Myo-inositol in the reproductive tract of the female rat

Lewin, L.; Yannai, Y.; Мелмед, Шломо; Weiss, Mordechai

doi:10.1016/0020-711x(82)90154-9

Cited by 19 publications

(8 citation statements)

References 7 publications

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“…An important additional consideration in any potential novel periconceptional preventive therapy for NTDs is the requirement for safety in the fetus and pregnant mother. The inositol concentration is higher in reproductive organs than in blood, and concentration in the ovaries is under hormonal control (Lewin et al, ). Several clinical trials in women with polycystic ovary syndrome have suggested a beneficial effect of inositol ( myo‐ or chiro‐ ) supplements in improving ovarian function, hormone status and menstrual activity, with no reported side effects at typical doses of 2 to 4 g daily (Table ; Nestler et al, ; Gerli et al, ; Genazzani et al, ; Costantino et al, ; reviewed by Dinicola et al, ).…”

Section: Introductionmentioning

confidence: 99%

Inositol, neural tube closure and the prevention of neural tube defects

Greene

Leung

Copp

2017

Birth Defects Research

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Susceptibility to neural tube defects (NTDs), such as anencephaly and spina bifida is influenced by genetic and environmental factors including maternal nutrition. Maternal periconceptional supplementation with folic acid significantly reduces the risk of an NTD‐affected pregnancy, but does not prevent all NTDs, and “folic acid non‐responsive” NTDs continue to occur. Similarly, among mouse models of NTDs, some are responsive to folic acid but others are not.Among nutritional factors, inositol deficiency causes cranial NTDs in mice while supplemental inositol prevents spinal and cranial NTDs in the curly tail (Grhl3 hypomorph) mouse, rodent models of hyperglycemia or induced diabetes, and in a folate‐deficiency induced NTD model. NTDs also occur in mice lacking expression of certain inositol kinases. Inositol‐containing phospholipids (phosphoinositides) and soluble inositol phosphates mediate a range of functions, including intracellular signaling, interaction with cytoskeletal proteins, and regulation of membrane identity in trafficking and cell division. Myo‐inositol has been trialed in humans for a range of conditions and appears safe for use in human pregnancy. In pilot studies in Italy and the United Kingdom, women took inositol together with folic acid preconceptionally, after one or more previous NTD‐affected pregnancies. In nonrandomized cohorts and a randomized double‐blind study in the United Kingdom, no recurrent NTDs were observed among 52 pregnancies reported to date.Larger‐scale fully powered trials are needed to determine whether supplementation with inositol and folic acid would more effectively prevent NTDs than folic acid alone. Birth Defects Research 109:68–80, 2017. © 2016 The Authors Birth Defects Research Published by Wiley Periodicals, Inc.

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Section: Introductionmentioning

confidence: 99%

Inositol, neural tube closure and the prevention of neural tube defects

Greene

Leung

Copp

2017

Birth Defects Research

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“…Rat studies reveal that the MI concentration of the uterus and ovaries are under hormonal control. The INS concentration of female reproductive organs is much higher than in blood serum owing to their ability to concentrate MI from the blood stream . Interestingly, the INS concentration in the uterine fluid was much lower than in seminal fluid of the rat; it means that the surrounding MI concentration for the sperm is lowered when entering the uterus.…”

Section: Biological Function Of Inositol and Its Derivatives In Oocytmentioning

confidence: 97%

“…The INS concentration of female reproductive organs is much higher than in blood serum owing to their ability to concentrate MI from the blood stream. 19 Interestingly, the INS concentration in the uterine fluid was much lower than in seminal fluid of the rat; it means that the surrounding MI concentration for the sperm is lowered when entering the uterus. These high MI concentrations in the male and female reproductive tracts suggest that inositol concentration in physiological fluids may significantly influence fertility.…”

Section: Biological Function Of Inositol and Its Derivatives In Oocytmentioning

confidence: 99%

The rationale of the myo-inositol and D-chiro-inositol combined treatment for polycystic ovary syndrome

Dinicola

Chiu

Unfer³

et al. 2014

The Journal of Clinical Pharmacology

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PCOS is one of the most common endocrine disorders affecting women and it is characterized by a combination of hyper-androgenism, chronic anovulation, and insulin resistance. While a significant progress has recently been made in the diagnosis for PCOS, the optimal infertility treatment remains to be determined. Two inositol isomers, myo-inositol (MI) and D-chiro-inositol (DCI) have been proven to be effective in PCOS treatment, by improving insulin resistance, serum androgen levels and many features of the metabolic syndrome. However, DCI alone, mostly when it is administered at high dosage, negatively affects oocyte quality, whereas the association MI/DCI, in a combination reproducing the plasma physiological ratio (40:1), represents a promising alternative in achieving better clinical results, by counteracting PCOS at both systemic and ovary level.

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“…Intracellular inositol concentrations are therefore dependent on the expression and activity of transporters. The high levels of inositol in the brain and the female reproductive organs are thought to be due to high inositol import, rather than high local inositol synthesis (Thomas, Mills, and Potter 2016;Berry et al 1999;Lewin et al 1982;Di Daniel et al 2009;Bourgeois, Coady, and Lapointe 2005;Frej, Otto, and Williams 2017). Sodium/ Myo-Inositol Transporters (SMIT) are expressed in multiple tissues among Animalia (Zerbino et al 2018;Schneider 2015), while proton (H þ )/Myo-Inositol symporters (HMIT) are found in all living organisms and are closely related to the GLUT family of sugar transporters (Schneider 2015;Mueckler and Thorens 2013).…”

Section: Inositol Transport Proteinsmentioning

confidence: 99%