Myocardial glycoprotein changes with isoproterenol-induced necrosis and repair in the rat

Abstract

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

Antioxidant Potential of a Novel Tetrapeptide Derivative in Isoproterenol-Induced Myocardial Necrosis in Rats

“…As a result, the rats exhibit signs of shock, dyspnea, lethargy and prostration during the first few hours of ISO injection, but these observations are not observed in PEP1261 and ASA pre-treatment as well as in pre-and post-treatment. The increase in the wet weight of myocardium after ISO administration, as shown in this study, might be due to the increased water content and edematous intramuscular fibers followed by invasion of the damage tissue by inflammatory cell exudate [22]. PEP1261 pre-and post-treatment is found to protect the myocardium against infiltration and decreases the water content of the myocardium.…”

Cardio Protective Effect of Vitamin A against Isoproterenol-Induced Myocardial Infarction

“…The increase in heart weight might be attributed to increased water content, edematous intramuscular space and increased protein content (20). These results are in consistent with a previous report (21), which has observed extensive edematous intramuscular space, accumulation of mucopolysaccharides and cellular infiltration after 4 h of induction of myocardial infarction. It has been proposed that a 1% increase in myocardial water content could be expected to result in possibly a 10% reduction in myocardial function (22).…”

Comparative evaluation of HMG CoA reductase inhibitors in experimentally-induced myocardial necrosis: Biochemical, morphological and histological studies

“…It has been reported that isoproterenol administration leads to cardiac necrosis by hypertrophy of cardiac muscles, increased water content in intracellular space, edematous tissue, accumulation of muco-polysaccharides and infiltration of inflammatory cells (Judd and Wexler, 1974;16 Upaganlawar et al, 2009). In present study we observed that, heart weight is significantly increased with relatively no change in body weight resulted into raise of heart weight to body weight ratio.…”