Myocardial contractile dysfunction contributes to the development of heart failure in rats with aortic stenosis

Bregagnollo, Edson Antônio; Zornoff, Leonardo A. M.; Okoshi, Katashi; Sugizaki, Mário Mateus; Mestrinel, Marco Aurélio; Padovani, Carlos Roberto; Cicogna, Antônio Carlos

doi:10.1016/j.ijcard.2006.06.006

Cited by 23 publications

(27 citation statements)

References 28 publications

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“…By the end of the experiment, HF signs were sought, and the presence of tachypnea was considered an exclusion criterion when associated to one of the following signs: oedema, ascites, pleuro-pericardial effusion, thrombus in left atrium (LA) and right ventricular (RV) hypertrophy 14 .…”

Section: Animals and Experimental Protocolmentioning

confidence: 99%

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Remodelamento cardíaco: análise seriada e índices de detecção precoce de disfunção ventricular

Mendes¹,

Campos²,

Damatto³

et al. 2010

Arq. Bras. Cardiol.

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Background: Supravalvar aortic stenosis (SVAS) is used to study overload-induced cardiac remodeling (CR). In this model, neither CR behavior since beginning stage nor the best parameters to identify ventricular dysfunction are clearly stated.Objective: ) Characterizing, early and evolutively, morphological and functional modifications during CR in rats with SVAS and ) identifying the most sensitive index for detecting the moment when the diastolic and systolic dysfunction first appeared in the left ventricle (LV). Methods IntroductionCardiac remodeling (CR) refers to an alteration in gene expression in response to an aggression, resulting in molecular changes, cellular changes and myocardial interstitial alterations, expressed in variations of the heart size, shape and function 1 . This is also a mechanism in adaptation to hemodynamic overload, allowing the heart to keep its functions in view of load increase 2-4 . This is deemed as a risk factor for development of ventricular dysfunction and heart failure (HF) 5 .Several experimental models have been proposed for the study of CR due to pressure overload, such as supravalvar aortic stenosis (SVAS) in rats [6][7][8] . When young animals are subject to aortic constriction, pressure overload is low at the beginning, being increased proportionally with their growth. SVAS advantages are: gradual development of CR, associated in short term to the improvement of systolic function; absence of severe lesions in myocardial anatomy; and low maintenance cost 9 . Around the 20 th week of SVAS, deterioration of systolic performance and HF [10][11][12][13] begin. This model is partially similar to SVAS in men 11 .Experiments in our lab with rats with SVAS assessed morphological and functional cardiac aspects, by means of echocardiogram (ECHO), in different periods of CR, finding out supranormal systolic function in 6 th or 8 th week 4,9,12 , diastolic dysfunction as of the 12nd week 9 and deterioration of systolic performance in the 21 st week. This last group of animals also had signs of heart failure 9 . Some authors, using hemodynamic evaluation, verified increase in left ventricular end-diastolic pressure after the 6 th week -in contrast, evaluation of diastolic function by means of ECHO has been found inaltered 13 . Litwin et al 8 assessed rats with SVAS by means of ECHO during 6 th , 12 th and 18 th weeks, and observed diastolic dysfunction as of the 6 th week and deterioration of systolic performance in the 18 th week.Analysis of mentioned studies has shows controversial results and absence of evaluation in an earlier post-induction of SVAS. The study aimed at characterizing, early and evolutively, Original ArticleArq Bras Cardiol 2010; 94(1) : 59-66

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Section: Animals and Experimental Protocolmentioning

confidence: 99%

“…Heart's function and structure were analyzed by means of ECHO according to methodology used in our lab 4,9,10,14 . Animals were anesthetized with ketamine chloride (50 mg/kg) and xylazine chloride (1 mg/kg), intraperitoneal.…”

Section: Echocardiographic Assessmentmentioning

confidence: 99%

Remodelamento cardíaco: análise seriada e índices de detecção precoce de disfunção ventricular

Mendes¹,

Campos²,

Damatto³

et al. 2010

Arq. Bras. Cardiol.

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“…Aortic stenosis (AS) was induced according to the method previously described in our laboratory [34,35]. The animals were submitted to median thoracotomy and trichotomy after anesthesia with ketamine hydrochloride (50 mg/kg intraperitoneally) and xylazine hydrochloride (10 mg/kg intraperitoneally).…”

Section: Aortic Stenosis Surgery and Heart Failure Inductionmentioning

confidence: 99%

Growth hormone and heart failure: Oxidative stress and energetic metabolism in rats

Seiva

Ebaid

Castro

et al. 2008

Growth Hormone & IGF Research

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“…Este procedimento descartou áreas seccionais do músculo papilar acima de 1,7 mm 2 . O descarte pela área seccional do músculo papilar é freqüentemente usado na literatura, (207,208) pois possibilita no estudo a comparação apenas de animais com áreas seccionais semelhantes. A utilização de músculos com área diferentes pode acarretar erros de interpretação, pois há uma relação inversa entre a área seccional e o desenvolvimento de força.…”

Section: 1-modelo Experimental De Obesidadeunclassified

Influência do tempo de exposição à obesidade sobre a função cardíaca de ratos

Leopoldo¹

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Myocardial contractile dysfunction contributes to the development of heart failure in rats with aortic stenosis

Cited by 23 publications

References 28 publications

Remodelamento cardíaco: análise seriada e índices de detecção precoce de disfunção ventricular

Remodelamento cardíaco: análise seriada e índices de detecção precoce de disfunção ventricular

Growth hormone and heart failure: Oxidative stress and energetic metabolism in rats

Influência do tempo de exposição à obesidade sobre a função cardíaca de ratos

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