Mykotische Keratitis: Klinische Zeichen, Diagnose, Therapie

Roth, Mathias; Steindor, Friedrich A; Kurzai, Oliver; Behrens–Baumann, W.; MacKenzie, Colin R.; Geerling, Gerd

doi:10.1055/a-0646-6404

Cited by 4 publications

(5 citation statements)

References 56 publications

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“…Alternatively, chronic-course fungal infection with lack of improvement may prove treatable by one of the above-named novel antimycotics obtained directly from the manufacturer. Before taking this step, however, antiseptics should also be tried [48,49] e.g. chlorhexidine [50,51] or polyhexamethylene biguanide with systemic terbinafine [3].…”

Section: Discussion and Prospectsmentioning

confidence: 99%

“…Alternativ besteht bei chronischem Verlauf und fehlender Besserung der Pilzinfektion die Möglichkeit, eines der o. g. neuen Antimykotika über den Hersteller zu beziehen. Vorher sollten aber noch Antiseptika versucht werden[48,49], z. B. Chlorhexidin[50,51] und Polyhexamethylen-Biguanid mit systemischem Terbinafin[3].InteressenkonfliktDer Autor gibt an, dass kein Interessenkonflikt besteht.Literatur [1] Ahmed SA, Hofmüller W, Seibold M et al Tintelnotia, a new genus in Phaeosphaeriaceae harbouring agents of cornea and nail infections in humans.…”

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New Antimycotics in the Pipeline – For Ophthalmology Too?

Behrens–Baumann

2021

Klin Monbl Augenheilkd

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Seven new antimycotics are presented that are at different points of development or approval. These substances are mainly first-in-class drugs. They are primarily developed for systemic administration. However, with the support of a pharmacist, the intravenous formulation may be used as eyedrops. In this short review, the activities of the substances against various fungal infections are described. After unsuccessful conventional therapy of fungal eye infections, one of these new substances might be suitable to cure the mycosis.

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Section: Discussion and Prospectsmentioning

confidence: 99%

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New Antimycotics in the Pipeline – For Ophthalmology Too?

Behrens–Baumann

2021

Klin Monbl Augenheilkd

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“…For this reason, the respective groups investigated (CL and FIL or NCL and YEA) overlapped in a large number of the parameters investigated. Because of the higher probability of an infection by filamentous pathogens in CL users, the broadest possible therapy should be initiated even if the pathogen is not yet identified (proposal for the therapy scheme, see ref. 20).…”

Section: Discussionmentioning

confidence: 99%

“…Because of the higher probability of an infection by filamentous pathogens in CL users, the broadest possible therapy should be initiated even if the pathogen is not yet identified (proposal for the therapy scheme, see ref. 20).…”

Section: Discussionmentioning

confidence: 99%

“…The current status of the literature on the therapy for keratomycosis and a proposal for a standardized procedure was recently published. 20 However, there is still no international gold standard. Accordingly, the German FK registery and other international studies show a high variance in the antimycotics used in different combinations, dosages, and administration methods.…”

Section: Discussionmentioning

confidence: 99%

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Results From the German Fungal Keratitis Registry: Significant Differences Between Cases With and Without a History of Contact Lens Use

Roth¹,

Holtmann²,

Daas³

et al. 2021

Cornea

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Purpose: Fungal keratitis (FK) is a serious ophthalmic disease with a potentially devastating outcome that seems to be increasing in recent years. The use of contact lenses (CLs) was evaluated as a risk factor for FK to determine possible differences in course and outcome.Methods: Data from 173 cases reported in the German FK registry until August 2019 were evaluated regarding CL behavior, other ophthalmological and general risk factors, age, sex, identified pathogens, conservative and surgical therapy, visual acuity, and findings at admission and follow-up.Results: One hundred seventy-four eyes from 173 patients between 2000 and 2019 were included [64.4% women, median age 54 (39; 72) years]; 49.7% wore CL, of which 81.3% were soft CL, and 50.3% had no history of contact lens use (NCL). CL users were significantly more often women and otherwise healthy (CL: 80.2% vs. NCL: 48.9%; P , 0.0001). The spectrum of pathogens among CL users showed a significantly higher proportion of infections with filamentous pathogens, in particular Fusarium sp.

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Mykotische Keratitis: Diagnose und Therapie

Roth,

Geerling

2023

Springer Reference Medizin

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Mykotische Keratitis: Klinische Zeichen, Diagnose, Therapie

Cited by 4 publications

References 56 publications

New Antimycotics in the Pipeline – For Ophthalmology Too?

New Antimycotics in the Pipeline – For Ophthalmology Too?

Results From the German Fungal Keratitis Registry: Significant Differences Between Cases With and Without a History of Contact Lens Use

Mykotische Keratitis: Diagnose und Therapie

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