1969
DOI: 10.1172/jci106131
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Myocardial adenyl cyclase: activation by thyroid hormones and evidence for two adenyl cyclase systems

Abstract: ABS TR A CT The mechanism responsible for the hyperdynamic circulatory state in hyperthyroidism has not been defined. Although certain cardiac manifestations resemble those caused by excessive adrenergic stimulation, recent evidence suggests that thyroid hormone exerts an effect on the heart that is independent of the adrenergic system. Since the inotropic and chronotropic effects of norepinephrine appear to be mediated by activation of adenyl cyclase, the possibility that thyroxine and triiodothyronine are al… Show more

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Cited by 161 publications
(35 citation statements)
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“…Evidence for such a hypothesis is provided by several observations. First, it has been proposed that thyroid hormone is capable of activating adenyl cyclase in vitro (10), although the concentrations were pharmacologic. In addition, 38-adrenergic responsiveness in hypothyroid rats is reduced (11), and phosphodiesterase activity correlates inversely with thyroid hormonal status (12).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Evidence for such a hypothesis is provided by several observations. First, it has been proposed that thyroid hormone is capable of activating adenyl cyclase in vitro (10), although the concentrations were pharmacologic. In addition, 38-adrenergic responsiveness in hypothyroid rats is reduced (11), and phosphodiesterase activity correlates inversely with thyroid hormonal status (12).…”
Section: Discussionmentioning
confidence: 99%
“…Several studies suggest that thyroid hormones may also affect cell functions by increasing the intracellular concentration of cAMP (10)(11)(12). The observation that certain clinical manifestations of hyperthy-roidism may result from enhanced ,3-adrenergic responsiveness (13) is consistent with the hypothesis that thyroid hormones interact with receptors having , 8-adrenergic properties. This study examines the influence of thyroid hormones on in vitro erythropoiesis as well as the interactions of these hormones with catecholamine receptors.…”
Section: Introductionmentioning
confidence: 99%
“…41, 43, 53). Thyroid hormones also enhance concentrations of cyclic A M P in target tissues through stimulation of adenylate cyclase (37). Lung tissue studies of cyclic A M P metabolism have to date focused on responses to catecholamines, histamine, prostaglandin E , , and aminophylline.…”
mentioning
confidence: 99%
“…This finding was not significant and clearly more studies with complete doseresponse relations are needed t o clarify these observations. These findings do, however, lend further support t o the hypothesis that perhaps these two classes of hormones activate adenylate cyclase via different receptors (12,14,15,20,21). In preliminary studies with human fetal cardiac tissues stimulation of adenylate cyclase by glucagon and catecholamines was demonstrated a t 12-13 weeks of gestation' (3,19).…”
Section: Discussionmentioning
confidence: 55%
“…Tissues were normally obtained within 10 Receptor activation of myocardial adenylate cyclase by min after disrupti~n of the fetoplacental circulation, placed in hormones (catecholamines, histamine, and glucagon) with cold glycylglycine buffer (2 mM + 1 mM MgS04 + 0.2 mM concomitant production of adenosine 3',5'-monophosphate EGTA, pH 7.4), and returned to the laboratory: Enzymatic (CAMP) has been linked directly to glycogenolysis and investigations were conducted within 1 hr after obtaining the indirectly to positive chronotropic and inotropic effects (1 2, tissue. Extraneous connective tissue was dissected free and the 14,15,20,21). Robison et al (23) postulated that the hearts were blotted and rapidly weighed.…”
mentioning
confidence: 99%