Myeloproliferative Neoplasms: Chronic Myelogenous Leukemia, Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis

Tibes, Raoul; Khera, Gurcharan Singh; Mesa, Ruben A.

doi:10.1002/9781118464557.ch47

Textbook of Uncommon Cancer 2012

DOI: 10.1002/9781118464557.ch47

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Myeloproliferative Neoplasms: Chronic Myelogenous Leukemia, Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis

Raoul Tibes

Gurcharan Singh Khera

Ruben A. Mesa

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2013

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Emerging drugs for polycythemia vera

Tibes

Mesa

2013

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Therapeutic goals in PV are to prevent vascular events, reduce symptoms and for future therapies delay/prevent disease progression. Currently available treatments such as phlebotomy, antiplatelet therapy, managing risk factors and cytoreductive therapies such as hydroxyurea (HU) and PEG-INFa2a are effective. JAK2 inhibitors recently have shown promising activity in reducing PV symptoms and spleen size and improving blood counts. Yet the influence of long-term outcome and delaying disease progression is unknown. Thus, there still remains an unmet medical need for improved therapy and symptom management in PV.

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Emerging drugs for polycythemia vera

Tibes

Mesa

2013

Expert Opinion on Emerging Drugs

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Myeloproliferative Neoplasms: Chronic Myelogenous Leukemia, Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis

Cited by 1 publication

References 124 publications

Emerging drugs for polycythemia vera

Emerging drugs for polycythemia vera

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