Myocardial Adaptation to Long-Term Action of Substances Associated with Decreased Intensity of Cardiac Function

Veksler, Vladimir; Levitskaya, E. L.; Khatkevich, A. N.; Orekhova, I V; Khuchua, Zaza; Kapel'ko, V. I.

doi:10.1006/bmmb.1994.1051

Cited by 4 publications

(1 citation statement)

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“…Так, длительное (6-8 нед) введение крысам верапамила или пропранолола, ограничивающих поступление Ca 2+ в кардиомиоциты, сопровождалось повышением максимальной насосной функции изолированного сердца. Такое явление, обнаруженное впервые и названное суперкомпенсацией [24], обусловлено увеличением активности Ca 2+ , Mg 2+ -АТФазы миофибрилл и чувствительности миофибрилл к Ca 2+ . Поэтому, когда сердца с устойчиво сниженным содержанием Ca 2+ в кардиомиоцитах были поставлены в условия нормального, но повышенного (для них) уровня внеклеточного Ca 2+ , они реагировали на это более сильными сокращениями по сравнению с сердцами в контрольной группе.…”

Section: доксорубициновая кардиомиопатияunclassified

Compensatory mechanisms of cardiac function at acute and chronic development of the cardiomyopathy

Kapelko¹

2019

Kardio. vestn.

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Насосная функция сердца в организме приспособлена для удовлетворения потребности органов и тканей в питательных веществах и кислороде. При этом функция кардиомиоцитов определяется главным образом величиной нагрузки, зависящей от артериального сопротивле-ния. Эту нагрузку часто называют «постнагрузкой» (термин заимствован из англоязычной литературыafterload). При изменении нагрузки, чаще всего связанной с физической работой, минутный объем крови и, соответственно, деятельность сердца приспосабливаются к изменившемуся запросу мышц и органов на кислород и суб

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Section: доксорубициновая кардиомиопатияunclassified

Compensatory mechanisms of cardiac function at acute and chronic development of the cardiomyopathy

Kapelko¹

2019

Kardio. vestn.

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Untitled

Zoll

Ventura‐Clapier

Serrurier

et al. 2001

Journal of Muscle Research and Cell Motility

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Although thyroid hormones induce a well known decrease in muscle oxidative capacity, nothing is known concerning their effects on mitochondrial function and regulation in situ. Similarly, the influence of regeneration process is not completely understood. We investigated the effects of hypothyroidism on mitochondrial function in fast gastrocnemius (GS) and slow soleus (SOL) muscles either intact or having undergone a cycle of degeneration/regeneration (Rg SOL) following a local injection of myotoxin. Thyroid hormone deficiency was induced by thyroidectomy and propylthiouracyl via drinking water. Respiration was measured in muscle fibres permeabilised by saponin in order to assess the oxidative capacity of the muscles and the regulation of mitochondria in situ. Oxidative capacities were 8.9 in SOL, 8.5 in Rg SOL and 5.9 micromol O2/min/g dry weight in GS and decreased by 52, 42 and 39% respectively (P < 0.001) in hypothyroid rats. Moreover, the Km of mitochondrial respiration for the phosphate acceptor ADP exhibited a two-fold decrease in Rg SOL and intact SOL by hypothyroidism (P < 0.01), while mitochondrial creatine kinase activity and sensitivity of mitochondrial respiration to creatine were not altered. The results of this study demonstrate that hypothyroidism markedly altered the sensitivity of mitochondrial respiration to ADP but not to creatine in SOL muscles, suggesting that mitochondrial regulation could be partially controlled by thyroid hormones. On the other hand, mitochondrial function completely recovered following regeneration/degeneration, suggesting that thyroid hormones are not involved in the regeneration process per se.

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Effects of Prolonged Caffeine Consumption on Cardiac Contractile Function in Rats

Kapel'ko

Лакомкин²,

Студнева³

et al. 2000

Journal of Cardiovascular Pharmacology

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The purpose of the study was to explore effects of prolonged caffeine administration on the contractile function and myocardial energy metabolites of the isolated rat heart. Caffeine treatment for 1 week (10 mg/kg, i.p., twice a day) was followed by unchanged pump function of the isolated heart, but reduced maximal left ventricular (LV) systolic pressure by 14% (p < 0.05). Caffeine consumption during 8-9 weeks (0.1% water solution) was also followed by unchanged maximal pump function but increased maximal double product (LV developed pressure multiplied by heart rate) by 23% (p < 0.05). The hearts of caffeine-consumed rats also maintained a higher level of the pump function at a high rate of atrial electrostimulation. The myocardial content of adenosine triphosphate (ATP), creatine phosphate, as well as creatine was slightly but insignificantly increased after caffeine consumption. Results show that in the course of prolonged caffeine treatment, the maximal myocardial contractile function first decreases and then increases, showing adaptation of the heart.

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Myocardial Adaptation to Long-Term Action of Substances Associated with Decreased Intensity of Cardiac Function

Cited by 4 publications

References 0 publications

Compensatory mechanisms of cardiac function at acute and chronic development of the cardiomyopathy

Compensatory mechanisms of cardiac function at acute and chronic development of the cardiomyopathy

Untitled

Effects of Prolonged Caffeine Consumption on Cardiac Contractile Function in Rats

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