Myocardial HLA-G Reliably Indicates a Low Risk of Acute Cellular Rejection in Heart Transplant Recipients

Sheshgiri, Rohit; Rouas‐Freiss, Nathalie; Rao, Vivek; Butany, Jagdish; Ramzy, Danny; Krawice-Radanne, Irène; Ross, Heather J.; Carosella, Edgardo D.; Delgado, Diego

doi:10.1016/j.healun.2008.02.004

Cited by 44 publications

(39 citation statements)

References 30 publications

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“…Several studies have described a protective effect of HLA-G in human allotransplantation such as kidney, liver, heart and lung [6,[17][18][19]. In kidney transplant patients, increased soluble HLA-G level was significantly associated with better graft acceptance [8,18,[20][21][22][23].…”

Section: Genotyping Of Hla-g 14 Bp Polymorphism At Exon 8 (3´ Utr)mentioning

confidence: 99%

Impact of HLA-G 14 bp polymorphism and soluble HLA-G level on kidney graft outcome

Ďurmanová

Bandžuchová²,

Žilinská

et al. 2016

Open Life Sciences

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Human leukocyte antigen G (HLA-G) is a non-classical HLA class I protein with various immunosuppressive functions. Besides its profound effect to induce fetal tolerance, HLA-G has been also found to enhance graft acceptance. The aim of the study was to analyse the association between HLA-G 14 bp insertion/deletion polymorphism, soluble HLA-G level and kidney graft outcome in the Slovak population. We investigated 69 kidney transplant recipients aged 27–65 years. Out of this group, 37 recipients developed acute rejection, confirmed by biopsy, and 32 patients had stable allograft function. Plasma was obtained from recipients at 1 day before transplantation and analyzed by ELISA. Genotyping of HLA-G polymorphism was performed by PCR. Significantly higher pre-transplantation levels of sHLA-G were found in the group with stable allograft function in comparison to group with acute rejection (P = 0.0409). In the homozygous −14/−14 recipients with stable allograft function, significantly higher values of sHLA-G were determined in comparison to the recipients with acute rejection (P = 0.0052). The study revealed an association between 14 bp deletion polymorphism and soluble HLA-G level that is proportional to kidney graft acceptance. It is suggested that pre-transplantation levels of soluble HLA-G should be monitored as additional marker to predict kidney graft outcome.

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Section: Genotyping Of Hla-g 14 Bp Polymorphism At Exon 8 (3´ Utr)mentioning

confidence: 99%

Impact of HLA-G 14 bp polymorphism and soluble HLA-G level on kidney graft outcome

Ďurmanová

Bandžuchová²,

Žilinská

et al. 2016

Open Life Sciences

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“…(32,33). The nongenetic factors known to promote HLA-G expression include stress (34), steroids (35), cyclosporine A (9), the proinflammatory cytokine and the suppressive cytokine (6,7,13 (13,14), and since previous pregnancy in female patients does not seem to influence HLA-G expression (10).…”

Section: The Significance Of the Bronchial Expression Of Hla-g In Stamentioning

confidence: 99%

Immunohistochemical Study of HLA-G Expression in Lung Transplant Recipients

Brugière

Thabut

Pretolani

et al. 2009

American Journal of Transplantation

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“…3 It must be noted that, in these cases, expression of HLA-G was detected in situ in cells that are the primary targets of the immune system, e.g endomyocardial cells in heart grafts, 11,37 biliary epithelial cells in liver transplants , 12 and tubular epithelial cells after kidney transplantation. 35 Despite the large amount of information concerning HLA-G expression in solid organ transplantation, there have been no similar studies in the allogeneic hematopoietic cell transplantation (allo-HCT) setting.…”

Section: Discussionmentioning

confidence: 99%

“…Beyond physiological conditions, ectopic HLA-G expression has been found in tumor cells, 9 virus infected cells, 7 transplanted organs or immune cells infiltrating grafts, 3 and has been suggested to constitute an immune escape mechanism. After solid organ transplantation, HLA-G expression by the transplant organ [10][11][12] and high soluble HLA-G plasma levels 13,14 have been associated with better graft acceptance. After allogeneic bone marrow transplantation, soluble HLA-G plasma levels have been suggested to correlate with the occurrence of acute graft-versus-host disease (GvHD), suggesting an involvement of HLA-G in GvHD prevention.…”

Section: Introductionmentioning

confidence: 99%

Identification of a novel HLA-G+ regulatory population in blood: expansion after allogeneic transplantation and de novo HLA-G expression at graft-versus-host disease sites

Λαζανά¹,

Zoudiari²,

Kokkinou³

et al. 2012

Haematologica

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Myocardial HLA-G Reliably Indicates a Low Risk of Acute Cellular Rejection in Heart Transplant Recipients

Cited by 44 publications

References 30 publications

Impact of HLA-G 14 bp polymorphism and soluble HLA-G level on kidney graft outcome

Impact of HLA-G 14 bp polymorphism and soluble HLA-G level on kidney graft outcome

Immunohistochemical Study of HLA-G Expression in Lung Transplant Recipients

Identification of a novel HLA-G+ regulatory population in blood: expansion after allogeneic transplantation and de novo HLA-G expression at graft-versus-host disease sites

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