Myocardial Function and Metabolism in the Conscious Dog and during Halothane Anesthesia

Merin, Robert G.; Kumazawa, Teruo; Luka, Norman L.

doi:10.1097/00000542-197605000-00009

Cited by 70 publications

(15 citation statements)

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“…This discrepancy may be attributed to the following factors : 1) An ordinary clinical dose as used in the present study caused only a slight increase in R value, and 2) in the present study comparison was made between different groups in contrast to the previous study. The result that R value for halothane anesthesia was not significantly different from those for the other intravenous anesthesia and similar to those for conscious dogs coincides with other previous reports (Merin et al 1976a;Yusa et al 1977).…”

Section: Discussionsupporting

confidence: 92%

Myocardial oxygen extraction rate under general anesthesia.

Yusa

Obara

1981

Tohoku J. Exp. Med.

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Section: Discussionsupporting

confidence: 92%

Myocardial oxygen extraction rate under general anesthesia.

Yusa

Obara

1981

Tohoku J. Exp. Med.

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“…Recently, Wu et al (9) reported that a high dose of OPC-18790 (3 mg/kg, i.v. ), similar to other drugs which increase calcium inward current, worsened halothane- (10) and acts to increase the arrhythmogenicity of catecholamines (11)(12)(13).…”

Section: Opc-18790 (±)-6-[3-(34-dimethoxybenzylamino)-2-hydroxypropmentioning

confidence: 85%

Cardiovascular Effects of the Combination of OPC-18790 and Dopamine in Halothane-Anesthetized Dogs

Itoh

Mori

Yoshida

et al. 1995

Japanese Journal of Pharmacology

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ABSTRACT-OPC-18790, (±)-6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]-2(1H)-quinolinone, is a novel positive inotropic agent, and its mechanism of positive inotropic action involves not only phosphodiesterase inhibition, but also a prolongation of action potential duration in ventricular muscle. Prolongation of action potential duration is also a property of class III antiarrhythmic agents; therefore, we examined the cardiohemodynamic effects and arrhythmogenicity of a combination of OPC-18790 and dopamine in halothane-anesthetized dogs. Dopamine (5 pg/kg/min) alone increased the peak of the first derivative of left ventricular pressure (LVdP/dtm ) and cardiac output (CO) by 43-48% and 16-20%, respectively, while OPC-18790 (10 pg/kg/min) increased these parameters by 56% and 22%, respectively. The combination of OPC-18790 (10 pg/kg/min) and dopamine (5 pg/kg/min) and dopamine alone at an increased dose of 10 ,pg/kg/min further increased LVdP/dtm , and CO by 104-113% and 29-30%, respectively. Thus, positive inotropic effects were equally observed in both groups, and the effects of OPC-18790 and dopamine seemed to be additive. The other hemodynamic effects were similar among all groups. Arrhythmias such as premature ventricular contraction developed in 5 out of 7 dogs (71.4%) in the 10-pg/kg/min dopamine group, while only one premature ventricular contraction was observed in 1 of 7 dogs (14.3%) in the OPC-18790 (10 pg/kg/min) and dopamine (5 pg/kg/min) combination group. These results suggest that the combination of OPC-18790 and dopamine may provide new therapeutic options for the treatment of heart failure.

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“…Finally, this study has deliberately excluded other factors well known to affect cellular energy status in vivo, such as compensatory ATP production via anaerobic glycolysis and parallel anesthetic inhibition of energy-using processes (7,8,22). The extent to which anesthetic effects on these other processes interact with the effects on mitochondrial energy generation reported herein remains an important topic for future experiments.…”

Section: Discussionmentioning

confidence: 99%

Effects of Halothane and Decreased PO2 on High Energy Phosphate Levels Maintained by Isolated Rat Liver Mitochondria

Becker

Miletich

Albrecht

1986

Anesthesia & Analgesia

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HECKER GL, MILETICI I DJ, ALBIIECHT RF Eftects of tialothane and decreased Po, on high energ\ pho5phate levds maintained by isolated rat liver initochondria Ane5th Analg 1986Analg ,65 1130 srrpportcd by NAD-linked substrate (glutamatc); sirccinates u p p r f e d ATPIAUP zurzs not ilihibitcd. With Either substnite, a r i d udictlier or riot 7 % lialuthnne was present, ATPI A D P wiis iinaffected by decreases in PO, to values as low (1s 1.6 mn [Icy. Undcr n rniige of typicd iri uivo conditions, tliereforc, 1 %-linlotlintir sigriificmitly inhibited the mitoclioridrinl cori/ribirtiorr to ste~zdy stnte e n e r a buluizcc., wliereus iiecmmcs i i i PO, did riot. Conzbiizcd effects of 1 % halothane nrid rcifirced PO? on ATPIADP were not seen, i.e., halothunc ifid not iricwnse the critical Pc) Iri.1el (Iiypoxic t h r e s~i~~l~~ f i i r inliiliititiii of rnitoclioiidrinl ATP production.

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Myocardial Function and Metabolism in the Conscious Dog and during Halothane Anesthesia

Cited by 70 publications

References 0 publications

Myocardial oxygen extraction rate under general anesthesia.

Myocardial oxygen extraction rate under general anesthesia.

Cardiovascular Effects of the Combination of OPC-18790 and Dopamine in Halothane-Anesthetized Dogs

Effects of Halothane and Decreased PO2 on High Energy Phosphate Levels Maintained by Isolated Rat Liver Mitochondria

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