Myo-inositol, Glutamate, and Glutamine in the Prefrontal Cortex, Hippocampus, and Amygdala in Major Depression

Shirayama, Yukihiko; Takahashi, Michio; Osone, Fumio; Hara, Akira; Okubo, Toshiyuki

doi:10.1016/j.bpsc.2016.11.006

Cited by 52 publications

(52 citation statements)

References 60 publications

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“…It is well-known that stress-induced neural alterations likely depends on specific characteristics of the brain regions such as hippocampus (Heim et al, 2008). In a MRS study with major depressive disorder patients, blood cortisol showed significant negative correlation with myo-inositol levels and dehydroepiandrosterone-sulfate (DHEAS) displayed a significant negative relation with glutamate levels in right hippocampus, but not mPFC (Shirayama et al, 2017). Unlike the cortisol response, which decreased after repeated exposure to the stressor, the DHEAS response concentrations increase in response to both acute and chronic (repeated) stress in a primate study (Maninger et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Anatomical and Neurochemical Correlates of Parental Verbal Abuse: A Combined MRS—Diffusion MRI Study

Kim

Yoo

Park

et al. 2019

Front. Hum. Neurosci.

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Despite the critical impact of parental dialog on children who remain physically and psychologically dependent, most studies have focused on brain alterations in people exposed to moderate-to-high levels of emotional maltreatment with/without psychopathology. We measured metabolites in the pregenual anterior cingulate cortex (pgACC) acquired with single-voxel proton magnetic resonance spectroscopy and anatomical connectivity assessed with probabilistic tractography in 46 healthy young adults who experienced no-to-low level parental verbal abuse (paVA) during their childhood and adolescence. The partial least square regression (PLSR) model showed that individual variance of perceived paVA was associated with chemical properties and structural connectivity of pregenual anterior cingulate cortex (pgACC; prediction R2 = 0.23). The jackknife test was used to identify features that significantly contributed to the partial least square regression (PLSR) model; a negative association of paVA was found with myo-inositol concentration, anatomical connectivities with the right caudate and with the right transverse temporal gyrus. Of note, positive associations were also found with the left pars triangularis, left cuneus, right inferior temporal cortex, right entorhinal cortex and right amygdala. Our results showing both a negative association of frontal glial function and positive associations of anatomical connectivities in several networks associated with threat detection or visual information processing suggest both anatomical and neurochemical adaptive changes in medial frontolimbic networks to low-level paVA experiences.

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Section: Discussionmentioning

confidence: 99%

Anatomical and Neurochemical Correlates of Parental Verbal Abuse: A Combined MRS—Diffusion MRI Study

Kim

Yoo

Park

et al. 2019

Front. Hum. Neurosci.

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“…Some evidence suggests that the mIns level in the brain is associated with changes in mood state [ 83 ]. Administration of mIns has been found to be therapeutic for obsessive–compulsive and panic disorders [ 83 , 84 ], depression [ 84 , 85 ], bipolar disorders, and concomitant sleep symptoms [ 100 , 101 ].…”

Section: Magnetic Resonance Spectroscopymentioning

confidence: 99%

Current Methods of Magnetic Resonance for Noninvasive Assessment of Molecular Aspects of Pathoetiology in Multiple Sclerosis

Hnilicová

Štrbák

Kolísek

et al. 2020

IJMS

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Multiple sclerosis (MS) is an autoimmune disease with expanding axonal and neuronal degeneration in the central nervous system leading to motoric dysfunctions, psychical disability, and cognitive impairment during MS progression. The exact cascade of pathological processes (inflammation, demyelination, excitotoxicity, diffuse neuro-axonal degeneration, oxidative and metabolic stress, etc.) causing MS onset is still not fully understood, although several accompanying biomarkers are particularly suitable for the detection of early subclinical changes. Magnetic resonance (MR) methods are generally considered to be the most sensitive diagnostic tools. Their advantages include their noninvasive nature and their ability to image tissue in vivo. In particular, MR spectroscopy (proton 1H and phosphorus 31P MRS) is a powerful analytical tool for the detection and analysis of biomedically relevant metabolites, amino acids, and bioelements, and thus for providing information about neuro-axonal degradation, demyelination, reactive gliosis, mitochondrial and neurotransmitter failure, cellular energetic and membrane alternation, and the imbalance of magnesium homeostasis in specific tissues. Furthermore, the MR relaxometry-based detection of accumulated biogenic iron in the brain tissue is useful in disease evaluation. The early description and understanding of the developing pathological process might be critical for establishing clinically effective MS-modifying therapies.

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“…Various regions of the brain are involved in executive memory. The medial temporal lobe (hippocampal system), prefrontal cortex, diencephalon (papillary body and thalamus), and amygdala are reciprocally connected and associated with learning and memory ( Naya et al, 2017 ; Shirayama et al, 2017 ; Guo et al, 2019 ). Short-term memory (including working memory) and long-term memory are separate systems.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effect of Optogenetics Varies With Distance From Channelrhodopsin-2 Expression in an Amyloid-β-Injected Mouse Model of Alzheimer’s Disease

Cui

Zhang

et al. 2020

Front. Neurosci.

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Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is the most common cause of dementia. Optogenetics uses a combination of genetic engineering and light to activate or inhibit specific neurons in the brain. Objective: The objective of the study was to examine the effect of activation of glutamatergic neurons in the hippocampus of mice injected with Aβ1-42 on memory function and biomarkers of neuroinflammation and neuroprotection in the brain to elucidate the clinical utility of optogenetic neuromodulation in AD. Methods: AAV5–CaMKII–channelrhodopsin-2 (CHR2)–mCherry (Aβ-CHR2 mice) or AAV5—CaMKII–mCherry (Aβ-non-CHR2 mice) was injected into the dentate gyrus (DG) of the bilateral hippocampus of an Aβ1-42-injected mouse model of AD. The novel object recognition test was used to investigate working memory (M1), short-term memory (M2), and long-term memory (M3) after Aβ1-42 injection. Hippocampus tissues were collected for immunohistochemical analysis. Results: Compared to controls, M1 and M2 were significantly higher in Aβ-CHR2 mice, but there was no significant difference in M3; NeuN and synapsin expression were significantly increased in the DG of Aβ-CHR2 mice, but not in CA1, CA3, the subventricular zone (SVZ), or the entorhinal cortex (ENT); GluR2 and IL-10 expressions were significantly increased, and GFAP expression was significantly decreased, in CA1, CA3, the DG, and the SVZ of Aβ-CHR2 mice, but not in the ENT. Conclusion: Activation of glutamatergic neurons by optogenetics in the bilateral DG of an Aβ-injected mouse model of AD improved M1 and M2, but not M3. A single-target optogenetics strategy has spatial limitations; therefore, a multiple targeted optogenetics approach to AD therapy should be explored.

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Myo-inositol, Glutamate, and Glutamine in the Prefrontal Cortex, Hippocampus, and Amygdala in Major Depression

Cited by 52 publications

References 60 publications

Anatomical and Neurochemical Correlates of Parental Verbal Abuse: A Combined MRS—Diffusion MRI Study

Anatomical and Neurochemical Correlates of Parental Verbal Abuse: A Combined MRS—Diffusion MRI Study

Current Methods of Magnetic Resonance for Noninvasive Assessment of Molecular Aspects of Pathoetiology in Multiple Sclerosis

Neuroprotective Effect of Optogenetics Varies With Distance From Channelrhodopsin-2 Expression in an Amyloid-β-Injected Mouse Model of Alzheimer’s Disease

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