Myocardial blood flow distribution in patients with ischemic heart disease or dilated cardiomyopathy undergoing heart transplantation.

Parodi, Oberdan; Maria, Renata De; Oltrona, Luigi; Testa, Roberto; Sambuceti, Gianmario; Roghi, Alberto; Merli, M. Giovanna; Belingheri, L; Accinni, R.; Spinelli, Francesca Romana

doi:10.1161/01.cir.88.2.509

Cited by 124 publications

(69 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has also been hypothesized that increased myocardial wall stress leads to decreased subendocardial perfusion, even in the absence of CAD, resulting in a decline in systolic function. 10,22,23 Additional factors, including activation of the renin-angiotensin system, sympathetic nervous system, and inflammatory cytokine system, have been implicated in provoking myocyte injury and cell death in HF. 10,24 A study of patients with acute cardiogenic pulmonary edema found a correlation between serum cTnI levels and markers of sympathetic nervous system activation.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Troponin I Is Associated With Impaired Hemodynamics, Progressive Left Ventricular Dysfunction, and Increased Mortality Rates in Advanced Heart Failure

et al. 2003

View full text Add to dashboard Cite

Background-Cardiac troponin I (cTnI), a sensitive and specific marker of myocardial cell injury, is useful in diagnosing and assessing prognosis in acute coronary syndromes. Small studies report that cTnI is elevated in severe heart failure (HF) and may predict adverse outcomes. Methods and Results-The present study evaluated 238 patients with advanced HF referred for cardiac transplantation evaluation who had cTnI assay drawn at the time of initial presentation. Patients with acute myocardial infarction or myocarditis were excluded from analysis. cTnI was detectable (cTnI Ն0.04 ng/mL) in serum of 117 patients (49.1%).Patients with detectable cTnI levels had significantly higher B-type natriuretic peptide (BNP) levels (PϽ0.001) and more impaired hemodynamic profiles, including higher pulmonary wedge pressures (Pϭ0.002) and lower cardiac indexes (PϽ0.0001). A significant correlation was found between detectable cTnI and progressive decline in ejection fraction over time. Furthermore, detectable cTnI was associated with increased mortality risk (RR, 2.05; 95% CI, 1.22 to 3.43). After adjustment for other factors associated with adverse prognosis including age, sex, ejection fraction, and coronary artery disease, cTnI remained a significant predictor of death. cTnI used in conjunction with BNP further improved prognostic value. Conclusions-cTnI is associated with impaired hemodynamics, elevated BNP levels, and progressive left ventricular dysfunction in patients with HF. cTnI may be a novel, useful tool in identifying patients with HF who are at increased risk for progressive ventricular dysfunction and death.

show abstract

Section: Discussionmentioning

confidence: 99%

Cardiac Troponin I Is Associated With Impaired Hemodynamics, Progressive Left Ventricular Dysfunction, and Increased Mortality Rates in Advanced Heart Failure

et al. 2003

View full text Add to dashboard Cite

show abstract

“…In heart failure with pressure overload, compensated concentric hypertrophy in the left ventricular progresses due to the increase in pressure after overload. As a result, then the interstitial fibrosis changes the myocardial structure [21,26,27]. In addition, the changes in myocardial structure inhibit myocardial diastolic and systolic function, resulting in cardiac dysfunction [26,27].…”

mentioning

confidence: 99%

Effect of Long-term Administration of a Prostacyclin Analogue (Beraprost Sodium) on Myocardial Fibrosis in Dahl Rats

