Myocardial extraction of intracellular magnesium and atrial fibrillation after coronary surgery

Abdel-Massih, Tony; Sarkis, Antoine; Sleilaty, Ghassan; El‐Rassi, Issam; Chamandi, Chucralla; Karam, Nicole; Haddad, Fadia; Yazigi, Alexandre; Madi-Jebara, Samia; Yazbeck, Patricia; Asmar, Bechara El; Ashoush, Ramzi; Jebara, Victor A.

doi:10.1016/j.ijcard.2011.04.015

Cited by 7 publications

(2 citation statements)

References 24 publications

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“…These properties result in an anti-arrhythmic effect of Mg. Similar to esophageal cancer surgery, POAF is common after coronary artery bypass surgery, in which an association of hypomagnesemia and prevention of POAF by magnesium preparations have been shown [17][18][19]. However, tMg was examined in these studies and iMg was rarely measured, despite its association with physiological activity [20].…”

Section: Discussionmentioning

confidence: 99%

Ionized Hypomagnesemia Is Associated With Increased Incidence of Postoperative Atrial Fibrillation After Esophageal Resection: A Retrospective Study

Hizuka

Kato

Shiko

et al. 2021

Cureus

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Introduction: Postoperative atrial fibrillation (POAF) is common after surgery for esophageal cancer and may prolong hospitalization and elevate mortality. POAF and hypomagnesemia are linked, but this is based on studies showing an association of POAF with serum total magnesium (tMg). In contrast, the relationship of POAF with ionized magnesium (iMg), which has physiological activity, has not been examined. In this study, the association between hypomagnesemia and POAF was investigated retrospectively to examine iMg as a possible predictive factor for POAF. Methods: The subjects were 151 patients who underwent right transthoracoabdominal subtotal esophagectomy at Saitama Medical Center between January 2011 and December 2020. The incidence of POAF and predictive factors were examined retrospectively. Perioperative predictive factors were subjected to univariate analysis, and items with P<0.1 were then included in multivariate analysis, along with five potential POAF predictors reported in the literature (age, gender, body mass index, hypertension, and diabetes mellitus). P<0.05 was regarded as significant in the multivariate analysis. Results: Of the 151 patients, 34 (23%) developed POAF. In univariate analysis, six factors with P<0.1 (oral statin, dyslipidemia, iMg level after anesthesia induction, maximum and minimum iMg during surgery, and iMg level immediately before admission to ICU) were identified. In multivariate analysis including these and the five literature factors as explanatory variables, iMg immediately before admission to ICU emerged as a predictive factor for POAF (iMg≥0.46 mmol/L, OR 0.32, 95%CI 0.14-0.74, p=0.01) (standard iMg range: 0.48-0.60 mmol/L). Conclusion: The iMg level immediately before admission to ICU may be associated with the development of POAF. A further study is needed to evaluate changes in iMg in the ICU and iMg at the time of onset of POAF.

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Section: Discussionmentioning

confidence: 99%

Ionized Hypomagnesemia Is Associated With Increased Incidence of Postoperative Atrial Fibrillation After Esophageal Resection: A Retrospective Study

Hizuka

Kato

Shiko

et al. 2021

Cureus

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“…These findings are consistent with a previous meta‐analysis by Alghamdi et al A meta‐analysis by Cook et al is the only meta‐analysis that has shown a lack of beneficial effect of Mg in the prevention of POAF. This meta‐analysis was rigorously conducted by including only those RCTs that studied AF as a primary endpoint, included blinding, and had intention‐to‐treat analysis. However, the majority of these RCTs (4/5) did not administer Mg preoperatively to prevent POAF.…”

Section: Use Of Mg In Postoperative Afmentioning

confidence: 99%

Magnesium Adjunctive Therapy in Atrial Arrhythmias

Ganga

Noyes

White

et al. 2013

Pacing Clinical Electrophis

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Magnesium (Mg) is an important intracellular ion with cardiac metabolism and electrophysiologic properties. A large percentage of patients with arrhythmias have an intracellular Mg deficiency, which is out of line with serum Mg concentrations, and this may explain the rationale for Mg's benefits as an atrial antiarrhythmic agent. A current limitation of antiarrhythmic therapy is that the potential for cardiac risk offsets some of the benefits of therapy. Mg enhances the balance of benefits to harms by enhancing atrial antiarrhythmic efficacy and reducing antiarrhythmic proarrhythmia potential as well as providing direct antiarrhythmic efficacy when used as monotherapy in patients undergoing cardiothoracic surgery.

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A prediction model for new-onset atrial fibrillation following coronary artery bypass graft surgery: A multicenter retrospective study

Zhang

Wang

et al. 2023

Heliyon

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Myocardial extraction of intracellular magnesium and atrial fibrillation after coronary surgery

Cited by 7 publications

References 24 publications

Ionized Hypomagnesemia Is Associated With Increased Incidence of Postoperative Atrial Fibrillation After Esophageal Resection: A Retrospective Study

Ionized Hypomagnesemia Is Associated With Increased Incidence of Postoperative Atrial Fibrillation After Esophageal Resection: A Retrospective Study

Magnesium Adjunctive Therapy in Atrial Arrhythmias

A prediction model for new-onset atrial fibrillation following coronary artery bypass graft surgery: A multicenter retrospective study

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