Myocardial disarray at junction of ventricular septum and left and right ventricular free walls in hypertrophic cardiomyopathy

Kuribayashi, Toshiro; Roberts, William C.

doi:10.1016/0002-9149(92)90771-p

Cited by 135 publications

(104 citation statements)

References 28 publications

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“…The myocardial hyperenhancement in HCM did not respect any specific coronary territory and in the majority of HCM subjects was found mostly at the junction between the interventricular septum and right ventricular free wall ( Figure 6). This was previously demonstrated by HCM necropsy studies that showed myocardial disarray and highly accentuated fibrosis in these areas 8,[24][25][26] .…”

Section: Fig 4 -A Patient Example With Hypertrophic Cardiomyopathy supporting

confidence: 66%

Ressonância magnética cardiovascular na cardiomiopatia hipertrófica

Shiozaki¹,

Kim²,

Parga³

et al. 2007

Arq. Bras. Cardiol.

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Section: Fig 4 -A Patient Example With Hypertrophic Cardiomyopathy supporting

confidence: 66%

Ressonância magnética cardiovascular na cardiomiopatia hipertrófica

Shiozaki¹,

Kim²,

Parga³

et al. 2007

Arq. Bras. Cardiol.

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“…Similarly, a positive and significant correlation, r = 0.613 (p = 0.003),was demonstrated between the LV total mass and the LE total mass, also between the groups, with r = 0.725 (p = 0.012) for the obstructive group and r = 0.756 (p = 0.011) for the non-obstructive group. These findings can be related to the presence of the myocardial fascicular disarray associated to numerous tissue "grooves" and destruction of the normal circular architecture in the middle muscular layer of the hypertrophied myocardial regions 17 , allowing the increased deposition of contrast, associated to its slower depuration, as mentioned before. At the sites that present fibrosis and increased extracellular space, there is an increased accumulation of gadolinium-DTPA and the kinetics of its distribution is slower than in the normal myocardium.…”

Section: Discussionmentioning

confidence: 66%

Realce tardio e perfusão miocárdica em cardiomiopatia hipertrófica (comparação entre grupos)

Barbosa¹,

Castro²,

Ávila³

et al. 2009

Arq. Bras. Cardiol.

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SummaryBackground: The magnetic resonance imaging (MRI) is an effective method to study hypertrophic cardiomyopathy (HCM).Objective: To evaluate, using MRI, the parameters of systolic function, perfusion and myocardial viability in patients with HCM, comparing the groups with and without obstruction of the left ventricular outflow tract.Methods: Twenty-one patients with a diagnosis of HCM underwent the assessment of myocardial function, viability and perfusion under stress and at rest through MRI.Results: The ventricular segments most severely impaired by hypertrophy were those of the septal region. The obstructive group presented segmental myocardial thickening distribution similar to the non-obstructive group, but with higher means than the first group. The mean ejection fraction of the patients in the obstructive group was higher than in the non-obstructive group, whereas the means of the end systolic and diastolic volumes were lower in the obstructive group. There was a positive correlation between the ventricular segmental thickening and the late enhancement segmental mass. The stress induction resulted in an increase in the number of segments with perfusion alterations and this alteration was more evident in the obstructive group. Conclusion

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“…Myocardial fibrosis of HCM has been reported to be not transmural but predominant in the midwall layer. 26, 27 There were some limitations to the present study. It was conducted in a single center and the patients were highly selected, indicating that it may not be possible to extrapolate the present findings to the general HCM population.…”

mentioning

confidence: 86%