs such as the liver, kidney, bone marrow, heart muscles, and neurons and genotoxicity. 8−15 Moreover, As(III) and As(V) cause cancer (arsenicosis).…”

Section: Introductionmentioning

confidence: 99%

“…The major sources of the pollutant are various natural (biogeochemical processes) and anthropogenic activities. The heavy metals are hazardous to health and nonbiodegradable and undergo bioaccumulation and biomagnification through the food chain. − These metal ions cause various diseases in deficiency or at a higher concentration than the permissible limit. , For example, Fe causes anemia, hemochromatosis, and genetic mutation . Other metal ions such as Cr(VI), Hg, Co, Pb, and Cd also have adverse effects and cause major diseases affecting organs such as the liver, kidney, bone marrow, heart muscles, and neurons and genotoxicity. − Moreover, As(III) and As(V) cause cancer (arsenicosis). , In order to remove metal ions from water, several modified adsorbent materials are used, like graphene/GO, biochars, and other nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Efficient Adsorption of Toxic Heavy Metal Ions on the Surface Engineered Violuric Acid-Reduced Graphene Oxide Nanomaterial

Kumar

Das

2023

ACS Appl. Eng. Mater.

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Herein, a surface-engineered violuric acid-functionalized reduced graphene oxide (rGO-VA) has been synthesized and characterized using XRD, FESEM, HRTEM-EDX, FTIR, XPS, Raman, and UV−vis spectroscopy. The surface morphology describes highly exfoliated graphene sheets and uniformly distributed VA showing a topography of average size ∼1.663 nm. The Raman and EDX spectra describe greater defects due to the presence of C, N, and O atoms on the surface of the rGO-VA. Hence, O and N-containing functional groups that are present on the surface and edge of rGO-VA facilitate the efficient adsorption of toxic metal ions. The synthesized rGO-VA efficiently removes metal ions up to 99.9% of Hg 2+ , Pb 2+ , and As 3+ , from their aqueous solutions (40 mg/L) within a short retention time (5−10 min). The removal efficiency results are unaffected even at various interferences like pH, temperature, organic pollutants, cations, and anions. The adsorption process is chemisorption, multilayer, spontaneous, endothermic, and random. During the adsorption process, the residual concentrations were initially analyzed using UV−vis spectroscopy, and the results were verified by AAS. Overall, the present surface-engineered rGO-VA may be crucial for developing an efficient adsorbent to remove toxic metal ions from wastewater.

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Myocardial Iron Overload Causes Subclinical Myocardial Dysfunction in Sickle Cell Disease

Cited by 3 publications

References 6 publications

Ferroptosis as an emerging target in sickle cell disease

Ferroptosis as an emerging target in sickle cell disease

CRISPR technology in human diseases

Efficient Adsorption of Toxic Heavy Metal Ions on the Surface Engineered Violuric Acid-Reduced Graphene Oxide Nanomaterial

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