Myo-inositol in the protection from cadmium-induced toxicity in mice kidney: An emerging nutraceutical challenge

Pallio, Giovanni; Micali, Antonio; Benvenga, Salvatore; Antonelli, Alessandro; Marini, Herbert; Puzzolo, Domenico; Macaione, Vincenzo; Trichilo, Vincenzo; Santoro, Giuseppe; Irrera, Natasha; Squadrito, Francesco; Altavilla, Domenica; Minutoli, Letteria

doi:10.1016/j.fct.2019.110675

Cited by 48 publications

(34 citation statements)

References 55 publications

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“…Quercetin significantly increased serum thyroid hormones in rats treated with CdCl2, even if levels were significantly lower compared to unchallenged rats [37]. In mice, a 14-day treatment with CdCl 2 (2 mg/kg/day) plus MI (360 mg/kg/day) protected the testis [39] and the kidney [40] from the damage induced by CdCl 2 . The Cd-induced testicular damage consisted of smaller tubules, the discontinuity of the seminiferous epithelium, the detachment of spermatogonia from the basal membrane, and reduced claudin-11 immunoreactivity [39].…”

Section: Introductionmentioning

confidence: 92%

“…Beneficial effects against Cd-induced damage of the thyroid or other organs were also described for other naturally occurring molecules that, like Se, are used as nutraceuticals. These molecules are quercetin [37] and myo-inositol (MI) [38][39][40]. Quercetin significantly increased serum thyroid hormones in rats treated with CdCl2, even if levels were significantly lower compared to unchallenged rats [37].…”

Section: Introductionmentioning

confidence: 99%

“…The Cd-induced testicular damage consisted of smaller tubules, the discontinuity of the seminiferous epithelium, the detachment of spermatogonia from the basal membrane, and reduced claudin-11 immunoreactivity [39]. The Cd-induced renal damage consisted of alterations in glomerular and tubular morphology [40]. Concerning the testis, experiments were also conducted with Se alone and with a combination MI plus Se-L-methionine [39], with such a combination having the greatest protective effects on the seminiferous tubules, and in particular on the blood-testis barrier.…”

Section: Introductionmentioning

confidence: 99%

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Protective Effects of Myo-Inositol and Selenium on Cadmium-Induced Thyroid Toxicity in Mice

et al. 2020

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Cadmium (Cd) damages the thyroid gland. We evaluated the effects of myo-inositol (MI), seleno-L-methionine (Se) or their combination on the thyroids of mice simultaneously administered with Cd chloride (CdCl2). Eighty-four male mice were divided into 12 groups (seven mice each). Six groups (controls) were treated with 0.9% NaCl (vehicle), Se (0.2 mg/kg/day), Se (0.4 mg/kg/day), MI (360 mg/kg/day), MI+Se (0.2 mg/kg) and MI+Se (0.4 mg/kg). The other six groups were treated with CdCl2 (2 mg/kg), CdCl2+MI, CdCl2+Se (0.2 mg/kg), CdCl2+Se (0.4 mg/kg), CdCl2+MI+Se (0.2 mg/kg) and CdCl2+MI+Se (0.4 mg/kg). An additional group of CdCl2-challenged animals (n = 7) was treated with resveratrol (20 mg/kg), an effective and potent antioxidant. All treatments lasted 14 days. After sacrifice, the thyroids were evaluated histologically and immunohistochemically. CdCl2 reduced the follicular area, increased the epithelial height, stroma, and cells expressing monocyte chemoattractant protein-1 (MCP-1) and C-X-C motif chemokine 10 (CXCL10). CdCl2+Se at 0.2/0.4 mg/kg insignificantly reversed the follicular and stromal structure, and significantly decreased the number of MCP-1 and CXCL10-positive cells. CdCl2+MI significantly reversed the thyroid structure and further decreased the number of MCP-1 and CXCL10-positive cells. CdCl2+MI+Se, at both doses, brought all indices to those of CdCl2-untreated mice. MI, particularly in association with Se, defends mice from Cd-induced damage. The efficacy of this combination was greater than that of resveratrol, at least when using the follicular structure as a read-out for a comparison. We suggest that the use of these nutraceuticals, more specifically the combination of MI plus SE, can protect the thyroid of Cd-exposed subjects.

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Protective Effects of Myo-Inositol and Selenium on Cadmium-Induced Thyroid Toxicity in Mice

et al. 2020

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“…Mice exposed to cadmium were simultaneously given myoIns either alone on combination with selenium via oral routes. After 14 days, the myoIns combined with selenium group showed better markers and structural integrity than untreated mice in various organs, such as the kidneys [109], testis [110], and thyroid [111], suggesting a protective effect from oxidative stress and, thereby, a role for these compounds as nutraceuticals.…”

Section: Other Health-beneficial Effectsmentioning

confidence: 95%

“…Interestingly, myoIns either alone or in combination with selenium can have beneficial effects in mice exposed to cadmium [109][110][111]. This heavy metal can be found in cigarette smoke and phosphate fertilizers, thereby possibly contaminating the environment and food sources.…”

Section: Other Health-beneficial Effectsmentioning

confidence: 99%

Role of Inositols and Inositol Phosphates in Energy Metabolism

et al. 2020

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Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects. Although their roles in cancer treatment and prevention have been extensively reported, interestingly, they may also have distinctive properties in energy metabolism and metabolic disorders. We review inositols and inositol phosphate metabolism in mammalian cells to establish their biological activities and highlight their potential roles in energy metabolism. These molecules are known to decrease insulin resistance, increase insulin sensitivity, and have diverse properties with importance from cell signaling to metabolism. Evidence showed that inositol phosphates might enhance the browning of white adipocytes and directly improve insulin sensitivity through adipocytes. In addition, inositol pyrophosphates containing high-energy phosphate bonds are considered in increasing cellular energetics. Despite all recent advances, many aspects of the bioactivity of inositol phosphates are still not clear, especially their effects on insulin resistance and alteration of metabolism, so more research is needed.

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Pectin with various degrees of esterification differentially alters gut microbiota and metabolome of healthy adults

Huang

Fang

Fan

et al. 2022

eFood

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Pectin with various degrees of esterification (DE) leads to different food processing directions and has the distinct potential for modulating human health. Investigations of pectin-gut microbiota interactions may contribute towards better understanding of the structure-function mechanism. In this study, in vitro batch fermentation (artificial colon model) was used to illustrate the differential impacts of pectin with different DE on the gut microbiota and metabolome of healthy adults. The results indicated that low-esterified pectin L13 showed better-sustained abilities in terms of the diversity of microbiota and promoted the abundance of Clostridiaceae and Lachnospiraceae at family levels, and Bacteroides and Lachnospira at genus levels. High-esterified pectin H121 induced less Enterococcus and Clostridium. Data from untargeted metabolomics revealed the alterations of intracellular metabolites including fatty acids, amino acids, and organic molecules by various types of pectins. Inositol was the unique intracellular metabolite that was significantly upregulated by low-esterified pectin L13. All types of pectins could increase the level of acetic acid, but butyric acid was only enriched by pectin L13.

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Myo-inositol in the protection from cadmium-induced toxicity in mice kidney: An emerging nutraceutical challenge

Cited by 48 publications

References 55 publications

Protective Effects of Myo-Inositol and Selenium on Cadmium-Induced Thyroid Toxicity in Mice

Protective Effects of Myo-Inositol and Selenium on Cadmium-Induced Thyroid Toxicity in Mice

Role of Inositols and Inositol Phosphates in Energy Metabolism

Pectin with various degrees of esterification differentially alters gut microbiota and metabolome of healthy adults

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