Myocardial dysfunction in ankylosing spondylitis.

Gould, Brian A.; Turner, J. Rick; Keeling, D. H.; Hickling, P.; Marshall, Andrew J.

doi:10.1136/ard.51.2.227

Cited by 51 publications

(34 citation statements)

References 12 publications

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“…Cardiac and aortic tissue both show intimal proliferation of small arteries (obliterative endarteritis) and fibrosis, similar to that seen around affected joints [64]. Left ventricular filling abnormalities have been described, perhaps resulting from a mild, diffuse increase in interstitial connective tissue without associated inflammatory changes or amyloid deposits [65,66]. Both cardiac and conduction abnormalities and aortic regurgitation occur in patients with various HLA-B27-related extracardiac disorders, regardless of severity.…”

Section: Human Leukocyte Antigen B27-associated Rheumatic Disordersmentioning

confidence: 96%

Cardiovascular complications of collagen vascular disease

Sander

Giles

2002

Curr Treat Options Cardio Med

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Collagen vascular diseases commonly affect the heart; cardiovascular events are the major cause of mortality in people with these diseases. A striking feature of the cardiac involvement in individuals with systemic lupus erythematosus (SLE) and rheumatoid arthritis is aggressive and accelerated atherosclerosis; women with SLE in the 35- to 44-year-old age group are more than 50 times more likely to suffer myocardial infarction than are matched controls. Traditional risk factors contribute to the accelerated atherosclerosis, but cannot explain the extent of risk. It is possible that the inflammatory process, which is similar to the inflammatory process in atherosclerosis, pays a critical pathophysiologic role. It is critically important to identify the presence of traditional cardiovascular risk factors (eg, tobacco usage, hypertension, hypercholesterolemia, diabetes, homocysteinemia), and to modify these to secondary prevention targets. Cardiac valvular disease is common in individuals with SLE and rheumatoid arthritis; its presence should be anticipated and subacute bacterial endocarditis prophylaxis precautions initiated. Cardiac autonomic neuropathy and conduction disturbances are common in people with heart disease related to systemic sclerosis and human leukocyte antigen B27; these patients should be monitored carefully for evidence of dysrhythmias.

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Section: Human Leukocyte Antigen B27-associated Rheumatic Disordersmentioning

confidence: 96%

Cardiovascular complications of collagen vascular disease

Sander

Giles

2002

Curr Treat Options Cardio Med

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“…Cardiomyopathy was reported in patients with ankylosing spondylitis 31 years ago already [28]. In a series of studies in such patients with cardiomyopathy, but without aortic regurgitation or conduction abnormalities-other known sequelae of HLA-B27-early diastolic dysfunction was found [29,30] with histological examination showing a mild and diffuse increase in interstitial connective tissue [29]. It was shown that the myocardium can develop histopathological abnormalities in the small arteriesan obliterative intimal proliferation-this obliterative arteritis is also found in the tissues adjacent to affected joints, the sinus node artery, the atrioventricular nodal artery and the vasa vasora of the proximal aorta [2].…”

Section: Discussionmentioning

confidence: 99%

HLA-B27 and an Electrocardiographic Peculiarity

Ker¹

2011

J Clinic Experiment Cardiol

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Introduction: An increased cardiovascular mortality has been described in patients with spondyloarthropathies due to HLA-B27. Numerous cardiovascular afflictions are currently known to be associated with HLA-B27. These include aortic root dilation, aortic regurgitation, mitral regurgitation, myocarditis, heart failure, pericarditis, pericardial effusion, atrioventricular conduction block and more recently, the presence of J-waves.Materials and methods: 48 HLA-B27 positive patients (23 men and 25 women) were included in this observational study. A 12-lead electrocardiogram and a signal-averaged electrocardiogram was recorded in every patient in order to detect any possible J-waves and ventricular late potentials respectively.Results: 27 out of these 48 patients demonstrated a visible J-wave in the inferolateral leads. It was revealed that there is a likelihood ratio of 11.386 (p=0.00074) to demonstrate a visible J-wave if the duration of low-amplitude signals is less than 30 ms. Conclusion:HLA-B27 positive patients has a high incidence of inferolateral cardiac J-waves. There is a high probability of demonstrating such a J-wave on the 12-lead electrocardiogram if the duration of ventricular late potentials is less than 30 ms. The possible mechanisms of this electrocardiographic paradox is discussed.

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“…In various studies, it has been shown that diastolic dysfunction and left ventricular hypertrophy were seen in patients with AS. Diastolic dysfunction in patients with AS was determined by echocardiography and histopathologic examination (6,7,26).…”

Section: Discussionmentioning

confidence: 99%