Myocardial function in infarcted and remote regions early after infarction in man: Assessment by magnetic resonance tagging and strain analysis

Marcus, J. Tim; Götte, Marco J.W.; Rossum, Albert C. van; Kuijer, Joost P.A.; Heethaar, R.M.; Axel, Leon; Visser, Cees A.

doi:10.1002/mrm.1910380517

Cited by 87 publications

(54 citation statements)

References 23 publications

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“…22 In humans, it has also previously been shown that regional blood flow in the remote zone is increased in infarcted hearts 23 and that those regions exhibit hyperfunction compared with controls. 23,24 Similarly, we found that the pattern of work done by the infarcted hearts was prominently different than in control hearts. cRMW L in the lateral wall (coincident with the infarcted region) was eliminated, and septal cRMW L was increased.…”

Section: Regional Workmentioning

confidence: 55%

Assessment of Regional Myocardial Work in Rats

Espe

Aronsen

Eriksen

et al. 2015

Circ: Cardiovascular Imaging

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Background-Left ventricular (LV) motion and deformation is dependent on mechanical load and do therefore not reflect myocardial energy consumption directly. Regional myocardial work, however, constitutes a more complete assessment of myocardial function. Methods and Results-Strain was measured using high-resolution phase-contrast MRI in 9 adult male rats with myocardial infarction (MI) and in 5 sham-operated control animals. Timing of LV valvular events and LV dimensions were evaluated by cine MRI. A separate cohort of 14 animals (MI/sham=9/5) underwent measurement of LV pressure concurrent with identification of valvular events by Doppler-echocardiography for the purpose of generating a standard LV pressure curve, normalized to valvular events. The infarctions were localized to the anterolateral LV wall. Combining strain with timing of valvular events and a measurement of peak arterial pressure, regional myocardial work could be calculated by applying the standard LV pressure curves. Cardiac output and stroke work was preserved in the MI hearts, suggesting a compensatory redistribution of myocardial work from the infarcted region to the viable tissue. In the septum, regional work was indeed increased in MI rats compared with sham (median work per unit long-axis length in a mid-ventricular slice: 241. Additionally, eccentric work was increased in the MI hearts. Conclusions-Phase-contrast MRI, in combination with measurement of peak arterial pressure and MRI-derived timing of valvular events, represent a noninvasive approach for estimation of regional myocardial work in rodents.

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Section: Regional Workmentioning

confidence: 55%

Assessment of Regional Myocardial Work in Rats

Espe

Aronsen

Eriksen

et al. 2015

Circ: Cardiovascular Imaging

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“…Depolarization is followed by contraction of the myofibers. The normal contraction pattern of the left ventricle ͑LV͒ may be affected by underperfusion 2,15,25,52 and abnormal conduction of the depolarization wave. 34,53 With the rapid evolution of methods to determine myocardial deformation non-invasively, deduction of pathology from such measurements is a challenge.…”

Section: Introductionmentioning

confidence: 99%

Homogeneity of Cardiac Contraction Despite Physiological Asynchrony of Depolarization: A Model Study

Kerckhoffs

Bovendeerd

Kotte

et al. 2003

Annals of Biomedical Engineering

162

139

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Abstract-The use of mathematical models combining wave propagation and wall mechanics may provide new insights in the interpretation of cardiac deformation toward various forms of cardiac pathology. In the present study we investigated whether combining accepted mechanisms on propagation of the depolarization wave, time variant mechanical properties of cardiac tissue after depolarization, and hemodynamic load of the left ventricle ͑LV͒ by the aortic impedance in a threedimensional finite element model results in a physiological pattern of cardiac contraction. We assumed that the delay between depolarization for all myocytes and the onset of crossbridge formation was constant. Two simulations were performed, one in which contraction was initiated according to the regular depolarization pattern ͑NORM simulation͒, and another in which contraction was initiated after synchronous depolarization ͑SYNC simulation͒. In the NORM simulation propagation of depolarization was physiological, but wall strain was unphysiologically inhomogeneous. When simulating LV mechanics with unphysiological synchronous depolarization ͑SYNC͒ myofiber strain was more homogeneous and more physiologic. Apparently, the assumption of a constant delay between depolarization and onset of crossbridge formation results in an unrealistic contraction pattern. The present finding may indicate that electromechanical delay times are heterogeneously distributed, such that a contraction in a normal heart is more synchronous than depolarization.

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“…Fig. 2(a) shows the first principal strain maps for visual comparisons, as there is a strong inverse relation between the first principal strain and the extent of myocardial infarction [9]. There is almost no deformation in the infarcted regions in the ground truth.…”

Section: Synthetic Datamentioning

confidence: 99%

A Comparative Study of Physiological Models on Cardiac Deformation Recovery: Effects of Biomechanical Constraints

Wong

Wang

Liu

et al. 2011

Lecture Notes in Computer Science

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Abstract. Cardiac deformation recovery is to recover quantitative subject-specific myocardial deformation from imaging data. In the last decade, cardiac physiological models derived from anatomy, biomechanics, and cardiac electrophysiology have become increasingly popular in constraining the recovery problems because of their physiological meaningfulness. Although physiological models with various electrical and biomechanical components have been adopted by different frameworks and have exhibited promising results, these models have not been systematically compared under the same recovery framework, input data, and experimental setups. As different models comprise varying physiological plausibilities and complexities, comparisons under the same settings can aid choosing the proper models for specific goals and available resources. In this paper, under a state-space filtering framework for statistically optimal couplings between models and image data, we compare the performances of six different cardiac physiological models with different biomechanical constraints. Experiments were performed on synthetic data for quantitative comparisons, and on clinical data for their capabilities in identifying pathological situations.

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Myocardial function in infarcted and remote regions early after infarction in man: Assessment by magnetic resonance tagging and strain analysis

Cited by 87 publications

References 23 publications

Assessment of Regional Myocardial Work in Rats

Assessment of Regional Myocardial Work in Rats

Homogeneity of Cardiac Contraction Despite Physiological Asynchrony of Depolarization: A Model Study

A Comparative Study of Physiological Models on Cardiac Deformation Recovery: Effects of Biomechanical Constraints

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