Myocardial Dysfunction in Pediatric Septic Shock

Diastolic dysfunction and mortality in septic patients: a systematic review and meta-analysis

“…A study in the paediatric population found an incidence of DD of 50 % among children with septic shock [31].…”

“…This is not surprising as the E/E 0 ratio is strongly correlated to left atrial pressure (also in patients with septic shock) [33], and raised left atrial pressure may predict poor responsiveness to volume expansion. A TDI method for assessing DD has been also used in the paediatric population by Raj et al [31], but they did not find association between DD and mortality. More studies are desirable before routinely introducing TDI parameters in clinical practice as a tool for evaluating fluid responsiveness, but this method seems interesting for its simplicity and reproducibility.…”

Cardiac biomarkers in children with congenital heart disease

“…[8] Moreover, serum TnI levels were also found to be increased in patients without AMI or HF, and were elevated in 75% of patients who received treatment in the intensive care unit for systemic inflammatory response syndrome and sepsis. [9,10] It has been suggested that systemic inflammatory enzymes, such as tumor necrosis factor alpha (TNF-α), interleukin (IL) 6, and reactive oxygen species, may cause myocardial damage. [11] Moreover, elevated TnI levels are found in 40% of patients with acute pulmonary embolism.…”

The Trend of β₃-Adrenergic Receptor in the Development of Septic Myocardial Depression: A Lipopolysaccharide-Induced Rat Septic Shock Model

“…Unlike that in adults, “cold shock” with low cardiac output and high peripheral vascular resistance is very common in children. Cardiovascular dysfunction occurs in about 70% of children with severe sepsis [3]; also called septic myocardial depression or septic cardiomyopathy, it increases the mortality of septic shock [4, 5]. However, the underlying mechanism of septic myocardial depression remains unclear.…”