Myocardial injury and fibrogenesis: extracellular volume expansion is associated with elevated Galectin-3 levels in patients with myocarditis

Radziwolek, Lukas; Radunski, Ulf K; Koopmann, Katharina; Bohnen, Sebastian; Zeller, Tanja; Lund, Gunnar; Krull, Aljoscha D; Hauschild, Nina; Stehning, Christian; Adam, Gerhard; Blankenberg, Stefan; Muellerleile, Kai

doi:10.1186/1532-429x-16-s1-p290

Cited by 3 publications

(1 citation statement)

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“…Cross-reacting antibodies with auto-antigens have also been found in patients with myocarditis ( 15 ). In the third phase, the intensity of the immune response is downregulated and fibrosis starts ( 16 , 17 ). As a result, the persistent low-grade immune response leads to extensive myocardial injury and, eventually, dilated cardiomyopathy ( 17 , 18 ).…”

Section: Discussionmentioning

confidence: 99%

Acute myocarditis mimicking ST-elevation myocardial infarction: A case report and review of the literature

Zhang

Miao

Wang³

et al. 2015

Experimental and Therapeutic Medicine

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The present study describes the case of a young man aged 22 who had acute retrosternal pain, elevated cardiac markers and electrocardiographic ST-T changes, which led to an original misdiagnosis of acute myocardial infarction. The patient underwent immediate coronary angiography, which revealed normal coronary arteries. Finally, the diagnosis of viral myocarditis was made on consideration of his fever, scattered red dots on his arms and legs and other auxiliary examination results obtained in the following days, which were supportive of the diagnosis. The patient improved on antiviral and myocardial protection therapy and was discharged 2 weeks later. Viral myocarditis is a common disease with a variable natural history. It remains challenging for doctors to differentiate between acute myocarditis and myocardial infarction, particularly in the early stages. A diagnosis of myocarditis should be made on the basis of synthetic evaluation of the evidence, including medical history, clinical presentation and results of the available auxiliary tests, in order to provide guidelines for treatment.

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Section: Discussionmentioning

confidence: 99%

Acute myocarditis mimicking ST-elevation myocardial infarction: A case report and review of the literature

Zhang

Miao

Wang³

et al. 2015

Experimental and Therapeutic Medicine

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Evaluation of cardiac fibrosis and subclinical cardiac changes in children with sickle cell disease using magnetic resonance imaging, echocardiography, and serum galectin-3

Wagdy,

Fathy,

Elnekidy

et al. 2023

Pediatr Radiol

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Background Myocardial fibrosis has recently been proposed as one of the contributing factors to the diverse pathogenicity of cardiomyopathy in sickle cell disease. Objective In this study, cardiac fibrosis and subclinical cardiac changes in children with sickle cell disease were evaluated using cardiac magnetic resonance imaging (MRI), tissue Doppler echocardiography and serum galectin-3. Materials and methods The study included 34 children with sickle cell disease who were compared with a similar number of healthy controls. Cardiac MRI was used to evaluate late gadolinium enhancement, native T1 mapping, extracellular volume, and T2* for estimation of iron load. Cardiac function and myocardial performance index (MPI, evaluated by tissue Doppler echocardiography) and serum galectin-3 were compared to controls. Results The mean age of the included patients was 13.3 ± 3.2 years. Myocardial iron load by T2* was normal. The mean level of extracellular volume (35.41 ± 5.02%) was significantly associated with the frequency of vaso-occlusive crises (P = 0.017) and negatively correlated with hemoglobin levels (P = 0.005). Galectin-3 levels were significantly higher among cases than controls (P = 0.00), at a cutoff value on the receiver operating characteristic curve of 6.5 ng/ml, sensitivity of 82.5% and specificity of 72.8%. The extracellular volume was significantly higher in cases, with a MPI > 0.4. Conclusion Diffuse interstitial myocardial fibrosis can be detected early in children with sickle cell disease using T1 mapping and is associated with a high frequency of vaso-occlusive crisis. MPI of the left ventricle and serum galectin-3 are recommended screening tools for subclinical cardiac abnormalities. Graphical abstract

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Galectin-3 as a Biomarker of Heart Failure in Children with Congenital Heart Disease

Elhewala¹,

Ibrahem²,

Hafez³

2020

The Egyptian Journal of Hospital Medicine

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Myocardial injury and fibrogenesis: extracellular volume expansion is associated with elevated Galectin-3 levels in patients with myocarditis

Cited by 3 publications

References 0 publications

Acute myocarditis mimicking ST-elevation myocardial infarction: A case report and review of the literature

Acute myocarditis mimicking ST-elevation myocardial infarction: A case report and review of the literature

Evaluation of cardiac fibrosis and subclinical cardiac changes in children with sickle cell disease using magnetic resonance imaging, echocardiography, and serum galectin-3

Galectin-3 as a Biomarker of Heart Failure in Children with Congenital Heart Disease

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