Myocardial Injury on CMR in Patients With COVID-19 and Suspected Cardiac Involvement

Vidula, Mahesh K.; Rajewska-Tabor, Justyna; Cao, Jie J; Kang, Yu Min; Craft, Jason; Mei, Winifred; Chandrasekaran, Preethi S.; Clark, Daniel E.; Poenar, Ana-Maria; Gorecka, Miroslawa; Malahfji, Maan; Cowan, Eilidh; Kwan, Jennifer M.; Reinhardt, Samuel W.; Al-Tabatabaee, Sarah; Doeblin, Patrick; Villa, Adriana; Karagodin, Ilya; Alvi, Nazia; Christia, Panagiota; Spetko, Nicholas; Cassar, Mark Philip; Park, Christine; Nambiar, Lakshmi; Turgut, Alper; Azad, Mahan Roosta; Lambers, Moritz; Wong, Timothy C.; Salerno, Michael; Kim, Jiwon; Elliott, Michael D.; Raman, Betty; Neubauer, Stefan; Tsao, Connie W.; LaRocca, Gina; Patel, Amit R.; Chiribiri, Amedeo; Kelle, Sebastian; Baldassarre, Lauren A.; Shah, Dipan J.; Hughes, Sean G; Tong, Matthew; Pyda, Małgorzata; Simonetti, Orlando P.; Plein, Sven; Han, Yuchi

doi:10.1016/j.jcmg.2022.10.021

Cited by 17 publications

(17 citation statements)

References 30 publications

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“…The study by Vidula et al 5 strengthens some of these previous findings by conducting an analysis of a large multicenter clinical collective. The study analyzed the outcomes of 1,047 clinical CMR scans of patients with COVID-19 presenting to cardiology services on average 132 ± 95 days from the infection using guideline-related indications (raised troponin, electrocardiogram [ECG] abnormalities, ischemia-like or heart failure symptoms).…”

supporting

confidence: 60%

Toward Better Understanding of Cardiac Involvement Post COVID

Püntmann

Nagel

2023

JACC: Cardiovascular Imaging

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supporting

confidence: 60%

Toward Better Understanding of Cardiac Involvement Post COVID

Püntmann

Nagel

2023

JACC: Cardiovascular Imaging

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“…In our cohort patients with LV dysfunction were more likely hospitalized and were intubated 16 . Second, patients could have had myocarditis after the acute SARS‐CoV2 infection, however, in our cohort we did not find any residual damage as manifested by the lack of LGE on cardiac MRI 2 . Third, SARS‐CoV2 causes endothelial damage and microclots and this could lead to vascular disease and organ damage 17 .…”

Section: Discussionmentioning

confidence: 62%

“…16 Second, patients could have had myocarditis after the acute SARS-CoV2 infection, however, in our cohort we did not find any residual damage as manifested by the lack of LGE on cardiac MRI. 2 Third, SARS-CoV2 causes endothelial damage and microclots and this could lead to vascular disease and organ damage. 17 An alternative explanation could be that due to a high cardiovascular risk burden, There are several limitations that deserve mention.…”

Section: Variablesmentioning

confidence: 99%

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Cardiovascular risk factors predict who should have echocardiographic evaluation in long COVID

Tamariz,

Ryan,

Marzouka

et al. 2024

Echocardiography

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BackgroundThe need for echocardiograms among patients with long COVID is debatable. Our aim was to evaluate the prevalence of left ventricular (LV) dysfunction and identify predictors.MethodsWe conducted a cross‐sectional study and included all consecutive patients enrolled in our post‐COVID clinic. We included patients who had an echocardiogram and had no previous known heart disease. We defined LV dysfunction as a low ejection fraction or grade II to grade III diastolic dysfunction on an echocardiogram with evidence of elevated filling pressures. We calculated the prevalence of heart disease and predictors of heart disease using logistic regression.ResultsWe included 217 post‐COVID patients enrolled in the clinic. The prevalence of LV dysfunction is 24%; 95% CI 18–30. Predictors of heart disease include older age and a previous history of hypertension and diabetes or having an intermediate or high ASCVD score. Patients with low ASCVD score did not have low ejection fraction on the screening echocardiograms.ConclusionOur study found a considerable number of patients with LV dysfunction. Older patients with cardiovascular risk factors are at risk of long COVID associated heart disease.

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“…18,19 The most recent American Heart Association/American College of Cardiology clinical practice guidelines do not make COVID-specific suggestions, but recommend CCTA as a useful means of excluding obstructive CAD in certain intermediate-risk patients with acute chest pain with or without known CAD. 104 Numerous studies have demonstrated the high diagnostic accuracy of CCTA to ruleout clinically significant coronary artery disease among patients hospitalized with non-ST-segment-elevation ACS. 105 In addition to high-resolution anatomic assessment, CT-derived fractional flow reserve has emerged as an effective means of noninvasively assessing hemodynamic abnormalities related to any observed anatomic stenoses, although the added acquisition time may limit its deployment in COVID.…”

Section: Ischemic and Thrombotic Complications Of Covidmentioning

confidence: 99%

Multimodality Cardiac Imaging in COVID

Holby

Richardson

Laws

et al. 2023

Circulation Research

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Infection with SARS-CoV-2, the virus that causes COVID, is associated with numerous potential secondary complications. Global efforts have been dedicated to understanding the myriad potential cardiovascular sequelae which may occur during acute infection, convalescence, or recovery. Because patients often present with nonspecific symptoms and laboratory findings, cardiac imaging has emerged as an important tool for the discrimination of pulmonary and cardiovascular complications of this disease. The clinician investigating a potential COVID-related complication must account not only for the relative utility of various cardiac imaging modalities but also for the risk of infectious exposure to staff and other patients. Extraordinary clinical and scholarly efforts have brought the international medical community closer to a consensus on the appropriate indications for diagnostic cardiac imaging during this protracted pandemic. In this review, we summarize the existing literature and reference major societal guidelines to provide an overview of the indications and utility of echocardiography, nuclear imaging, cardiac computed tomography, and cardiac magnetic resonance imaging for the diagnosis of cardiovascular complications of COVID.

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Myocardial Injury on CMR in Patients With COVID-19 and Suspected Cardiac Involvement

Cited by 17 publications

References 30 publications

Toward Better Understanding of Cardiac Involvement Post COVID

Toward Better Understanding of Cardiac Involvement Post COVID

Cardiovascular risk factors predict who should have echocardiographic evaluation in long COVID

Multimodality Cardiac Imaging in COVID

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