Myocardial infarction complicating neonatal enterovirus myocarditis

Hornung, TS; Ej, Bernard; Howman-Giles, R; Gf, Sholler

doi:10.1046/j.1440-1754.1999.00316.x

Cited by 25 publications

(19 citation statements)

References 8 publications

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“…This myocellular damage leads to myocardial dysfunction and consequently heart failure, dysrhythmias or even mimicking myocardial infarction 14. The optimal management of these patients remains controversial and predominantly consists of supportive care.…”

Section: Discussionmentioning

confidence: 99%

Extracorporeal membrane oxygenation for neonatal collapse caused by enterovirus myocarditis

Cortina

Best

Deisenberg

et al. 2017

Arch Dis Child Fetal Neonatal Ed

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In this case series, ECMO initiation prevented further deterioration and cardiac arrest in neonates with severe EV myocarditis and not responding to conventional medical therapies. Moreover, complete cardiac recovery occurred in survivors. However, these neonates may need long ECMO runs and are at increased risk for mechanical complications. Furthermore, mortality remains high due to greater disease severity.

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Section: Discussionmentioning

confidence: 99%

Extracorporeal membrane oxygenation for neonatal collapse caused by enterovirus myocarditis

Cortina

Best

Deisenberg

et al. 2017

Arch Dis Child Fetal Neonatal Ed

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“…Neither of the babies who had mild disease at onset developed myocarditis. The association between coxsackie B virus infection, myocardial involvement and mortality is well recognised, especially when coagulopathy coexists [1,16,17,19,20,27,30,31,52]. In contrast to infection with echoviruses, only two of the ten cases had hepatitis, both of whom had severe disease.…”

Section: Mortalitymentioning

confidence: 99%

Neonatal coxsackie B virus infection?a treatable disease?

Bryant

Tingay

Dargaville

et al. 2004

European Journal of Pediatrics

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Ten neonates with coxsackie B viral infection presented over a 3-month period. Clinical features included meningoencephalitis, thrombocytopenia, disseminated intravascular coagulopathy, cardiomyopathy, and hepatitis. Eight infants had multiorgan disease, four with severe myocardial dysfunction, of whom two died. All of the infants with severe disease developed symptoms within 7 days of age. In infants presenting within 10 days of birth, in all cases there were symptoms compatible with maternal infection prior to delivery. Severity was associated with perinatal transmission. Enteroviral polymerase chain reaction of CSF, urine, stool or throat swab was positive in nine of the ten babies. Seven of the infants were treated with a 7-day course of the new anti-picornaviral drug pleconaril (5 mg/kg 3 times daily). Conclusion: These cases highlight the importance of not missing coxsackie B viral infection in the differential diagnosis of the septic neonate, especially as there is now a potential treatment.

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“…This myocyte necrosis is mimicking myocardial infarction and will be replaced by a scar. Later in life this may turn into an aneurysm of the left ventricle as it frequently occurs in patients with myocardial infarction 15 16 26. Akinetic, hypokinetic and hyperechogenic areas within the left ventricle on echocardiography as shown in figure 1, have been found in all seven infants with EV myocarditis.…”

Section: Discussionmentioning

confidence: 87%