Myocardial Cell Abnormalities in Heart Failure: Experience from Studies on Single Myocytes

Davies, C. S. L.; Brown, Lesley A.; Monte, Federica del; Poole‐Wilson, Philip A.; Harding, Siân E.

doi:10.1007/978-1-4613-1237-6_16

Cited by 1 publication

(1 citation statement)

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“…Abnormalities in the myocardial cell functions are the primary pathophysiologic basis of heart failure. 83 However, there is a growing body of literature suggesting that damaged microvascular health is the root cause of myocardial dysfunction. [84][85][86] Similar effects have also been observed in patients on dialysis.…”

Section: Organ System 3-unexplained Heart Failurementioning

confidence: 99%

Understanding clinical complexity in organ and organizational systems: Challenges local and global

Samitinjay,

Vaishnavi,

Gongireddy

et al. 2023

Evaluation Clinical Practice

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IntroductionComplexity in healthcare systems has been arbitrarily defined as tasks or systems ranging from complicated to intractable, with a general view of these not being ‘simple’. Complexity in healthcare systems in first‐world countries has been well elucidated, however, data from third‐world countries is still scant.Materials and MethodsWe present four cases each from three different organ systems—chronic kidney disease, alcohol use disorder, and heart failure—in the backdrop of our healthcare organization. We present our analysis of the complexities faced clinically and, in our local healthcare system which led to these events.ResultsAnalysis of these cases showed that patients with chronic kidney disease had vertebral–spinal pathologies due to poor infection control measures during haemodialysis. All these patients were young with a long history of secondary hypertension. In patients with alcohol use disorder, a common theme of how government regulations and peer pressure promote alcohol use is analysed. In the four patients with unexplained heart failure, vascular health is viewed as a fractal dimension and the various factors affecting vascular health are elaborated.ConclusionComplexities exist clinically in making a diagnosis, and organizationally, in the variables and nodes dictating patient outcomes. Clinical complexities cannot be simplified but have to be navigated in an optimized way to improve clinical outcomes.

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Section: Organ System 3-unexplained Heart Failurementioning

confidence: 99%