Myocardial deformation and total atrial conduction time in the prediction of cardiac involvement in patients with pulmonary sarcoidosis

Değirmenci, Hüsnü; Demirelli, Selami; Arif, Ambreen; Ermis, Emrah; Araz, Ömer; Bakırcı, Eftal Murat; Hamur, Hikmet; Büyüklü, Mutlu; Topal, Ergün

doi:10.1111/crj.12307

Cited by 19 publications

(23 citation statements)

References 42 publications

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“…Nevertheless, in our study, strain parameters were not significantly influenced by treatment with immunosuppressant medications. These findings are consistent with those of previous studies that evaluated data for asymptomatic patients with extracardiac sarcoidosis and no definite cardiac involvement [20][21][22][23]. However, in these reports, alterations in regional myocardial mechanics attributable to other noncardiac causes (ie, pulmonary hypertension, valve disease, or concurrent steroid treatment) could not be excluded.…”

Section: Discussionsupporting

confidence: 91%

Diagnostic and predictive value of speckle tracking echocardiography in cardiac sarcoidosis

Stefano

Bruno

Calle

et al. 2020

BMC Cardiovasc Disord

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Background: Sarcoidosis is a systemic granulomatous disease that may affect the myocardium. This study evaluated the diagnostic and prognostic value of 2-dimensional speckle tracking echocardiography in cardiac sarcoidosis (CS). Methods: Eighty-three patients with extracardiac, biopsy-proven sarcoidosis and definite/probable diagnosis of cardiac involvement diagnosed from January 2005 through December 2016 were included. Strain parameters in early stages of CS, in a subgroup of 23 CS patients with left ventricular ejection fraction (LVEF) within normal limits (LVEF> 52% for men: > 54% for women, mean value: 57.3% ± 3.8%) and no wall motion abnormalities was compared with 97 controls (1:4) without cardiac disease. LV and right ventricular (RV) global longitudinal (GLS), circumferential (GCS), and radial (GRS) strain and strain rate (SR) analyses were performed with TomTec software and correlated with cardiac outcomes (including heart failure and arrhythmias). This study was approved by the Mayo Clinic Institutional Review Board, and all patients gave informed written consent to participate. Results: Mean age of CS patients was 53.6 ± 10.8 years, and 34.9% were women. Mean LVEF was 43.2% ± 12.4%; LV GLS, − 12.4% ± 3.7%; LV GCS, − 17.1% ± 6.5%; LV GRS, 29.3% ± 12.8%; and RV wall GLS, 14.6% ± 6.3%. In the 23 patients with early stage CS with normal LVEF and RV systolic function, strain parameters were significantly reduced when compared with controls (respectively: LV GLS, − 15.9% ± 2.5% vs − 18.2% ± 2.7% [P = .001]; RV GLS, − 16.9% ± 4.5% vs − 24.1% ± 4.0% [P < .001]). A LV GLS value of − 16.3% provided 82.2% sensitivity and 81.2% specificity for the diagnosis of CS (AUC 0.91), while a RV value of − 19.9% provided 88.1% sensitivity and 86.7% specificity (AUC 0.93). Hospital admission and heart failure significantly correlated to impaired LV GLS (> − 14%). Conclusion: Reduced strain values in the LV GLS and RV GLS can be used in the diagnostic algorithm in patients with suspicion of cardiac sarcoidosis. These values also correlate with adverse cardiovascular events.

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Section: Discussionsupporting

confidence: 91%

Diagnostic and predictive value of speckle tracking echocardiography in cardiac sarcoidosis

Stefano

Bruno

Calle

et al. 2020

BMC Cardiovasc Disord

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“…These findings are consistent with those of previous studies that evaluated data for asymptomatic patients with extracardiac sarcoidosis and no definite cardiac involvement. [20][21][22][23] However, in these reports, alterations in regional myocardial mechanics attributable to other noncardiac causes (ie, pulmonary hypertension, valve disease, or concurrent steroid treatment) could not be excluded. In addition, 2D-STE was able to detect indirect signs of myocardial damage (both active inflammation or scars and fibrosis) seen on CMR or FDG-PET imaging.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Predictive Value of Speckle Tracking Echocardiography in Cardiac Sarcoidosis

