Myocardial Infarction in Pulmonary Emphysema

Samad, Iqbal A.; Noehren, Theodore H.

doi:10.1378/chest.47.1.26

Cited by 14 publications

(3 citation statements)

References 8 publications

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“…Patients with COPD frequently had congestive heart failure (CHF) during hospitalization (25.8% vs 15.7%, P = 0.001), with no statistical difference in cardiogenic shock, inhospital mortality rate, stroke, or reinfarction. COPD patients had longer hospital stays than non-COPD patients (7 days [4-8] vs 6 days [3][4][5][6][7], P = 0.001), and in the STEMI group the incidence of major bleeding complications was higher in the COPD group (2.8% vs 1%, P = 0.04), despite the fact that these patients were less likely to receive thrombolytic therapy.…”

Section: In-hospital Treatment and Outcomementioning

confidence: 99%

“…[1][2][3][4][5][6] In a recent large cohort of nearly 400 000 veterans with COPD admitted to a Veterans Administration (VA) hospital, the prevalence of coronary artery disease (CAD) was 33.6%, significantly higher than the prevalence seen in a matched cohort without COPD (27.1%). 7 Other investigators confirmed the high prevalence of CAD in patients with COPD.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and Prognosis of Chronic Obstructive Pulmonary Disease Among 8167 Middle Eastern Patients With Acute Coronary Syndrome

Hadi

Zubaid²,

Mahmeed

et al. 2010

Clinical Cardiology

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Background: The purpose of this study was to report the prevalence and the significance of clinically recognized chronic obstructive pulmonary disease (COPD) during acute coronary syndrome (ACS). Hypothesis: COPD in patients with ACS is associated with worse outcome. Methods: Data were derived from a prospective, multicenter, multinationalstudy of 8167 consecutive patients hospitalized with ACS from February to June 2007 in 6 Middle Eastern countries. Data were analyzed according to the presence or absence of COPD. Demographic, management, and in-hospital outcomes were compared. Results: The prevalence of COPD was 5.3%. When compared with non-COPD patients, COPD patients were older and more likely to have diabetes, hypertension, and dyslipidemia. Atypical presentations were more common in COPD patients (P = 0.001). COPD patients were less likely to be treated with thrombolytic therapy (P = 0.001), β-blockers (P = 0.001), and glycoprotein IIb/IIIa inhibitors, and more likely to receive angiotensin-converting enzyme (ACE) inhibitors. Although there was no difference in in-hospital mortality between the 2 groups, patients with COPD were more likely to have heart failure (P = 0.001). Despite the fact that COPD patients with ST-segment elevation myocardial infarction were less likely to receive thrombolytic therapy, they suffered more bleeding complications (2.8% vs 1%, P = 0.04), resulting in prolonged hospitalization. COPD was not an independent predictor of increased in-hospital mortality. Conclusions: In this large cohort of patients with ACS, the prevalence of COPD was 5·3%. Atypical presentation is common among COPD patients, and this may result in delayed therapy. ACS in COPD patients was associated with higher risk of heart failure and major bleeding complications without increased risk of in-hospital mortality.

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Section: In-hospital Treatment and Outcomementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence and Prognosis of Chronic Obstructive Pulmonary Disease Among 8167 Middle Eastern Patients With Acute Coronary Syndrome

Hadi

Zubaid²,

Mahmeed

et al. 2010

Clinical Cardiology

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“…However, it has been repeatedly demonstrated that the incidence of myocardial infarction in COPD is less than in the general population of comparable age (Nonkin, Dick & Baum, 1964;KrBlovB, Jeiek, Linhartovh & StCphnek, 1965;Samad & Noehren, 1965;Mitchell, Walker & Maisel, 1968).…”

Section: Presence Of Atherosclerotic Heart Diseasementioning

confidence: 99%

Left Ventricular Function in Chronic Obstructive Pulmonary Disease with and without Cardiac Failure

Jezek

Schrijen

1973

Clinical Science

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1. The circulatory response to supine exercise and to angiotensin infusion was measured in patients with chronic obstructive pulmonary disease (COPD).2. Left ventricular function assessed from left ventricular end-diastolic pressure (LVEDPFstroke volume or stroke work relationships was almost always normal in the patients without cardiac failure. The patients with right heart failure showed an abnormal response with a pronounced rise of LVEDP during both exercise and infusion of angiotensin. The values of LVEDP showed a significant correlation with RVEDP and with arterial oxygen saturation and carbon dioxide tension under both experimental conditions. No abnormality in the response of cardiac output, mean systolic ejection ratio or systolic ejection time was observed. In thirteen out of fifteen patients subjected to both exercise and infusion of angiotensin, the results of the two tests agreed in showing left ventricular function to be normal or abnormal; two patients showed an abnormal response to exercise, but a normal response to angiotension.3. The possible causes of the abnormality of left ventricular function in COPD with right heart failure are discussed. Changes in left ventricular compliance and the effect of chronic hypoxaemia and hypercapnic acidosis on myocardial contractility seem to be the most probable explanation.

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The Left Ventricle in Chronic Lung Disease

Caldwell¹

1984

Pulmonary Heart Disease

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Myocardial Infarction in Pulmonary Emphysema

Cited by 14 publications

References 8 publications

Prevalence and Prognosis of Chronic Obstructive Pulmonary Disease Among 8167 Middle Eastern Patients With Acute Coronary Syndrome

Prevalence and Prognosis of Chronic Obstructive Pulmonary Disease Among 8167 Middle Eastern Patients With Acute Coronary Syndrome

Left Ventricular Function in Chronic Obstructive Pulmonary Disease with and without Cardiac Failure

The Left Ventricle in Chronic Lung Disease

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