Myelostimulating Activity of Pyperidine Compounds Biv-68, Biv-69, Biv-70, Biv-71

Baktybayeva, L. K.; Tauassarova, M. K.; Berlin, Kenneth Darrell; Yu, V.K.; Zazybin, A.G.; Malmakova, A.E.

doi:10.26577/eje-2018-1-799

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“…Double cytological control was used on blood smears. Blood smears were colored by the Giemsa method and counted under a SA3300S microscope under immersion (magnification 7 x 100), 100 cells for each smear sample, then the relative number of cells of each type was converted to an absolute value [24].…”

Section: Test Compoundsmentioning

confidence: 99%

Biological activity of 4-ethynyl-, 4-oxy-, 4-butoxypropylpyperidine and azaheterocyclic compounds

Daulet

Baktybayeva

Sokolenko

et al. 2021

ijbch

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The immune system of humans and higher animals performs an important function of maintaining the constancy of the internal environment of the body by detecting and eliminating foreign substances of an antigenic nature, both endogenously created and exogenously penetrating. This function of the immune system is performed by factors of innate and acquired immunity. As the name suggests, immunostimulants are the agents boosting the immune response. The new chemical series of compounds is promising for the search new effective immunostimulating drugs. Acute toxicity and the effect on peripheral blood hemogram parameters and on the subpopulation composition of lymphocytes were determined in the compounds (piperidine-containing derivatives):ethoxyethyl)-4-ethynyl-4hydroxypiperidine) dihydrochloride and, 1:1 complexes of β-cyclodextrin with 1-(2-ethoxyethyl)-4-(2-ethoxyethoxyl)-4-ethynylpiperidine, 1-(2-ethoxyethyl)-4-(2-methoxyethoxyl)-4-ethynylpiperidine, 7-(2-methoxyethyl)-2,2-dimethyl-3-thia-7-azabicyclo[3.3.1]nonane or 3-(2-morpholinoethyl)-7-(3isopropoxypropyl) diazabicyclo[3.3.1] nonane with β-cyclodextrin. Compound ˗ 1-(3-n-butoxypropyl) piperidine-3-methyl-4-spiro-5'-imidazolidine-2',4'-dione, exceeds the immunostimulating activity of the comparison drug of levamizole by 3.1 times and shows low toxicity.

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Section: Test Compoundsmentioning

confidence: 99%