Kaneshige

Saida

Tanaka

et al. 2007

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. Beraprost sodium (BPS) is an orally active prostacyclin analogue. The effects of BPS on the heart, including coronary circulation improvement, myocardial and vascular protection and anti-fibrosis effect on myocardium interstitium, have previously been demonstrated. However, the effects of BPS on hemodynamics, cardiac function and myocardial contractility in patients in the hypertrophic phase have not been clarified. Therefore, in the present study, the effects of BPS under long-term administration were investigated using the hypertension model of salt-sensitive Dahl rats. Six-week-old Dahl rats were divided into three groups, an 8% high salt diet group treated with BPS (BPS group), an untreated 8% high salt diet group (HHF group) and an untreated 0.3% low salt diet group (Control group), and observations were conducted until 17 weeks of age. In the BPS and HHF groups, the survival rates after 11 weeks of high salt diet intake were 87.5% and 47.1%, respectively (p<0.05). At 17 weeks of age, the atrial systolic peak velocity/early diastolic peak velocity and heart weight index of the BPS group decreased significantly compared with the HHF group (p<0.05). The HHF group exhibited significantly more severe myocardial fibrosis mainly in the endocardial layer of the left and right ventricles compared with the BPS and Control groups (p<0.05). In the present study, long-term BPS administration preserved diastolic function and prevented myocardial interstitial fibrosis in the non-compensatory phase. The results of the present study suggest that BPS is effective for treatment of hypertensive cardiac hypertrophy. KEY WORDS: beraprost sodium, Dahl rat, echocardiography, hypertension, myocardial fibrosis.J. Vet. Med. Sci. 69(12): 1271-1276, 2007 Prostacyclin is found in all body tissues and body fluids and is the major metabolite of arachidonic acid in the vasculature [6,16]. It is a potent vasodilator that affects both systemic and pulmonary circulations. Prostacyclin also prevents vascular smooth muscle proliferation and inhibits platelet adhesion and aggregation [6]. These features make it a very attractive substance for treatment of various cardiovascular diseases [6,15,16,20]. Beraprost sodium (BPS) is an orally active prostacyclin analogue that was discovered and developed by Toray Industries in Japan [1,16]. In human medicine, long-term administration of BPS has been approved as a treatment for chronic arterial occlusion [16] and primary pulmonary hypertension [2,8,16]. In addition, oral administration of BPS can be used as a therapeutic treatment for secondary precapillary pulmonary hypertension [17], cerebral infarction [9,13], glomerulonephritis [12,28], diabetic nephropathy [29] and atherosclerotic vascular damage in coronary artery disease [23]. In heart failure with pressure overload, compensated concentric hypertrophy in the left ventricular progresses due to the increase in pressure after overload. As a result, then the interstitial fibrosis changes the myocardial structure [21,26,27]. In addition, th...

show abstract

“…Myocardial fibrosis may occur in patients with IDCM as well as in patients with IHF; however, according to our analysis, the myocardial perfusion defects at rest were more expressed in patients with IHF. Other mechanisms, besides myocardial hemodynamic and structural derangements, seems to be important in determining impairment of myocardial blood flow at rest in advanced IDCM (12). The differentiation of HF related to IDCM and IHD using gadolinium-enhanced cardiovascular magnetic resonance imaging has shown that coronary angiography may be flawed in identifying the myocardial substrate for HF as significant CA disease may exist without myocardial infarction, and "normal" CA may be in the presence of myocardial damage coherent with the pattern of subendocardial to transmural enhancement (6).…”

Section: Discussionmentioning

confidence: 99%

“…On the basis of coronary angiography findings, all the patients were divided into two study groups: Group 1 comprised 26 patients with normal CA or CA with insignificant (<50%) stenosis, and Group 2 consisted of 17 patients with 50-75% stenosis of three main CA branches or 75-95% stenosis or occlusions of two main CA branches (11,12). According to our previously described methodology (13,14), all the patients underwent a myocardial gated single photon emission computed tomography (SPECT) with 99m Tc-MIBI examination at rest.…”

Section: Methodsmentioning

confidence: 99%

The value of 99mTc-MIBI myocardial perfusion imaging in differentiation of heart failure conditioned by global left ventricular systolic impairment

Ragaišytė¹,

Kavoliūnienė²,

Vaicekavičius³

et al. 2009

Medicina

View full text Add to dashboard Cite

show abstract

Myocardial blood flow distribution in patients with ischemic heart disease or dilated cardiomyopathy undergoing heart transplantation.

Cited by 124 publications

References 72 publications

Cardiac Troponin I Is Associated With Impaired Hemodynamics, Progressive Left Ventricular Dysfunction, and Increased Mortality Rates in Advanced Heart Failure

Cardiac Troponin I Is Associated With Impaired Hemodynamics, Progressive Left Ventricular Dysfunction, and Increased Mortality Rates in Advanced Heart Failure

Effect of Long-term Administration of a Prostacyclin Analogue (Beraprost Sodium) on Myocardial Fibrosis in Dahl Rats

The value of 99mTc-MIBI myocardial perfusion imaging in differentiation of heart failure conditioned by global left ventricular systolic impairment

Contact Info

Product

Resources

About