Stefano

Bruno

Calle

et al. 2019

Preprint

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Background: Sarcoidosis is a systemic granulomatous disease that may affect the myocardium. This study evaluated the diagnostic and prognostic value of 2-dimensional speckle tracking echocardiography in cardiac sarcoidosis (CS). Methods: Eighty-three patients with extracardiac, biopsy-proven sarcoidosis and definite/probable diagnosis of cardiac involvement diagnosed from January 2005 through December 2016 were included. In order to analyze the alteration of strain parameters in early stages of CS, a subgroup of 23 CS patients with left ventricular ejection fraction (LVEF) within normal limits (LVEF>52% for men: >54% for women, mean value: 57.3%±3.8%) and no wall motion abnormalities was compared with 97 controls (1:4) without cardiac disease. LV and right ventricular (RV) global longitudinal (GLS), circumferential (GCS), and radial (GRS) strain and strain rate (SR) analyses were performed with TomTec software and correlated with cardiac outcomes (including heart failure and arrhythmias). This study was approved by the Mayo Clinic Institutional Review Board, and all patients gave informed written consent to participate. Results: Mean age of CS patients was 53.6±10.8 years, and 34.9% were women. Mean LVEF was 43.2%±12.4%; LV GLS, -12.4%±3.7%; LV GCS, -17.1%±6.5%; LV GRS, 29.3%±12.8%; and RV wall GLS, 14.6%±6.3%. In the 23 patients with early stage CS with normal LVEF and RV systolic function, strain parameters were significantly reduced when compared with controls (respectively: LV GLS, -15.9%±2.5% vs -18.2%±2.7% [ P =.001]; RV GLS, -16.9%±4.5% vs -24.1%±4.0% [ P <.001]). A LV GLS value of -16.3% provided 82.2% sensitivity and 81.2% specificity for the diagnosis of CS (AUC 0.91), while a RV value of -19.9% provided 88.1% sensitivity and 86.7% specificity (AUC 0.93). Hospital admission and heart failure significantly correlated to impaired LV GLS (> -14%). Conclusion: Reduced strain values in the LV GLS and RV GLS can be used in the diagnostic algorithm in patients with suspicion of cardiac sarcoidosis. These values also correlate with adverse cardiovascular events.

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“…However, concerns about the potential toxicity of nanoparticles have been voiced in the literature, as the interactions at the nano-bio interface may impact the function of biomolecules, cellular components and tissue structures, well beyond the contemplated drug delivery paradigm [49]. Finally, a study performed by Gandhi et al [50] presented a sol-gel device, consisting of GELRITE Gellan polymer loaded with CHX. This device would release the drug only in an acidic inflammatory environment, hence preventing premature peaking of the drug associated with possible side effects.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and potential use of novel sustained release fillers as intracanal medicaments against Enterococcus faecalis biofilm in vitro

et al. 2019

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Background Enterococcus faecalis is a bacterium frequently isolated after failed root canal therapy. This study analyzed the antibacterial and antibiofilm effects in vitro of sustained-release fillers (SRF) containing cetylpyridinium chloride (CPC) against vancomycin resistant E. faecalis . Methods First, the solidification capability was tested by introducing liquid SRF into phosphate buffered saline, followed by 30 s of vortexing. The antimicrobial effects of SRF-CPC against static monospecies biofilms were analyzed with a metabolic assay. Inhibition of biofilm formation was tested by exposing daily refreshed E. faecalis suspensions to SRF-CPC for 9 weeks. To evaluate the effects of SRF-CPC against preformed biofilms, biofilms were grown for 1, 3 and 7 days, and then treated with SRF-CPC for 24 h. Biofilm kill time was tested by applying SRF-CPC to a 3-day-old biofilm and measuring its viability at different time points. All experiments were compared to Placebo SRFs and to untreated control biofilms. Data were analyzed with two-way ANOVA followed by Tukey’s test. Results were considered significant at P < 0.05. Results The liquid SRF solidified within seconds and no structural changes were observed after 30 s of vortexing at maximum speed. SRF-CPC inhibited E. faecalis biofilm formation for 7 weeks and significantly reduced its viability in weeks 8 and 9. Mature biofilms grown for 1, 3 and 7 days were destructed by SRF-CPC in less than 24 h. Fifty percent of a 3-day-old biofilm was destructed in 2 h and complete destruction occurred in less than 12 h. ( P < 0.05 in all cases, compared to SRII-Placebo). Conclusions SRF-CPC’s physical properties and long-lasting anti-biofilm effects make it a promising coadjuvant medication for endodontic therapy. Electronic supplementary material The online version of this article (10.1186/s12903-019-0879-1) contains supplementary material, which is available to authorized users.

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Myocardial deformation and total atrial conduction time in the prediction of cardiac involvement in patients with pulmonary sarcoidosis

Abstract: The identification of left atrial and left ventricular myocardial deformation using speckle tracking echocardiography in patients with PS allows subclinical LV dysfunction and subclinical electrophysiologic changes to be detected earlier.

Cited by 19 publications

References 42 publications

Diagnostic and predictive value of speckle tracking echocardiography in cardiac sarcoidosis

Diagnostic and predictive value of speckle tracking echocardiography in cardiac sarcoidosis

Diagnostic and Predictive Value of Speckle Tracking Echocardiography in Cardiac Sarcoidosis

Efficacy and potential use of novel sustained release fillers as intracanal medicaments against Enterococcus faecalis biofilm in vitro

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